Abtransport von Schwefelverbindungen aus Bohnenprimärblättern (Phaseolus vulgaris) nach Begasung mit H2 35S

Summary Some unnatural sulphur amino acids can be detected in the phloem of the vascular bundles from Phaseolus vulgaris after the application of H₂ ³⁵S to the primary leaves.     

Ultrastruktur der Symbionten in Ovozyten vonOrnithodorus moubata,Murray (Ixodoidea:Argasidae) nach simultaner Glutaraldehyd-Osmiumfixierung und Nachbehandlung mit Uranylacetat (Triple-Fixation)

Summary The nucleoplasm of rickettsia-like microorganisms living in the oocytes of the soft tickOrnithodorus moubata is preserved by TF (triple-fixation) in a fine fibrillary form, resembling the results obtained by the standard-method for DNA-containing plasms.

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Die Arbeit wurde vom Schweiz. Nationalfonds unterstützt.

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Frau S.Latscha-Stoller möchte ich für ihre unentbehrliche technische Mitarbeit meinen besten Dank aussprechen.     

Nachweis der Bisulfit-Addukte (α-Oxysulfonsäuren) von Carbonylverbindungen in den mit SO2 behandelten Erbsenkeimlingen

Summary The intoxication of 15-day-old green pea seedlings with 1% gaseous SO₂ causes an important concentration fall of some free ketoacids (pyruvic, oxalacetic, -ketoglutaric) and of glyceraldehyde in the roots and shoots. This fall is a consequence of the reaction of these carbonyl compounds with SO₂ in the plant tissue under the formation of bisulphite adducts (-hydroxysulfonic acids), which have been chemically proved and quantitatively estimated.     

Einbau von H3-thymidin in zellen und gewebe vonHelix pomatia L. (gastropoda,pulmonata)

Summary It has been demonstrated by injections of H³-Thymidine into adult and juvenile snails (Helix pomatia) that the mitotic activity in the central nervous system, the connective tissue and epidermis was generally higher in juvenile animals than in adult ones. Data are given for the amount of triated thymidine labelled nuclei in the tissues, which are investigated.     

Resorption von Serumproteinen in die Haemolymphe bei Larven vonHypoderma bovis (De Geer) (Diptera,Hypodermatidae)

Summary By electrophoresis it became obvious that larvae ofHypoderma bovis are able to take up complete proteins from their host's serum directly into the haemolymphe, fatbody and ovarium. This could be proved by experiments with radioactive albumin.     

Antiarrhythmic properties of 3-(2-hydroxy-3 isopropylamino-propoxy)-3 phenyl-2 isoindolinone-1, (RS, SR) in the dog]

In the Dog, 3-(2-hydroxy-3 isopropylamino-proxy)-2-phenyl-1-isoindolinone (RS, SR) possesses an anti-arrhythmic activity similar to that of quinidine but at dose levels 2 to 6 times lower than in the case of the latter compound. Furthermore, in contrast to quinidine, at the dose levels where the antiarrhythmic activity is well observed, the compound is devoid of hypotensive activity and of depressive action on cardiac contractility. The first clinical studies of this compound have shown its usefulness in the treatment of ventricular and supraventricular arrhythmias.     

Einbau von3H-Uridin in Follikelepithelzellen degenerierender Oozyten beim Zebrafisch,Brachydanio rerio (Ham. Buch.)

Summary The incorporation of tritiated uridine into the follicular epithelium of degenerating oocytes of the zebrafish,Brachydanio rerio, was studied by radio-autography. After incubation times from 1–12 h, the labelling of the follicular epithelial cells of degenerating oocytes was several times higher than in normal developing follicles. This indicates an increase of RNA-synthesis, probably necessary for the formation of lytic enzymes.     

Occurrence in mushrooms (Homobasidiomycetes) of cis- and trans-octa-1,5-dien-3-ol,attractants to the cheese miteTyrophagus putrescentiae (Schrank) (Acarina,Acaridae)

Summary Cis- and trans-octa-1,5-dien-3-ol were identified in 15 Homobasidiomycetes; these compounds exhibited a significant attraction for the cheese miteTyrophagus putrescentiae (Schrank) (Acarina, Acaridae).     

