共查询到20条相似文献,搜索用时 15 毫秒
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Enhancing effect of antilymphocytic globulin on human leprosy infection in thymectomized mice 总被引:6,自引:0,他引:6
J M Gaugas 《Nature》1968,220(5173):1246-1248
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Prevention of rapid immune elimination of anti-lymphocytic globulin in transplant patients 总被引:4,自引:0,他引:4
W T Butler R D Rossen E M Hersh M E DeBakey E B Diethrich D K Brooks D A Cooley J J Nora R D Leachman D G Rochelle J J Trentin K P Judd A C Beall D E Jenkins R O Morgen V Knight 《Nature》1969,224(5222):856-860
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Properties of phenoloxidase in Mycobacterium leprae 总被引:2,自引:0,他引:2
K Prabhakaran 《Nature》1968,218(5145):973-974
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Features of antibody formation in neonatally thymectomized mice 总被引:2,自引:0,他引:2
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Cellular basis of the immunological defects in thymectomized mice 总被引:17,自引:0,他引:17
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Time-course studies on antibody response in thymectomized and sham-thymectomized mice 总被引:3,自引:0,他引:3
N R Sinclair 《Nature》1965,208(5015):1104-1105
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Neonatal thymectomy and non-viral mammary tumours in mice 总被引:3,自引:0,他引:3
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Cyclosporin A (CsA) acts as a powerful immunosuppressive agent, and also, when given in repeated doses, can cause T-cell-dependent graft-versus-host disease and organ-specific autoimmune disease in rodents. This suggests that CsA interferes with the processes governing self-tolerance, either by nullifying the activity of T suppressor cells or by preventing the deletion of autoreactive T cells during ontogeny in the thymus. We report here that irradiated mice given repeated injections of CsA show striking dysfunction of the thymus. There are two different effects, the first of which is that CsA seems to block the differentiation of immature CD4+CD8+ thymocytes into mature CD4+CD8- and CD4-CD8+ cells expressing a high density of T-cell receptors and CD3 molecules. Second, CsA-treated mice show incomplete deletion of T cells expressing T-cell receptor molecules reactive to self H-2 I-E molecules. 相似文献
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