Knowledge transfer without knowledge? The case of agentive metaphors in biology

Are scientific metaphors dispensable shortcuts that encapsulate knowledge but can always be translated back? Or do they constitute cases of knowledge transfer, even if seemingly based on scientifically underdeveloped domains? This paper defends the latter view. By drawing on the linguistic theories of metaphors, we assess a variety of agentive metaphors that pervade biology. Intentional metaphors are found unsatisfying because their use is either rigid or too widely flexible. By contrast, rational agent metaphors constitute good scientific metaphors, displaying flexible use and heuristic fruitfulness. Their range of application constantly evolves because they provide guidelines that permit the exploration of the applicability of source domain in a target domain. Their unique heuristic value makes them akin to research programs and allows for knowledge transfer, because they are based on a proper scientific source domain rather than on a folk or underdeveloped one.     

Theoretical construction in physics – The role of Leibniz for Weyl's ‘Philosophie der Mathematik und Naturwissenschaft’

This paper aims at closing a gap in recent Weyl research by investigating the role played by Leibniz for the development and consolidation of Weyl's notion of theoretical (symbolic) construction. For Weyl, just as for Leibniz, mathematics was not simply an accompanying tool when doing physics—for him it meant the ability to engage in well-guided speculations about a general framework of reality and experience. The paper first introduces some of the background of Weyl's notion of theoretical construction and then discusses particular Leibnizian inheritances in Weyl's ‘Philosophie der Mathematik und Naturwissenschaft’, such as the general appreciation of the principles of sufficient reason and of continuity. Afterwards the paper focuses on three themes: first, Leibniz's primary quality phenomenalism, which according to Weyl marked the decisive step in realizing that physical qualities are never apprehended directly; second, the conceptual relation between continuity and freedom; and third, Leibniz's notion of ‘expression’, which allows for a certain type of (surrogative) reasoning by structural analogy and which gave rise to Weyl's optimism regarding the scope of theoretical construction.     

The case of the composite Higgs: The model as a “Rosetta stone” in contemporary high-energy physics

This paper analyses the practice of model-building “beyond the Standard Model” in contemporary high-energy physics and argues that its epistemic function can be grasped by regarding models as mediating between the phenomenology of the Standard Model and a number of “theoretical cores” of hybrid character, in which mathematical structures are combined with verbal narratives (“stories”) and analogies referring back to empirical results in other fields (“empirical references”). Borrowing a metaphor from a physics research paper, model-building is likened to the search for a Rosetta stone, whose significance does not lie in its immediate content, but rather in the chance it offers to glimpse at and manipulate the components of hybrid theoretical constructs. I shall argue that the rise of hybrid theoretical constructs was prompted by the increasing use of nonrigorous mathematical heuristics in high-energy physics. Support for my theses will be offered in form of a historical–philosophical analysis of the emergence and development of the theoretical core centring on the notion that the Higgs boson is a composite particle. I will follow the heterogeneous elements which would eventually come to form this core from their individual emergence in the 1960s and 1970s, through their collective life as a theoretical core from 1979 until the present day.     

Thiamine pyrophosphate: An essential cofactor for the α-oxidation in mammals – implications for thiamine deficiencies?

The identification of 2-hydroxyphytanoyl-CoA lyase (2-HPCL), a thiamine pyrophosphate (TPP)-dependent peroxisomal enzyme involved in the α-oxidation of phytanic acid and of 2-hydroxy straight chain fatty acids, pointed towards a role of TPP in these processes. Until then, TPP had not been implicated in mammalian peroxisomal metabolism. The effect of thiamine deficiency on 2-HPCL and α-oxidation has not been studied, nor have possible adverse effects of deficient α-oxidation been considered in the pathogenesis of diseases associated with thiamine shortage, such as thiamine-responsive megaloblastic anemia (TRMA). Experiments with cultured cells and animal models showed that α-oxidation is controlled by the thiamine status of the cell/tissue/organism, and suggested that some pathological consequences of thiamine starvation could be related to impaired α-oxidation. Whereas accumulation of phytanic acid and/or 2-hydroxyfatty acids or their α-oxidation intermediates in TRMA patients given a normal supply of thiamine is unlikely, this may not be true when malnourished. Received 23 December 2005; received after revision 10 April 2006; accepted 28 April 2006     

