Acute effects of tolamolol on renal function in hypertensive patients

The renal haemodynamic effects of a single i.v. administration of tolamolol were studied in 9 hypertensive subjects. No change of GFR and ERPF was observed after tolamolol, while urine output decreased and urine creatinine concentration increased. A reduction of the heart rate was confirmed. Blood pressure was unchanged.     

Der Einfluss des Urin-pH auf die Aktivität von Urinenzymen

Summary The relationship between the pH of urine and the measured activity of ULDH, UAP and UAA was investigated in vivo and in vitro. The activity of ULDH and UAP is only half as much, or less, in acid urine (pH 4.8–5.1) as it is in alkaline urine (pH 7.0–8.1). The UAA activity, however, does not change in the pH range measured. The isoenzymes ULDH 2–4, present in alkaline urine of normal adults, does not appear in acid urine.     

Fucosidosis and blood group substances in the urine]

Glycopeptide and oligosaccharide fractions obtained from fucosidosis urine contains more Lea activity (4-8 fold) than control urine. Both fucosidosis fractions also contained Leb and H activities, no A activity in contrast to the salivary and erythrocyte phenotypes (A, Le a+ b-). The amount of Leb activity is lower in both fractions (1) and (2) than that of Leb control children (4-16 fold decrease). Blood group A activity was not detected at any concentration used (less than or equal to 50 fold-concentrated urine) whereas A activity was found in (A, Le a- b+) control urine. On the contrary, both fucosidosis fractions contained H activity, whereas A (Le a- b+) control children fractions had none (less than or equal to 50-fold concentrated urine). H and Leb activity might originate from Lea precursor apart from the "non-secretory" type of the patient.     

Wirkung der Adrenalektomie und Desoxycorticosteronbehandlung auf die Ascorbinämie und Ascorbinurie der Katze

Summary Two cats were adrenalectomized and kept healthy with daily injections of desoxycorticosterone acetate. The ascorbic acid concentration of blood and urine remained the same as in normal controls. When Dexoxy-corticosterone was omitted, a crisis ensued but the blood and urine concentration of ascorbic acid did not decrease.     

Metabolism of 1,3,7-trimethyldihydrouric acid in the rat: New metabolic pathway of caffeine

Summary [1-CH₃-¹⁴C] 1,3,7-trimethyldihydrouric acid which, in quantity, is the most important caffeine metabolite, was isolated and purified from the urine of rats fed with [1-CH₃-¹⁴C] caffeine. The oral administration of this metabolite to rats showed that 1,3,7-trimethyldihydrouric acid was excreted unchanged in urine and was therefore an end product of caffeine metabolism. This result implies a new metabolic pathway of caffeine.     

Use of three specific radioimmunoassays in measuring neurohypophysial hormone content and plasma concentrations of vasopressin, oxytocin and DDAVP in rats after prolonged infusion of DDAVP

Specific radioimmunoassays (RIA) were employed for measuring plasma and neurohypophysial concentrations of oxytocin (OT) and vasopressin (AVP) after administration of 1-deamino-8-D-Arg-vasopressin (DDAVP). DDAVP concentrations were measured by a newly-developed specific RIA. Through the use of minipumps, DDAVP was infused i.p. over a period of 3 days in normally hydrated rats. Despite decreased urine production and increased urine osmolality no changes could be observed in neurohypophysial and plasma hormone concentrations.     

Use of three specific radioimmunoassays in measuring neurohypophysial hormone content and plasma concentrations of vasopressin,oxytocin and DDAVP in rats after prolonged infusion of DDAVP

Summary Specific radioimmunoassays (RIA) were employed for measuring plasma and neurohypophysial concentrations of oxytocin (OT) and vasopressin (AVP) after administration of 1-deamino-8-D-Arg-vasopressin (DDAVP). DDAVP concentrations were measured by a newly-developed specific RIA. Through the use of minipumps, DDAVP was infused i.p. over a period of 3 days in normally hydrated rats. Despite decreased urine production and increased urine osmolality no changes could be observed in neurohypophysial and plasma hormone concentrations.     

Chemistry of male dominance in the house mouse, Mus domesticus

Two terpenic constituents, E,E,-alpha-farnesene and E-beta-farnesene, were found to be elevated in dominant male urine when compared to subordinate or control males. These two urinary compounds were absent in the bladder urine of males; however, they were the most prominent constituents of the perputial gland's aliquots. The results of a two-choice preference test, conducted on ICR/Alb subordinate males, gave a strong indication that these two terpenic constituents introduced into the previously attractive stimulus significantly discouraged prolonged investigations by male mice. The compounds, whether present in the urine matrix or water, rendered the stimulus with a quality behaviorally similar to the urine of dominant males. It appears that they may be synonymous with the previously described aversion signal produced by dominant males. We suggest that these compounds may play a wide-ranging role in the territorial marking behavior of male mice.     

