Degrees of longitude and the earth's shape: The diffusion of a scientific idea in Paris in the 1730s

The paper deals with the confusion that has arisen in studying the revival of geodesy in Paris in the 1730s. The episode highlights the vast qualitative differences in science-reporting to be found in periodicals of the early eighteenth century, and the actual roles that certain better-known journals played in the genesis of what became a trademark for eighteenth-century Parisian science.     

Re-orienting discussions of scientific explanation: A functional perspective

Philosophy of science offers a rich lineage of analysis concerning the nature of scientific explanation, but the vast majority of this work, aiming to provide an analysis of the relation that binds a given explanans to its corresponding explanandum, presumes the proper analytic focus rests at the level of individual explanations. There are, however, other questions we could ask about explanation in science, such as: What role(s) does explanatory practice play in science? Shifting focus away from explanations, as achievements, toward explaining, as a coordinated activity of communities, the functional perspective aims to reveal how the practice of explanatory discourse functions within scientific communities given their more comprehensive aims and practices. In this paper, I outline the functional perspective, argue that taking the functional perspective can reveal important methodological roles for explanation in science, and consequently, that beginning here provides resources for developing more adequate responses to traditional concerns. In particular, through an examination of the ideal gas law, I emphasize the normative status of explanations within scientific communities and discuss how such status underwrites a compelling rationale for explanatory power as a theoretical virtue.     

Towards a typology of experimental errors: An epistemological view

This paper is concerned with the problem of experimental error. The prevalent view that experimental errors can be dismissed as a tiresome but trivial blemish on the method of experimentation is criticized. It is stressed that the occurrence of errors in experiments constitutes a permanent feature of the attempt to test theories in the physical world, and this feature deserves proper attention. It is suggested that a classification of types of experimental error may be useful as a heuristic device in studying the nature of these errors. However, the standard classification of systematic and random errors is mathematically based does not focus on the causes of the errors, their origins, or the contexts in which they arise. A new typology of experimental errors is therefore proposed whose criterion is epistemological. This typology reflects the various stages that can be discerned in the execution of an experiment, each stage constituting a category of a certain type of experimental error. The proposed classification consists of four categories which are illustrated by historical cases.     

The Munsell Color System: A scientific compromise from the world of art

Color systems make accurate color specification and matching possible in science, art, and industry by defining a coordinate system for all possible color perceptions. The Munsell Color System, developed by the artist Albert Henry Munsell in the early twentieth century, has influenced color science to this day. I trace the development of the Munsell Color System from its origins in the art world to its acceptance in the scientific community.Munsell's system was the first to accurately and quantitatively describe the psychological experience of color. By considering the problems that color posed for Munsell's art community and examining his diaries and published material, I conclude that Munsell arrived at his results by remaining agnostic as to the scientific definition of color, while retaining faith that color perceptions could be objectively quantified. I argue that Munsell was able to interest the scientific community in his work because color had become a controversial topic between physicists and psychologists. Parts of Munsell's system appealed to each field, making it a workable compromise. For contrast, I suggest that three contemporary scientists with whom Munsell had contact – Wilhelm Ostwald, Ogden Rood, and Edward Titchener – did not reach the same conclusions in their color systems because they started from scientific assumptions about the nature of color.     

The objectivity of scientific measures

The fundamental constants of nature, as presented by modern science, can be conceived as natural measures of the universe. In comparison, the standards of the International System of Units, including the kilogram and the meter, are mind-made and hand-crafted to meet the demands of human life. In this paper, the gap between the natural and the conventional is squeezed from two directions. In the first place, we come to understand why the metric measures were originally conceived, by the best of scientists, as being “taken from nature” and “in no way arbitrary”. The kilogram of yesteryear was anchored in yesteryear's science and is reasonably considered natural with respect to that science. We also review a contemporary debate amongst physicists that questions whether any quantity, being necessarily written with units, can be truly fundamental. Modern notions of a fundamental constant are put under the spotlight; the kilogram emerges as bound up with contemporary science today as ever it was. In the picture being painted here, our measures are drawn as dynamic entities, epistemic tools that develop hand-in-hand with the rest of science, and whose significance goes much further than a metal artefact dangled from an abstract number line.     

Agar diffusion plates: The recording of experimental data

Zusammenfassung Ein Auswertungsverfahren der Antigen-Antikörper-Analyse mittels der Geléediffusionsmethode vonOuchterlony wird beschrieben.Die Muster des Niederschlags im Versuch werden angefärbt und der Agar-Gelée-Nährboden mit dem Muster wird durch Austrocknung konserviert.So gefärbte und getrocknete Präparate können, visuell geprüft, als Negative oder Diapositive verwendet werden.     

The ontic conception of scientific explanation

Wesley Salmon's version of the ontic conception of explanation is a main historical root of contemporary work on mechanistic explanation. This paper examines and critiques the philosophical merits of Salmon's version, and argues that his conception's most fundamental construct is either fundamentally obscure, or else reduces to a non-ontic conception of explanation. Either way, the ontic conception is a misconception.     