Die Veränderungen der Succinodehydrase-Aktivität in Detroit-6 (VA) Zellen,infolge der Infektion mit demHepatitis-infectiosa-Virus

Summary The inhibitory action ofHepatitis infectiosa virus on the SDH activity of Detroit-6 (VA) cell lines was investigated. The full inhibition of the SDH activity took place at the end of the third day after the infection. As this phenomenon precedes the cytopathogenetic effect of viral infection, it may be of some help in the early detection of the infection.     

Evidence of urinary glomerular basement membrane (GBM) antigens excretion in 3 rodents (rat, mouse, and guinea-pig) (author's transl)]

Immunodiffusion technique, with rabbits antibodies against rat glomerular basement membrane (GBM), permits to evidence the presence of GBM antigens into normal urines of 3 rodents (rat, mouse, and guinea-pig). These results confirm the earlier works in human and rabbit urines and show the antigenic communauty existing between the 3 rodents GBM, since we can evidence antigens of 3 different mammals with the same antibody. The origin and the nature of this patterns and the signification of this presence into mammalian urines are discussed.     

The accumulation of 3-Iodo N,N, Diacet-6 aminobenzoic acid (IDAB) in growth areas of bone

Résumé IDAB marqué avec Iode 131 était administré aux rats pour déterminer sa distribution entre les tissus des rats. On trouve que IDAB est accumulé selectivement par les parties croissantes des os. Deux ou trois jours après l'injection, l'activité spécifique des os était vingt fois plus grande que celle qui se trouve dans le sang.

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This investigation was supported by the James Picker Foundation on recommendation of the Committee on Radiology, National Academy of Sciences National Research Council, Washington.     

Zur Synthese des Batrachotoxinins: Synthese von 3β-Acetoxy-16β, 20β-dihydroxy-4′-methyl-18-nor-5β, 14β-pregnano[13,14-f]hexahydro-1′,4'-oxazepin-3′-on(20a)

Summary The synthesis of 3-acetoxy-16, 20-dihydroxy-4-methyl-18-nor-5, 14-pregnano[13,14-f]hexahydro-1, 4-oxazepin-3-one (20a) is described.     

3-Methylcholanthrene-induced embryonic deformities in the chick: Prevention by the antioxidant,N,N′-diphenyl-p-phenylene diamine (DPPD)

Résumé Les embryons de poulet traités au préalable par du N,N-diméthyl-p-phénylène diamine sont immunisés contre les déformations que produit le 3-méthylcholranthrène. Il est possible que cette protection soit due à une action neutralisante des radicaux libres formés par le 3-méthylcholranthrène avec l'oxygène.

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Fellowship support from the Tobacco Research Council.     

Hemolymph proteins in an ascitic condition,induced by lethal1(3)gl tumorous tissue inDrosophila hydei

Summary Drosophila hydei larvae homozygous for the gene1(3)gl may survive to the age of 3 weeks, become bloated and be incapable of metamorphosis. Wild-type flies after the injection of a fragment of the1(3)gl disc, which has been previously culture in vivo for 40–500 days, also become bloated (ascitic reaction). In the hemolymph of both the advanced1(3)gl larvae and ascitic adult hosts the accumulation of a specific protein is observed.Acknowledgments. This work was supported by the Swiss National Science Foundation under Grant No.3.792-0.76 and the Georges und Antoine Claraz-Schenkung. We thank Prof. H. Gloor, University of Geneva, and Prof. P.S. Chen, University of Zürich, for advice and criticism.     

Vitellogenin and lipovitellins inOrchestia gammarellus (pallas) (Crustacea,Amphipoda); labelling of subnuits after in vivo administration of3H-leucine

Summary The distribution of³H-leucine between the various polyopeptide components ofOrchestia gammarellus vitellogenin and lipovitellins, separated by SDS-PAGE, has been stdied after in vivo injection of this amino-acid. The results corroborate the view that, the heaviest components, or native polypeptide subunits of vitellogenin, are progressively transformed into lighter ones.     

The efficacy of a novel compound, (E)-1-(4′-bromo-4-biphenylyl)-1-(4-chlorophenyl)-3-dimethylaminoprop-1-ene againstTrypanosoma cruzi in mice

Summary The biological properties of a novel compound 353C with high activity againstTrypanosoma cruzi, are described. The compound was about 10 times and 20 times more effective than either benznidazole or nifurtimox respectively, in producing radical cure in mice. 353C had a long half-life and showed anti-trypanosomal properties when given to mice at weekly intervals.