The publication strategies of Jöns Jacob Berzelius (1779–1848): negotiating national and linguistic boundaries in chemistry

SUMMARY

This article follows the publication strategies of the Swedish chemist Jöns Jacob Berzelius (1779–1848). It focuses on the role of language and translation in Berzelius' efforts to strengthen his own reputation, and that of Swedish science. As an author and editor, Berzelius encouraged the translation of his own works into several languages, while endeavouring to preserve the status of Swedish as a language of scientific publication in the face of French, and increasingly German and English, dominance. Reforming the Transactions of the Royal Swedish Academy of Sciences and launching several new scientific periodicals, Berzelius also attempted to influence the publication practices in other countries.

Recent scholarship on the history of scientific publication has drawn attention to the practical difficulties of determining and getting hold of the relevant publications in one's field, the ‘malleability’ of the journal medium, and the common practice of reprinting and summarising papers published elsewhere. Berzelius’ publication strategies highlight translation – time-consuming, unreliable and problematic in terms of authorisation and ownership – as one aspect of the wider problem of communicating across national and linguistic boundaries. Berzelius' struggles with the practicalities of communicating across borders in times of war, the choice of language and its consequences, and national standards of publication, demonstrate the importance of a transnational perspective on the history of scientific publication.     

The quest for the size of the universe in early relativistic cosmology (1917–1930)

Before the discovery of the expanding universe, one of the challenges faced in early relativistic cosmology was the determination of the finite and constant curvature radius of space-time by using astronomical observations. Great interest in this specific question was shown by de Sitter, Silberstein, and Lundmark. Their ideas and methods for measuring the cosmic curvature radius, at that time interpreted as equivalent to the size of the universe, contributed to the development of the empirical approach to relativistic cosmology. Their works are a noteworthy example of the efforts made by modern cosmologists toward the understanding of the universe as a whole, its properties, and its content.     

The modernity of Dedekind’s anticipations contained in What are numbers and what are they good for?

Archive for History of Exact Sciences - We show that Dedekind, in his proof of the principle of definition by mathematical recursion, used implicitly both the concept of an inductive cone from an...     

Correction to: The modernity of Dedekind’s anticipations contained in What are numbers and what are they good for?

Archive for History of Exact Sciences - The original version of this article unfortunately contained a mistake: The equation on page 34 was incorrect. The corrected equation is given below.     

The epididymis-specific antimicrobial peptide β-defensin 15 is required for sperm motility and male fertility in the rat (<Emphasis Type="Italic">Rattus norvegicus</Emphasis>)

Spermatozoa acquire forward motility and fertilizing capacity during their transit through the epididymis. The maturation process involves modifications of the sperm surface by different proteins that are secreted by a series of specialized regions in the epididymal epithelium. Here we show that the rat epididymis-specific β-defensin 15 (Defb15) exhibits an androgen-dependent expression pattern, and it can bind to the acrosomal region of caput sperm. Coculture of caput spermatozoa with Defb15 antibody in vitro resulted in a significant decline in sperm motility. Moreover, the total and progressive motility of the spermatozoa dramatically decreased in rats when Defb15 was downregulated by lentivirus-mediated RNAi in vivo. Remarkably, knock down of Defb15 led to a reduction in fertility and embryonic development failure. In addition, the recombinant Defb15 showed antimicrobial activity in a dose-dependent fashion. These results suggest that Defb15 plays a dual role in both sperm maturation and pathogen defense in rat epididymis.