Serum antiheparin activity in chronic renal failure

Zusammenfassung Die Antiheparinaktivität des Blutserums bei Personen mit chronischer Niereninsuffizienz erweist sich statistisch gesichert niedriger als bei Gesunden (P<0,001). Der Befund scheint auf einen Zusammenhang mit dem funktionellen Zustand der Thrombocyten hinzuweisen.     

Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure

Summary The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.     

Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure

The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.     

Effect of experimental allergic encephalomyelitis γ-globulin upon the electrical activity of the brain

Zusammenfassung Die direkte Wirkung eines-Globulin-Präparates aus Kaninchenserum (Injektion in laterale Hirnkammer des Kaninchens) auf die experimentelle allergische Encephylomyelitis wurde dargestellt und elektroencephalographisch eine Inaktivierung verschiedener Hirnregionen festgestellt.     

Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure

The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.     

Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure

Summary The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.     

Adjuvant activity of ricin as measured by Jerne's plaque technique

Zusammenfassung Es wird gezeigt, dass Injektion von Rizinus-Extrakt die Plaque-Bildung im Jerne-Test fördert, was dafür spricht, dass die zytostatische Wirkung des Rizinus mit der Adjuvansfähigkeit gekoppelt ist.

---

---

We are greatly indebted to Drs. M.Funatsu and G.Funatsu for their supply for ricin and to Miss Y.Nagakawa for her excellent technical assistance.     

Lithium effects upon components of activity in rats

Summary When lithium chloride was administered to rats several changes occurred in a number of components of activity, some of which were sex-related. There was a reduction in both ambulatory and rearing activity and in behaviour associated particularly with the mouth and nose. The findings are related to a suggestion that lithium effects on behaviour may be more subtherthan hitherto thought.     

Effect of fluoride administration on renal glucose-6-phosphatase activity in rats

Renal glucose-6-phosphatase activity was found to be significantly elevated by fluoride administration (NaF 35 mg/kg, i.p.). The elevation of the enzyme activity was markedly suppressed by adrenalectomy.     

Effect of fluoride administration on renal glucose-6-phosphatase activity in rats

Summary Renal glucose-6-phosphatase activity was found to be significantly elevated by fluoride administration (NaF 35 mg/kg, i.p.). The elevation of the enzyme activity was markedly suppressed by adrenalectomy.This work was supported in part by the Scientific Research Foundation (Grant 7014-267337) from the Education and Culture Ministry of Japan.     

Leukocyte mobilization by epinephrine and hydrocortisone in patients with chronic renal failure

Summary The mobilization of WBC from the bone marrow, as judged from hydrocortisone-induced leucocytosis, is markedly impaired in dialyzed and nondialyzed uremic patients. The release of WBC from the marginal pool by epinephrine was found to be normal.     

Kallikrein-like activity in the urine of renal hypertensive rats

Résumé La ligature «en figure huit» d'un rein suivie de l'ablation de l'organ contrelatéral, est accompagnée d'une remarquable amoindrissement de l'activité kallikreine urinaire pourvu que les animaux développent une pression artérielle permanente et élevée.     

Lithium effects upon components of activity in rats.

When lithium chloride was administered to rats several changes occurred in a number of components of activity, some of which were sex-related. There was a reduction in both ambulatory and rearing activity and in behaviour associated particularly with the mouth and nose. The findings are related to a suggestion that lithium effects on behaviour may be more subtle than hitherto thought.     

Effect of insulin upon renal amino acid transport in lambs

Zusammenfassung An Nierenrindenschnitten von Lämmern und Schafen wurde untersucht, ob die Anwesenheit von Insulin bzw. Glukagon im Inkubationsmedium die gegen ein Konzentrationsgefälle erfolgende Aufnahme von -Aminoisobuttersäure in Nierenrindenzellen beeinflusst. Insulin stimulierte in diesen Versuchen (Inkubationszeit: 80 min) die Akkumulation von -Aminoisobuttersäure in Nierenrindenzellen bei jungen Lämmern, nicht jedoch bei älteren Lämmern und Schafen. Für Glukagon konnte kein Effekt nachgewiesen werden.

---

---

Acknowledgment. The investigation was supported by the Deutsche Forschungsgemeinschaft (SFB 147 Jungtierkunde).     

Changes in alanine transaminase activity in the liver of riboflavin-deficient rats

Zusammenfassung 45tägiger Riboflavinmangel bewirkte bei männlichen Albinoratten in der Leber eine Erhöhung der Alanin-Transaminase-Aktivität sowie des Pyridoxal- und Glykogengehaltes. Diese Befunde weisen darauf hin, dass die Aktivität der Nebennierenrinde beim Riboflavinmangel erhöht ist.

---

---

Acknowledgment: The authors wish to express their sincere gratitude to Prof. S. R.Maitra, Head of the Department of Physiology, Calcutta University, for constant encouragement and for providing the laboratory facilities. The authors are also thankful to Dr.D. Sen of the Department of Applied Chemistry, Calcutta University, for translating the English summary into German.     

The effect of various diuretic agents on renal electrolyte and urea concentration gradients in rats

Zusammenfassung Die Konzentrationsgradienten von Na+und Harnstoff im Rattennierengewebe werden durch intravenöse Applikation von Merallurid, Salyrgan und Hydrochlorothiazid nicht beeinflusst. Die Änderung des Na-Gradienten nach Aminophyllin hängt von der Injektionszeit ab. Acetazolamid-, Chlorothiazid- und Furosemid-Injektion führt jedoch zur Senkung oder zum Verschwinden eines Na-Gradienten. Die Kaliumkonzentration in der Rinde und Papilla wird durch Hg- und Sulfonamid-Diuretica erniedrigt.     

Effect of the administration of xanthine on the appearance of xanthine oxidase activity in the liver of growing rats

Riassunto La somministrazione di xantina a ratti di età compresa fra i 12 e i 30 giorni, causa una precoce comparsa di attività xantinossidasica. Tale comparsa è influenzata dalla cycloheximide ma non dal cortisone nè dalla attinomicina D.