共查询到20条相似文献,搜索用时 23 毫秒
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Recent studies have demonstrated a critical role for nerves in enabling tumor progression. The association of nerves with cancer cells is well established for a variety of malignant tumors, including pancreatic, prostate and the head and neck cancers. This association is often correlated with poor prognosis. A strong partnership between cancer cells and nerve cells leads to both cancer progression and expansion of the nerve network. This relationship is supported by molecular pathways related to nerve growth and repair. Peripheral nerves form complex tumor microenvironments, which are made of several cell types including Schwann cells. Recent studies have revealed that Schwann cells enable cancer progression by adopting a de-differentiated phenotype, similar to the Schwann cell response to nerve trauma. A detailed understanding of the molecular and cellular mechanisms involved in the regulation of cancer progression by the nerves is essential to design strategies to inhibit tumor progression. 相似文献
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Signal transduction via the stem cell factor receptor/c-Kit 总被引:6,自引:0,他引:6
Rönnstrand L 《Cellular and molecular life sciences : CMLS》2004,61(19-20):2535-2548
Together with its ligand, stem cell factor, the receptor tyrosine kinase c-Kit is a key controlling receptor for a number of cell types, including hematopoietic stem cells, mast cells, melanocytes and germ cells. Gain-of-function mutations in c-Kit have been described in a number of human cancers, including testicular germinomas, acute myeloid leukemia and gastrointestinal stromal tumors.Stimulation of c-Kit by its ligand leads to dimerization of receptors, activation of its intrinsic tyrosine kinase activity and phosphorylation of key tyrosine residues within the receptor. These phosphorylated tyrosine residues serve as docking sites for a number of signal transduction molecules containing Src homology 2 domains, which will thereby be recruited to the receptor and activated many times through phosphorylation by the receptor. This review discusses our current knowledge of signal transduction molecules and signal transduction pathways activated by c-Kit and how their activation can be connected to the physiological outcome of c-Kit signaling. 相似文献
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Tarik Regad 《Cellular and molecular life sciences : CMLS》2013,70(21):4055-4065
Melanoma is a malignant tumor of melanocytes that can spread to other organs of the body, resulting in severe and/or lethal malignancies. Melanocytes are pigment-producing cells found in the deep layer of the epidermis and are originated from melanocytes stem cells through a cellular process called melanogenesis. Several genes and epigenetic and micro-environmental factors are involved in this process via the regulation and maintenance of the balance between melanocytes stem cells proliferation and their differentiation into melanocytes. Dysregulation of this balance through gain or loss of function of key genes implicated in the control and regulation of cell cycle progression and/or differentiation results in melanoma initiation and progression. This review aims to provide a comprehensive overview about the origin of melanocytes, the oncogenic events involved in melanocytes stem cells transformation, and the mechanisms implicated in the perpetuation of melanoma malignant phenotype. 相似文献
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V Verma 《Experientia》1979,35(1):40-42
It is known that, in a denervated striated muscle, the satellite cells multiply by mitotic division. A liaison between these satellite cells and the Schwann cell in front of the post-synaptic membrane in denervated frog muscle has been observed. It is probable that such cell connections help in the subsistence of the Schwann cell in a denervated muscle. 相似文献
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Vinod Verma 《Cellular and molecular life sciences : CMLS》1979,35(1):40-42
Summary It is known that, in a denervated striated muscle, the satellite cells multiply by mitotic division. A liaison between these satellite cells and the Schwann cell in front of the post-synaptic membrane in denervated frog muscle has been observed. It is probable that such cell connections help in the subsistence of the Schwann cell in a denervated muscle. 相似文献
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Olfactory ensheathing cells have been used in several studies to promote repair in the injured spinal cord. However, cellular
interaction between olfactory ensheathing cells and glial cells induced to be reactive in the aftermath of injury site has
not been investigated. Using an in vitro model of astrogliosis, we show that reactive astrocytes expressed significantly less glial fibrillary acidic protein (GFAP)
when cultured both in direct contact with olfactory ensheathing cells and when the two cell types were separated by a porous
membrane. Immunofluorescence staining also suggested that reactive astrocytes showed decreased chondroitin sulfate proteoglycans
in the presence of olfactory ensheathing cells, although the reduction was not statistically significant. No down-regulation
of GFAP was observed when reactive astrocytes were similarly cultured with Schwann cells. Cell viability assay and bromodeoxyuridine
uptake showed that proliferation of reactive astrocytes was significantly increased in the presence of olfactory ensheathing
cells and Schwann cells.
Received 27 February 2007; received after revision 30 March 2007; accepted 3 April 2007 相似文献
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The processing and presentation of endogenous and exogenous antigen by Schwann cells in vitro 总被引:1,自引:0,他引:1
Lilje O 《Cellular and molecular life sciences : CMLS》2002,59(12):2191-2198
The expression of major histocomatibility complex class II in vitro and in vivo by Schwann cells indicates a potential facultative
role of Schwann cells in the presentation of antigen to neuritogenic T cells during inflammatory demyelinating neuropathies.
Using a T cell proliferation assay, this study demonstrated that processing and presentation of endogenous and exogenous antigen
by Schwann cells influences T cell proliferation. Statistical analysis of proliferation and its relation to processing and
presentation of antigen by Schwann cells had not been previously addressed. Different combinations of factors including treatment
of cultures (untreated, irradiated or fixed), concentration of exogenous antigen (0 or 40 μmg/ml), the presence of interferon-γ
and the timing of exogenous antigen addition influence the proliferation P2-specific, non-mammalian protein ovalbumin-specific T cell lines and naive T cells.
