Peculiar response of Brattleboro rats to selenite

Summary Brattleboro rats were given, on the 10th day of life, a single high dose of sodium selenite. 90% of Brattleboro heterozygotes responded to the treatment by the formation of cataract whereas homozygotes with diabetes insipidus exhibited no cataract.     

Visceral localization of 14C gentamicin in the rat after administration of a single dose

When administered intravenously to Rats, 14C Gentamicin decreased very fast in all tissues, except in kidney and cartilage. Some flexures of the small intestine contained radioactive carbon, and that was evidence for the biliary elimination of a part of the aminoglycoside. In animals with water restriction, the distribution of the antibiotic in tissues was similar to the distribution in animals with free access to water.     

The short-term effects of a single dose of erythropoietin upon reticulocytes in starved rats

Zusammenfassung Nach einer Injektion von Erythropoietin in hungernde Ratten beobachteten wir eine Erhöhung der Reticulocyten. Junge Formen von Reticulocyten erschienen bereits 12 h nach der Behandlung. Dieser Befund deutet vielleicht darauf hin, dass Erythropoietin nicht nur die Stammzellen angreift.

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Supported by Grant No. CY-3071 from the U.S.P.H.S.     

Protection against mercuric chloride nephropathy by sodium selenite in the rat]

Daily intraperitoneal injection of 2.5 or 5 mumole HgCl2 to male Rats weighing 250 to 350 g induces an early intense increase of urine gamma-glutamyl transferase activity. In the same conditions, equimolecular administration of sodium selenite and mercuric chloride induces no increase of the enzymuria for the low dose: for the high dose- a minor and more persistent increase of urine GGT is observed. Thus, the activity of urines GGT allows, in vivo, to establish that sodium selenite protects Rat kidney against toxic effects of mercuric chloride.     

An escape phenomenon from water and sodium retention induced by propranolol in rats

Rats given a daily dose of propranolol 45 mg/kg b.wt retain water and sodium for 4 days, escaping during the 5th and 6th days in which their excretions are larger than basal values. Afterwards, in the period studied, they make a new retention and clearing is less accentuated. No relationship could be found between these retentions and plasma renin activity or renal renin content.     

An escape phenomenon from water and sodium retention induced by propranolol in rats

Summary Rats given a daily dose of propranolol 45 mg/kg b.wt retain water and sodium for 4 days, escaping during the 5th and 6th days in which their excretions are larger than basal values. Afterwards, in the period studied, they make a new retention and clearing is less accentuated. No relationship could be found between these retentions and plasma renin activity or renal renin content.Acknowledgments. The authors thank Mrs Inmaculada Millás for excellent technical assistance and Maria Isabel Navajos for secretarial help.     

Neurotoxicity by the dividing administration of critical dose of phosvel

Phosvel, an organophosphorus insecticide, produces delayed neurotoxicity in hens. A change in the toxicity, and in the residue of insecticide in the fat, were observed when the critical dose which was demonstrated in the case of a single dose was subdivided.     

Neurotoxicity by the dividing administration of critical dose of phosvel

Summary Phosvel, an organophosphorus insecticide, produces delayed neurotixicity in hens. A change in the toxicity, and in the residue of insecticide in the fat, were observed when the critical dose which was demonstrated in the case of a single dose was subdivided.     

Fibrosarcoma induced by administration of methyl cholanthrene into post extraction sockets of mandibular molars in rats

Summary Methyl cholanthrene in crystalline form and in a slow releasing vehicle was introduced into mandibular post extraction sockets. Fibrosarcomas developed within 9 months.     

Intrarenally induced infection in rats: Kidney infecting dose and sex dependence

Zusammenfassung LebendeE. coli-Bakterien wurden bei Ratten direkt in die Niere injiziert. Für die Infektion war eine bestimmte Mindest-Keimmenge erforderlich. Bei Injektion höherer Dosen (Chronizität) überstanden die männlichen Tiere die Infektion offenbar schneller und leichter als die weiblichen.     

Membrane constants and sodium conductance of a single muscle fibre

Riassunto Nella singola fibra muscolare di cavia a 38°C sono state determinate, applicando la «square pulse analysis», la resistenza, la costante di tempo, la costante di spazio e la capacità della membrana a riposo. È stato inoltre possibile calcolare la massima conduttanza per il sodio,gn a, che è risultata di 35,3 mmho/cm².