Repertoires: A post-Kuhnian perspective on scientific change and collaborative research

We propose a framework to describe, analyze, and explain the conditions under which scientific communities organize themselves to do research, particularly within large-scale, multidisciplinary projects. The framework centers on the notion of a research repertoire, which encompasses well-aligned assemblages of the skills, behaviors, and material, social, and epistemic components that a group may use to practice certain kinds of science, and whose enactment affects the methods and results of research. This account provides an alternative to the idea of Kuhnian paradigms for understanding scientific change in the following ways: (1) it does not frame change as primarily generated and shaped by theoretical developments, but rather takes account of administrative, material, technological, and institutional innovations that contribute to change and explicitly questions whether and how such innovations accompany, underpin, and/or undercut theoretical shifts; (2) it thus allows for tracking of the organization, continuity, and coherence in research practices which Kuhn characterized as ‘normal science’ without relying on the occurrence of paradigmatic shifts and revolutions to be able to identify relevant components; and (3) it requires particular attention be paid to the performative aspects of science, whose study Kuhn pioneered but which he did not extensively conceptualize. We provide a detailed characterization of repertoires and discuss their relationship with communities, disciplines, and other forms of collaborative activities within science, building on an analysis of historical episodes and contemporary developments in the life sciences, as well as cases drawn from social and historical studies of physics, psychology, and medicine.     

The endocrine role for chromogranin A: A prohormone for peptides with regulatory properties

Chromogranin A (CgA) belongs to the granin family of uniquely acidic secretory proteins co-stored and co-secreted with other hormones and peptides in elements of the diffuse neuroendocrine system. The granins arise from different genes and are characterized by numerous sites for post-translational cleavage into shorter peptides with postulated regulatory properties. This review is directed towards endocrine aspects of CgA and its biologically active peptides. There is ample evidence from in vitro studies of distinct effects and targets for three CgA-derived peptides, vasostatin-I, pancreastatin and catestatin. Endocrine regulations are indicated from in vivo studies, consistent with the postulated prohormone function of CgA for peptides with regulatory properties. Most of the effects fit into patterns of direct or indirect, inhibitory modulations of major functions, implicating CgA peptides in regulation of calcium and glucose metabolism, cardiovascular functions, gastrointestinal motility and nociception, tissue repair, inflammatory responses and as host defense peptides in the first phase of microbial invasions. Received 1 June 2007; received after revision 11 July 2007; accepted 12 July 2007     

The effects of ethanol on embryonic actin: A possible role in teratogenesis

Summary When the neural crest is cultured in the long or short term presence of ethanol, monoclonal anti-actin reveals the development of a disorganized actin cytoskeleton. In the long term, many cells fail to differentiate morphologically, whereas in the short term already differentiated cells rapidly alter their shape and their cell-to-cell contacts.     

A comparison of two models of scientific progress

Does science progress toward some goal or merely away from primitive beginnings? Two agent-based models are built to explain how possibly both kinds of progressive scientific change can result from the interactions of individuals exploring an epistemic landscape. These models are shown to result in qualitatively different predictions about what the resulting system of science should be like.     

The birth of modern science: culture, mentalities and scientific innovation

In a recent paper, Luc Faucher and others have argued for the existence of deep cultural differences between ‘Chinese’ and ‘East Asian’ ways of understanding the world and those of ‘ancient Greeks’ and ‘Americans’. Rejecting Alison Gopnik’s speculation that the development of modern science was driven by the increasing availability of leisure and information in the late Renaissance, they claim instead—following Richard Nisbett—that the birth of mathematical science was aided by ‘Greek’, or ‘Western’, cultural norms that encouraged analytic, abstract and rational theorizing. They argue that ‘Chinese’ and ‘East Asian’ cultural norms favoured, by contrast, holistic, concrete and dialectical modes of thinking. After clarifying some of the things that can be meant by ‘culture’ and ‘mentality’, the present paper shows that Faucher and his colleagues make a number of appeals—to the authority of comparative studies and history of science, to the psychological studies of Nisbett and his colleagues, and to a hidden assumption of strong cultural continuity in the West. It is argued that every one of these appeals is misguided, and, further, that the psychological findings of Nisbett and others have little bearing on questions concerning the origins of modern science. Finally, it is suggested that the ‘Needham question’ about why the birth of modern science occurred in Europe rather than anywhere else is itself multiply confused to the extent that it may express no significant query.     

Judgement aggregation in scientific collaborations: The case for waiving expertise

The fragmentation of academic disciplines forces individuals to specialise. In doing so, they become experts over their narrow area of research. However, ambitious scientific projects, such as the search for gravitational waves, require them to come together and collaborate across disciplinary borders. How should scientists with expertise in different disciplines treat each others’ expert claims? An intuitive answer is that the collaboration should defer to the opinions of experts. In this paper we show that under certain seemingly innocuous assumptions, this intuitive answer gives rise to an impossibility result when it comes to aggregating the beliefs of experts to deliver the beliefs of a collaboration as a whole. We then argue that when experts’ beliefs come into conflict, they should waive their expert status.