共查询到20条相似文献,搜索用时 15 毫秒
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Selective neurone death as a possible memory mechanism 总被引:1,自引:0,他引:1
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Ozone as a possible radiomimetic gas 总被引:1,自引:0,他引:1
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Receptive fields of sensory cortical neurons are plastic, changing in response to alterations of neural activity or sensory experience. In this way, cortical representations of the sensory environment can incorporate new information about the world, depending on the relevance or value of particular stimuli. Neuromodulation is required for cortical plasticity, but it is uncertain how subcortical neuromodulatory systems, such as the cholinergic nucleus basalis, interact with and refine cortical circuits. Here we determine the dynamics of synaptic receptive field plasticity in the adult primary auditory cortex (also known as AI) using in vivo whole-cell recording. Pairing sensory stimulation with nucleus basalis activation shifted the preferred stimuli of cortical neurons by inducing a rapid reduction of synaptic inhibition within seconds, which was followed by a large increase in excitation, both specific to the paired stimulus. Although nucleus basalis was stimulated only for a few minutes, reorganization of synaptic tuning curves progressed for hours thereafter: inhibition slowly increased in an activity-dependent manner to rebalance the persistent enhancement of excitation, leading to a retuned receptive field with new preference for the paired stimulus. This restricted period of disinhibition may be a fundamental mechanism for receptive field plasticity, and could serve as a memory trace for stimuli or episodes that have acquired new behavioural significance. 相似文献
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Thalidomide as a possible biological acylating agent 总被引:1,自引:0,他引:1
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T-mycoplasmas as a possible cause for reproductive failure 总被引:7,自引:0,他引:7
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In this paper we consider a specific model of membrane systems, i. e. membrane systems with attributes. In these systems, the information is placed at the membranes in form of attributes, no objects are considered inside the membranes except for other membranes. The membrane system with attributes evolves according to rules that compute new values for the attributes from the attributes assigned to the membranes involved in the rule. The model of membrane systems with attributes allows us to specify business transactions in a precise way and to simulate different models for such transactions with a suitable tool for membrane systems with attributes. 相似文献
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In this paper we consider a specific model of membrane systems, i. e. membrane systems with attributes. In these systems, the information is placed at the membranes in form of attributes, no objects are considered inside the membranes except for other membranes. The membrane system with attributes evolves according to rules that compute new values for the attributes from the attributes assigned to the membranes involved in the rule. The model of membrane systems with attributes allows us to specify business transactions in a precise way and to simulate different models for such transactions with a suitable tool for membrane systems with attributes. 相似文献
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Alkaloids as possible intermediaries in plant metabolism 总被引:1,自引:0,他引:1
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Causal links between the rise of a large mountain range and climate have often been considered to work in one direction, with significant uplift provoking climate change. Here we propose a mechanism by which Cenozoic climate change could have caused the rise of the Andes. Based on considerations of the force balance in the South American lithosphere, we suggest that the height of, and tectonics in, the Andes are strongly controlled both by shear stresses along the plate interface in the subduction zone and by buoyancy stress contrasts between the trench and highlands, and shear stresses in the subduction zone depend on the amount of subducted sediments. We propose that the dynamics of subduction and mountain-building in this region are controlled by the processes of erosion and sediment deposition, and ultimately climate. In central South America, climate-controlled sediment starvation would then cause high shear stress, focusing the plate boundary stresses that support the high Andes. 相似文献
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Immunoglobulin G as possible precursor of chemotactic factor 总被引:3,自引:0,他引:3