Effect of pylorus ligation on gastric mucosal mast cell population in normal and adrenalectomised albino rats.

Pylorus ligation in normal albino rats acts like a stressor leading to degranulation of mast cells in gastric mucosa, thereby decreasing their number. This decrease is less pronounced when pylorus ligation is done in adrenalectomized rats. This implies that action of a stressor on gastric function involves the adrenal steroids which liberate the powerful gastric stimulant histamine from gastric mucosal mast cells.     

Effect of bilateral adrenalectomy and parenteral betamethasone on gastric mucosal mast cell population in albino rats

Summary The histamine-laden mast cells gastric mucosa in albino rats are shown to degranulate on administration of Betamethasone, but they increase in number in adrenalectomized rats. It is concluded that Betamethasone, and also adrenal glucocorticoids incrase gastric secretion by liberating histamine from mast cells and histamine in turn acts on the gastric glands.     

Effect of bilateral adrenalectomy and parenteral betamethasone on gastric mucosal mast cell population in albino rats.

The histamine-laden mast cells of gastric mucosa in albino rats are shown to degranulate on administration of Betamethasone, but they increase in number in adrenalectomized rats. It is concluded that Betamethasone, and also adrenal glucocorticoids increase gastric secretion by liberating histamine from mast cells and histamine in turn acts on the gastric glands.     

Effect of subdiaphragmatic vagotomy on production of gastric ulcers in pylorus-ligated albino rats

Summary A reduction in volume and free and total acidity of gastric content was noted along with reduction in ulcer index, with a shift of the site of ulceration from fundus to the glandular part of stomach, following vagotomy in pylorus-ligated rats. Low volume and acidity explains the absence of ulcers in the fundus, but the increased involvement of glandular part in ulceration is possibly due to weakening of the mucosal barrier following vagotomy.     

Effect of subdiaphragmatic vagotomy on production of gastric ulcers in pylorus-ligated albino rats.

A reduction in volume and free and total acidity of gastric content was noted along with reduction in ulcer index, with a shift of the site of ulceration from fundus to the glandular part of the stomach, following vagotomy in pylorus-ligated rats. Low volume and acidity explains the absence of ulcers in the fundus, but the increased involvement of glandular part in ulceration is possibly due to weakening of the mucosal barrier following vagotomy.     

Effect of stimulation of vagus nerves on gastric tissue histamine concentration in albino rats

Summary 2 different time schedules were applied in order to stimulate vagus nerves around the oesophagus at the region of the cardio-oesophageal junction. The result shows a significant reduction in gastric tissue histamine concentration following vagal stimulation, the reduction being more when the duration of stimulation was longer.The authors are grateful to Dr V. Srinivasan, Director, Sarabhai Research Centre, Baroda, India, for donating the animals required for carrying out this work.     

Effect of stimulation of vagus nerves on gastric tissue histamine concentration in albino rats.

2 different time schedules were applied in order to stimulate vagus nerves around the oesophagus at the region of the cardio-oesophageal junction. The result shows a significant reduction in gastric tissue histamine concentration following vagal stimulation, the reduction being more when the duration of stimulation was longer.     

Effect of daily parenteral injection of betamethasone on histamine concentration of gastric tissue in albino rats

Summary Gastric tissue histamine concentration was determined in albino rats following daily parenteral injection of betamethasone over a period of 12 days. The result shows a highly significant fall in gastric tissue histamine concentration in comparison with that in saline-treated albino rats over a similar period.This investigation was carried out as a part of a project supported by a research grant from Medical Research Centre, Bombay Hospital Trust, Bombay, India.     

Effect of daily parenteral injection of betamethasone on histamine concentration of gastric tissue in albino rats

Gastric tissue histamine concentration was determined in albino rats following daily parenteral injection of betamethasone over a period of 12 days. The result shows a highly significant fall in gastric tissue histamine concentration in comparison with that in saline-treated albino rats over a similar period.     

Electron microscopy of gastric mucosal innervation in rats

Summary Electron microscopy of the rat stomach has shown vagal innervation of gastric epithelial cells with contact points. Unmyelinated axons of diameter 0.06 and 0.20 m were demonstrated passing in the connective tissue between epithelial cells.     

Effect of lindane on the skin of albino rats

Zusammenfassung Langfristig wiederholte Lindan-Applikation ruft bei der Abinoratte histopathologische hautveränderungen hervor: Hyperkeratinisation, intraepidermale und dermale Abszesse, Infiltration polymorphkerniger Zellen sowie Vakuolisation und Vielkernigkeit in der Malpighi-Schicht.

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Pury -isomer of 1,2,3,4,5,6-hexachlorocyclohexane.     

Inhibitory influence of ligation of the small intestine on gastric secretion in the pylorus-ligated rats

Résumé La ligature de l'intestin, particulièrement du duodénum, gêne la sécrétion gastrique chez le Rat à pylore lié avec ou sans fistule fine.     

A comparative study of the gastric ulcerogenic effects of stress and reserpine in rats with decreased stomach wall mast cell populations

Summary Stress-induced gastric glandular ulcers in rats appeared less severe than those evoked by reserpine, although glandular mucosal mast cell counts were equally decreased. Prior depletion of the glandular mucosal mast cell population confirmed the hypothesis that an additional mechanism contributes to reserpine ulceration.     

Effect of feeding psoralen on the copper content of different organs in albino rats

Zusammenfassung Psoralenfütterung von Ratten bewirkt eine Vermehrung des Kupfergehaltes in der Milz und eine Verminderung in der Leber. In der Haut sind die Werte nicht einheitlich.     

Quantitative cytophotometric analyses of mesenteric mast cell granulation in acute soman intoxicated rats

Effects of the organophosphate neurotoxin soman on rat mesenteric mast cell granule content were determined using scanning-integrating microdensitometric analysis of individual cell metachromasia. Mast cell degranulation was evidenced both with sublethal (0.5 LD50) and lethal (1.5 LD50) dosages and as early as 3-10 min post-injection. These data indicate a possible contribution of mast cell autacoids in the genesis of organophosphate-induced respiratory and circulatory collapse.