共查询到20条相似文献,搜索用时 256 毫秒
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P Leroux M Gredt 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1978,286(5):427-429
Imazalil is a new fungicide effective against Penicillium molds on fruits after harvest. This compound inhibits ergosterol biosynthesis in mycelia of Penicillium expansum. The accumulation of 24--methylenedithydrolanosterol, obtusifoliol and 14 alpha-methyl-delta 8, 24(28)-ergostadienol in treated fungi suggests that imazalil blocks sterol C--14 demethylation. 相似文献
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J Y Detaille C G Caillard S Mondot J C Louis L Julou 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(5):555-558
In the Dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (RS, SR) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. Furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. The first clinical studies of this compound have shown its usefulness in the treatment of ventricular and supraventricular arrhythmias. 相似文献
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P Tchen J Seger P Grenand E Bois 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1978,286(24):1817-1820
Two small populations of inner French Guiana were investigated for red cell enzymes and serum proteins. Rare variants were found in four systems (AK1, PGM1, PGM2, Tf). Similarities between some of these variants and those found in other Amerindian populations indicate that these genetic markers may be valuable in studies of Amerindians. A mutation rate has been estimated from the results. 相似文献
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H. Nakamura K. Ishii Y. Yokoyama S. Motoyoshi C. Imazu M. Shimizu 《Cellular and molecular life sciences : CMLS》1979,35(3):369-370
Summary dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals. 相似文献
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Schaefer U Schneider A Rudroff C Neugebauer E 《Cellular and molecular life sciences : CMLS》2003,60(9):1968-1981
During agonist-dependent long-term stimulation of cells, histamine receptor subtypes are frequently down-regulated. However, the mechanisms underlying the modulation of receptor expression during long-term histamine stimulation have yet to be resolved. Based on our recently reported results showing an H1-mediated down-regulation of histamine H2 receptor mRNA in endothelial cells, our aim was to characterize the mechanism controlling rapid and long-term histamine-mediated modulation of H2 receptor expression in more detail. We were able to show that the histamine-induced down-regulation of H2 receptor mRNA and cell surface expression lasting for 24 h was accompanied by augmentation of the receptor protein level in the cytoplasmatic fraction of endothelial cells for this time period. Furthermore, changes in receptor protein levels in whole-cell lysate were negligible, indicating that the rapid and prolonged modulation of cell surface H2 receptor levels by histamine was regulated solely via internalization. The role of nitric oxide (NO) as a key mediator in histamine-stimulated cell responses was underlined by subsequent studies showing the attenuation of histamine-induced H2 receptor mRNA down-regulation and protein trafficking following NO synthase isozyme inhibition.Received 11 March 2003; received after revision 11 June 2003; accepted 17 June 2003 相似文献
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dl-Erythro-1-phenyl-2-(o-chlorophenyl)-2-[4-(p-methoxybenzyl)-1-piperazinyl] ethanol dihydrochloride showed orally a definite analgesic activity, without producing the significant morphine-like physical dependence liability, and its analgesic potency was about a half that of codeine and far superior to aminopyrine in experimental animals. 相似文献
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An increase in circulating asymmetric dimethylarginine (ADMA) and a decreased L-arginine/ADMA ratio are associated with reduced
endothelial nitric oxide (NO) production and increased risk of vascular disease. We explored relations between ADMA, L-arginine
and dimethylarginine dimethylaminohydrolase (DDAH) in liver (HepG2) cells. DDAH is the principle enzyme for the metabolism
of ADMA. HepG2 cells metabolised 44.8 nmol/h of ADMA per 3.6 × 106 cells in the absence of L-arginine. The metabolism of ADMA at physiological (1μ mol/l, p < 0.01) and at pathological (100μmol/l,
p < 0.01) levels was inhibited dose-dependently by L-arginine (0–400μmol/l) in cultured HepG2 cells and increased intracellular
ADMA (p = 0.039). L-arginine competitively inhibited DDAH enzyme activity to 5.6 ± 2.0% of the untreated level (p < 0.01).
We conclude that L-arginine regulates ADMA metabolism dose-dependently by competing for DDAH thus maintaining the metabolic
balance of L-arginine and ADMA, and endothelial NO homeostasis.
Received 9 June 2006; received after revision 16 July 2006; accepted 19 September 2006 相似文献
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D. L. Smalley 《Cellular and molecular life sciences : CMLS》1982,38(12):1483-1484
Summary 7 strains ofPseudomonas paucimobilis and 7 strains ofFlavobacterium multivorum (formerly groups IIK biotype 1 and biotype 2, respectively) showed endotoxin-like activity in vitro by the limulus amoebocyte lysate test. 相似文献
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R. K. Razdan A. J. Puttick B. A. Zitko G. R. Handrick 《Cellular and molecular life sciences : CMLS》1972,28(2):121-122
Zusammenfassung Die Synthese von (—)-1(7)-Tetrahydrocannabinol (THC) auf (—)-1(6) wird beschrieben. Das Hauptprodukt der oxidativen Zerstörung von (—)-1-THC ist Cannabinol. Beschleunigte Versuche der Luftoxidation von (—)-1-THC und (—)-1(6)-THC haben gezeigt, dass das letztere beständiger ist. Dieser Unterschied kann mit der Reaktivität des C3-benzylisch-allylischen Wasserstoffes in (—)-1-THC erklärt werden. 相似文献
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M. L. BeÇak R. F. Batistic L. D. Vizotto W. BeÇak 《Cellular and molecular life sciences : CMLS》1969,25(1):81-83
Resumen En el murciélagoArtibeus lituratus lituratus el nÚmero de cromosomas es de 2n=30 en la hembra y de 2n=31 en el macho. El mecanismo de determination del sexo esXX/XY
1Y2. La translocación de un autosoma alX resultó en la diferenciación del neo-Y. Son descritos los aspectos del comportamiento del trivalente sexual durante la meiosis. Estos son comparados a los que presenta la especieNoctilio leporinus (2n=34) cuyo mecanismo esXX/X Y.
This work was supported by Public Health Service Research Grant No. GM-14577-03 from the National Institute of General Medical Sciences and by the Fundo de Pesquisas do Instituto Butantan. R. F. B. holds a FAPESP training fellowship. 相似文献
This work was supported by Public Health Service Research Grant No. GM-14577-03 from the National Institute of General Medical Sciences and by the Fundo de Pesquisas do Instituto Butantan. R. F. B. holds a FAPESP training fellowship. 相似文献
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Zhang Y Yu G Wang Y Xiang Y Gao Q Jiang P Zhang J Lee W Zhang Y 《Cellular and molecular life sciences : CMLS》2011,68(22):3771-3780
Trefoil factors (TFFs) promote epithelial cell migration to reseal superficial wounds after mucosal injury, but their receptors
and the molecular mechanisms underlying this process are poorly understood. In this study, we showed that frog TFF2 activates
protease-activated receptor (PAR) 1 to induce human platelet aggregation. Based on this result, we further tested the involvement
of PARs in human TFF2 (hTFF2)-promoted mucosal healing. hTFF2-stimulated migration of epithelial HT-29 cells was largely inhibited
by PAR4 depletion with small interfering RNAs but not by PAR1 or PAR2 depletion. The PAR4-negative epithelial cell lines AGS
and LoVo were highly responsive to hTFF2 as assessed by phosphorylation of ERK1/2 and cell migration upon PAR4 expression.
Our findings suggest that hTFF2 promotes cell migration via PAR4. These findings will be helpful in further investigations
into the functions and molecular mechanisms of TFFs and PARs in physiology and disease. 相似文献