A new compound effective against acute fascioliasis in sheep

Zusammenfassung 2-Acetoxy-4-chlor-3,5-dijodbenzanilid zeigte eine hohe Wirksamkeit gegen junge und gereifteF. hepatica andH. controtus in Schaften bei einer oralen Dosis von 25 und 40 mg/kg. Die gute Verträglichkeit der Verbindung in Schafen ergab sich aus Feldversuchen in Australien.     

A new type of non-kaliuretic diuretic compound

Zusammenfassung Die Synthese von 1-(Pyrrolidino)-3,5-diphenyl-4-(-pyridyl)-cyclohexan, Su-15049, und dessen wasserlöslichen Citrats werden beschrieben. Diese Verbindungen besitzen starke diuretische und natriuretische Eigenschaften; sie sind aber nicht kaliuretisch wirksam.     

A new drug against Paragonimus infection

Summary An oral dose of 50–100 mg/kg b.wt of a new anthelmintic, albendozole, for 2–3 weeks killed adult flukes and stopped shedding of ova of Paragonimus kellicotti in experimentally infected cats. No clinical signs related to treatment were recognized. This low toxicity of albendozole may be useful in treating human paragonimiasis.     

Anthelmintic activity of a benzimidazoline compound in sheep by abomasal infusion

Summary In vitro and in vivo data on the benzimidazoline compound indicate anthelmintic potential when introduced directly into the abomasum.     

Anthelmintic activity of a benzimidazoline compound in sheep by abomasal infusion

In vitro and in vivo data on the benzimidazoline compound indicate anthelmintic potential when introduced directly into the abomasum.     

Reduction of acute toxicity of cyclophosphamide and X-rays by the new immunomodulating compound BM 12.531

Summary BM 12.531, the 2-[2-cyanaziridinyl-(1)]-2-[2-carbamoylaziridinyl-(1)]-propane, (prop. INN Azimexon), reduces significantly the acute toxicity of cyclophosphamide and X-rays in rats and mice, respectively. The leucopenia induced by X-rays was partially compensated by BM 12.531 in rats.This work was supported by Schutzkommission beim Bundesministerium des Innern.     

A new quaternary ammonium compound with plant growth regulatory activity

Summary Of several quaternary ammonium derivatives tested, 1-allyl-1-(3,7-dimethyloctyl)piperidinium bromide showed the best growth-retarding activity. OnChrysanthemum morifolium the growth retardation obtained with a single application of 100–200 ppm compared favourably with that obtained from 2–3 applications of 3400 ppm of N-dimethylaminosuccinamic acid (daminozide).     

Reduction of acute toxicity of cyclophosphamide and X-rays by the new immunomodulating compound BM 12.531.

BM 12.531, the 2-[2-cyanaziridinyl-(1)]-2-[2-carbamoylaziridinyl-(1)]-propane, (prop. INN Azimexon), reduces significantly the acute toxicity of cyclophosphamide and X-rays in rats and mice, respectively. The leucopenia induced by X-rays was partially compensated by BM 12.531 in rats.     

Chemotaxis of human neutrophils against gravity: A new method

Summary A new method is described in which human neutrophils were made to migrate upward and against gravity. Thus, the possible effect of gravity on cell migration and consequent detachment of cell after migration have been eliminated.Supported in part by N.I.H. grants: No.HL19628-03, No. DE04898, No. CA24215 and No.RR05493).     

Arylpyridyl-thiosemicarbazones: A new class of anti-juvenile hormones active against Lepidoptera

Summary A new class of anti-juvenile hormone agents is described. Active anti-juvenile hormone compounds were either diazine thiosemicarbazones or aryl substituted pyridyl thiosemicarbazones, synthesized from substituted benzaldehydes. While many analogs in these classes showed feeding and growth inhibition in a variety of insects, a select group caused formation of precocious pupal characteristics inAgrotis ipsilon (black cutworm) andHeliothis virescens (tobacco budworm) and black cuticle and precocious pupae inManduca sexta (tobacco hornworm). They were active only by diet incorporation. The symptoms of precocious development could be reversed by co-administration of a juvenoid. One of the active compounds was shown to inhibit juvenile hormone biosynthesis in vitro by corpora allata of the cockroachDiploptera punctata. However, none of the compounds were active inhibitors of purified chicken liver prenyl transferase.     

5-Azacytidine,a new,highly effective cancerostatic

Zusammenfassung Die hohe bakteriostatische und cancerostatische Wirkung eines neuen Antimetaboliten, 5-Azacytidin, wird beschrieben.     

Some new aspects of a sheep pineal gonadotropic inhibiting activity in in vitro experiments

Résumé Par des méthodes simples et bien déterminées: gelfiltration sur Sephadex G-25, G-10 et l'ultrafiltration par des diaflomembranes UM-02 et UM-05, on a pu isoler à partir d'un extrait aqueux d'épiphyses de mouton, des fractions capables d'inhiber l'activité gonadotrope hypophysaire. Cette activité inhibitrice a pu être localisée par l'électrophorèse sur papier. Les fractions ainsi obtenues sont capables d'inhiber in vitro l'excrétion hypophysaire de FSH et de LH.

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Acknowledgment. The authors gratefully acknowledge Dr. Reichert and Dr. Niswender for the generous supply of antigens and antibodies for the radioimmunoassay. Our thanks are also due to Mrs. A. E. M. Horwitz-Bresser for her skilful assistance in the isolation procedures.     

Dexamethasone protection against the acute lethality of ethanol in mice

Summary The administration of dexamethasone (DXM, 2.00 mg/kg) 1 h prior to the injection of lethal doses of ethanol was found to offer complete protection against ethanol toxicity at doses up to 5.25 g/kg and partial protection using higher doses. It is suggested that DXM central action might be involved in the protection against ethanol toxicity.Supported by a grant from U.S. National Aeronautics and Space Administration.     

A new group of rifamycin derivatives displaying activity against rifampicin-resistant mutants ofStaphylococcus aureus

Zusammenfassung Unter einer grossen Anzahl semi-synthetischer Rifamycinderivate wurde eine Gruppe strukturell verwandter Verbindungen gefunden, die neben ihrer hohen Wirksamkeit (MIC 0,002-0,01 g/ml) gegenüber rifampicinsensiblen, grampositiven Keimen in vitro auch eine gute Wirkung (MIC 1–10 (g/ml) gegenüber rifampicinresistenten, grampositiven Keimen aufweisen. Die Resistenzrate grampositiver rifampicinresistenter und -sensibler Keime ist bezüglich dieser Verbindungen mindestens 100mal kleiner als bei Rifampicin. Die Wirkung gegenüber resistenten Keimen scheint nicht auf einer Beeinflussung der DNA-abhängigen RNA-Polymerase zu beruhen. Eine Struktur-Wirkungs-Beziehung wird angegeben.