Received 25 July 2002; received after revision 9 September 2002; accepted 7 October 2002 相似文献
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In suckling mice injected with steroids, multiple tumors occurred in the sites where neural crest cells normally are present. It is speculated that the phase of the cell cycle of the neural crest cells may have something to do with its cell surface and cellular phenotypic expression in the system mediated by cyclic AMP. 相似文献
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Summary In suckling mice injected with steroids, multiple tumors occurred in the sites where neural crest cells normally are present. It is speculated that the phase of the cell cycle of the neural crest cells may have something to do with its cell surface and cellular phenotypic expression in the system mediated by cyclic AMP. 相似文献
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L. C. U. Junqueira G. S. Montes M. S. F. Bezerra 《Cellular and molecular life sciences : CMLS》1979,35(1):114-114
Summary The fact that collagen from both normal nerve endoneurium and Schwann cell tumours present characteristics of collagen type III, suggests that Schwann cells produce this type of collagen. 相似文献
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T Nozue 《Experientia》1978,34(10):1347-1349
In suckling mice injected i.p. with a 27 mg/kg dose of L-hydrochloric acid isoproterenol, multiple neural crest tumors developed and cell death of neural crest cells occurred. It is speculated that neural crest derivatives may be beta-receptor cells and contain regulatory units of neurotransmission mediated through cyclic AMP. 相似文献
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B. Iyengar 《Cellular and molecular life sciences : CMLS》1994,50(7):669-672
Whole skin organ cultures of vitiliginous, skin show that the marginal melanocytes are highly sensitive to a pulse of UV exposure (210–380 nm) during the G2 phase of the cell cycle, as seen by prominent dendricity. Melanocytes are highly dendritic in the epidermis overlying rapidly growing tumors, as well as within proliferative lesions such as basal cell carcinomas and aggressive seborrheic keratosis. In the organ cultures the dendrites extend towards the source of UV, i.e. the surface, while the main body lies along the basement membrane. The epidermal melanocytes overlying tumors lie, almost vertically, dendrites aligned towards the underlying tumor on one side and the surface on the other. Within tumors dendritic elongation is guided by mitotic and PCNA positive (S-phase) tumor cells, which are a source of ultraweak UV emissions in the range of 210–330 nm. These observations indicate that ultraweak biophoton emissions from neighbouring cells can simulate environmental cues and contribute to the plasticity of networks such as the melanocytes or the visual pathways. 相似文献
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H. U. Koecke 《Cellular and molecular life sciences : CMLS》1957,13(7):294-295
Summary The first melanocytes in the duck (Khaki Campbell) appear after an incubation period of 88 h (about 40 somites) in the otic region. The melanoblasts of that region can be traced back to cells of the rhombencephalic neural crest of the 17-somites stage.
Das Untersuchungsmaterial wurde während des Aufenthaltes am Hubrecht-Laboratorium in Utrecht anlässlich des Second International Teamwork gesammelt. Zur Durchführung der Untersuchungen standen Mittel der Deutschen Forschungsgemeinschaft zur Verfügung. 相似文献
Das Untersuchungsmaterial wurde während des Aufenthaltes am Hubrecht-Laboratorium in Utrecht anlässlich des Second International Teamwork gesammelt. Zur Durchführung der Untersuchungen standen Mittel der Deutschen Forschungsgemeinschaft zur Verfügung. 相似文献
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Glejzer A Laudet E Leprince P Hennuy B Poulet C Shakhova O Sommer L Rogister B Wislet-Gendebien S 《Cellular and molecular life sciences : CMLS》2011,68(12):2101-2114
Recent studies have shown that neural crest-derived progenitor cells can be found in diverse mammalian tissues including tissues
that were not previously shown to contain neural crest derivatives, such as bone marrow. The identification of those "new" neural
crest-derived progenitor cells opens new strategies for developing autologous cell replacement therapies in regenerative medicine.
However, their potential use is still a challenge as only few neural crest-derived progenitor cells were found in those new
accessible locations. In this study, we developed a protocol, based on wnt1 and BMP2 effects, to enrich neural crest-derived
cells from adult bone marrow. Those two factors are known to maintain and stimulate the proliferation of embryonic neural
crest stem cells, however, their effects have never been characterized on neural crest cells isolated from adult tissues.
Using multiple strategies from microarray to 2D-DIGE proteomic analyses, we characterized those recruited neural crest-derived
cells, defining their identity and their differentiating abilities. 相似文献
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T. Nozue 《Cellular and molecular life sciences : CMLS》1978,34(10):1347-1349
Summary In suckling mice injected i.p. with a 27 mg/kg dose of L-hydrochloric acid isoproterenol, multiple neural crest tumors developed and cell death of neural crest cells occurred. It is speculated that neural crest derivatives may be -receptor cells and contain regulatory units of neurotransmission mediated through cyclic AMP. 相似文献
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C Aubert F Rougé J R Galindo 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(10):919-922
A morphological, caryological and biochemical study of two established cell lines of human malignant melanocytes derived from the same original tumour, when compared with heterotransplantation results in nude Mice, showed that "non-pigmented" cells are more tumorigenic than pigmented cells. Differentiation and tumorigenicity, although concomitant, here seem to be two independent phenomena. 相似文献