Neuromuscular blocking activity of dibekacin,a new semisynthetic aminoglycoside antibiotic

Summary Dibekacin possesses the untoward effect of producing a neuromuscular blockade. Neostigmine is unable to reverse the neuromuscular blockade produced by dibekacin. Calcium has not only the ability to restore the neuromuscular transmission but also to exert protective action against the neuromuscular blocking activity of dibekacin.     

Partricin methyl ester,a semisynthetic polyene antibiotic

Zusammenfassung Es wurde der Methylester von Partricin, eines polyenischen Antibiotikums, hergestellt. Das Produkt zeigte eine gesteigerte Aktivität gegen Hefen und eine verminderte Toxizität.     

Flambamycin,a new antibiotic fromStreptomyces hygroscopicus DS 23 230

Résumé La flambamycine, nouvel antibiotique produit parStreptomyces hygroscopicus DS 23 230, est un hétéroside dont l'aglycone est l'acide dichloroisoéverninique, précédemment mis en évidence dans l'avilamycine, la curamycine et l'éverninomycine. Tant in vitro qu'in vivo elle inhibe fortement la croissance des cocci gram-positifs ou-négatifs, mais thérapeutiquement elle n'est utilisable que par la voie parentérale.     

Transfer of R-factor mediated aminoglycoside antibiotic resistance in the allantoic cavity of chick embryos

Zusammenfassung Die Allantoishöhle von 8 Tage alten Hühnerembryonen erwies sich als geeignet für die in vivo-Übertragung der Aminoglykosid-Antibiotika-Resistenz der klinisch isolierten StämmeE. coli 1531 undK. pneumoniae 829 auf den RezipientenE. coli K-12, Stamm 1485.     

Thermozymocidin new antifungal antibiotic from a thermophilic eumycete

Riassunto È stato isolato un nuovo antibiotico, denominato termozimocidina, attivo contro lieviti e funghi filamentosi, prodotto in coltura sommersa da un eumicete termofilo. Vengono presentate le principali propietà chimiche, fisiche e biologiche che ne permettono la sua caratterizzazione.     

Emericid,a new polyether antibiotic fromStreptomyces hygroscopicus (DS 24 367)

Summary Emericid is a new polyether polycyclic ionophore antibiotic excreted byStreptomyces hygroscopicus (DS 24 367). Active in vitro against Gram-positive bacteria, it is ineffective in vivo. At a 0.006–0.02% level in the diet it protects chickens and rabbits against coccidiosis.From a recent paper byN. Otake (Tetrahedron Lett.1970, 4147) emericid and lonomycin would be identical.     

Emericid, a new polyether antibiotic from Streptomyces hygroscopicus (DS 24 367).

Emericid is a new polyether polycyclic ionophore antibiotic excreted by Streptomyces hygroscopicus (DS 24 367). Active in vitro against Gram-positive bacteria, it is ineffective in vivo. At a 0.006-0.02% level in the diet it protects chickens and rabbits against coccidiosis.