Odorous urine following asparagus ingestion in man

The production of odorous urine after the ingestion of asparagus has been shown to occur in 43% of 800 volunteers investigated. This characteristic is reproducible over a 12-month-period and has been shown to remain with individuals for virtually a lifetime. Family studies suggest that the ability to produce the odorous urine is inherited as an autosomal dominant trait.     

Ureteral contractions induced by rat urine in vitro: Probable involvement of renal kallikrein

Summary Rat urine, even at a 110 final dilution in Tyrode's solution, stimulates contraction of the ureteral musculature in vitro. This effect can be ascribed to the presence of kallikrein or a kallikrein-like enzyme in urine. Isometric contractions of ureters were prevented by previous addition of aprotinin to the organ bath. Urine also lost its activity after inactivation of enzymes by heat or acid treatment.Acknowledgments. Aprotinin (Trasylol^®) was kindly supplied by Baypropharm, Köln, W.-Germany. This work was supported by the German Research Foundation (SFB 90).     

Effect and fate of intravenously administered porphobilin in rats

Summary It rats after i.v. prophobilin, blood pressure and pulse rate remained stable, the animals were calm and moved freely with no symptoms or signs of nervous effect. Prophobilin was rapidly excreted in the urine.     

Odorous urine following asparagus ingestion in man

Summary The production of odorous urine after the ingestion of asparagus has been shown to occur in 43% of 800 volunteers investigated. This characteristics is reproducible over a 12-month-period and has been shown to remain with individuals for virtually a lifetime. Family studies suggest that the ability to produce the odorous urine is inherited as an autosomal dominant trait.     

Identification of a testosterone-dependent unique volatile constituent of male mouse urine: 7-exo-ethyl-5-methyl-6,8-dioxabicyclo[3.2.1]-3-octene

Investigations regarding the chemical composition of the volatiles in male mouse urine have recently enabled the structural elucidation of a hitherto unreported urinary component, 7-exo-ethyl-5-methyl-6,8-dioxabicyclo[3.2.1]-3-octene. This compound's uniqueness to mouse urine and its dependence on testosterone levels in the male suggest its probable role as a mouse pheromone or pheromone adjuvant.     

Zur Trennung der C19-Steroide des Harns im Dünnschichtchromatogramm

Summary By a change of method to thin-layer chromatography, it was possible to fractionate completely the 17-ketosteroids from urine extract in one run. The chromatography was done in a horizontal manner on plates of 200×550 mm.     

Die durch animalische Mucoproteine verursachte Wachstumshemmung

Summary Anti-growth activity of animal mucoproteins on germinating seeds ofLupinus albus was tested; the inhibition with plasma mucoprotein was statistically significant. The inhibition with urine mucoprotein according toAnderson was the most effective.     

The renal concentrating ability of newly born Brattleboro rats (hereditary diabetes insipidus).

In Brattleboro rats, there was no difference in urine osmolality between animals with and without diabetes insipidus after water deprivation up to age 14 days, and it appeared at age 18 days due to increase of osmolality in non-diabetic individuals.     

The renal concentrating ability of newly born brattleboro rats (hereditary diabetes insipidus)

Summary In Brattleboro rats, there was no difference in urine osmolality between animals with and without diabetes insipidus after water deprivation up to age 14 days, and it appeared at age 18 days due to increase of osmolality in non-diabetic individuals.     

Volatile constituents of wolf (Canis lupus) urine as related to gender and season

Summary The volatile constituents of wolf urine were examined via capillary gas chromatography and compared among male, female, and castrate male. Several compounds including methyl isopentyl sulfide, 3,5-dimethyl-2-octanone, and acetophenone were clearly associated with the gender of the animal and many displayed a seasonal dependence. In addition, 2 long-chain aldehydes isolated from urine samples by an HPLC procedure also correlated with the endocrine status of the animal.This work was partially funded by the US Fish and Wildlife Service.We thank Dr Sharon L. Smith of IBM Instruments, Danbury, Connecticut, for recording spectra of some wolf urinary constitutents on an IBM Fourier-transform IR spectrometer.No such compounds were observed in any other animal species during our previous work with several mammals.     

Formation of indolyl-3-acetylaspartic acid in rats

Summary Indolyl-3-acetylaspartic acid (IAAsp) was detected in the urine of rats given indolyl-3-acetic acid (IAA) i.p. It was ascertained that the conversion of IAA into IAAsp could be carried out not only in plants but also in animals.