共查询到11条相似文献，搜索用时 78 毫秒
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引起人非典型性肺炎的冠状病毒基因组与其它冠状病毒基因组的初步比较 总被引：4，自引：0，他引：4
一种在世界范围内突然爆发的致命流行病——急性呼吸窘迫综合症(SARS)击倒了数干人,一种全新的冠状病毒被认为是其病原．5个SARS相关冠状病毒的全基因组序列已经完成．我们进行了SARS相关冠状病毒和其它冠状病毒的基因组进化分析和序列比较,结果显示：1．SARS相关冠状病毒不直接来自于任何已知的冠状病毒;2．E蛋白的基因可能是在近期从其它病毒横向转移到SARS病毒中来的;3．Sl和S2基因发生了较大范围的缺失或插入突变．这些基因横向转移和突变改变了SARS相关病毒的表面结构和抗原性,极有可能是导致其获得侵染人类细胞的主要原因． 相似文献
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概述了SARS—CoV的S蛋白的结构及功能相关研究。严重急性呼吸综合症相关的冠状病毒(SARS-CoV)引起2003年我国南方非典型肺炎爆发流行,波及多个国家和地区。目前全球许多学对SARS-CoV进行了广泛的研究,发现S蛋白是病毒表面的主要蛋白,它构成冠状病毒科特征性的冠状样结构,在严重急性呼吸综合症的发病机制起着关键性作用,可介导表达相关受体的宿主细胞感染。现已鉴定出SARS-CoV的S蛋白相关受体,同时它在抗病毒感染中是一个关键靶蛋白。 相似文献
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JINWeiwu CHENChen ZHANGYing ZHAOYiqiang FENGJidong CHENFuyong WUQingming YANGHanchun WANGMing YUJialin LINing GONGYuanshi SUNQixin CHENZhangliang 《科学通报(英文版)》2004,49(6):585-590
Avian infectious bronchitis virus (AIBV) is classified as a member of the genus coronavirus in the family coronaviridae. The enveloped virus has a positive-sense, single-stranded RNA genome of approximately 28 kilo-bases,which has a 5‘ cap structure and 3‘ polyadenylation tract.The complete genome sequence of infectious bronchitis virus (IBV), Beijing isolate, was determined by cloning sequencing and primer walking. The whole genome is 27733 nucleotides in length, has ten open reading frames:5′-orfla-orflab-s-3a-3b-e-m- 6a-6b-n-3′. Alignments of the genome sequence of IBV Beijing isolate with those of two AIBV strains and one SARS coronavirus were performed respectively. The genome sequence of IBV Beijing isolate compared with that of the IBV strain LX4 (uncompleted, 19440 bp in size) was 91.2% similarity. However, the full-length genome sequence of IBV Beijing isolate was 85.2% identity to that of IBV Strain Beaudette, and was only 50.8% homology to that of SARS coronavirus. The results showed that the genome of IBV has remarkable variation. And IBV Beijing isolate is not closely related to SARS coronavirus. Phylogenetic analyses based on the whole genome sequence, S protein, M protein and N protein, also showed that AIBV Bering isolate is lone virus in group Ⅲ and is distant from SARS coronavirus. In conclusion, this study will contribute to the studies of diagnosis and diseases control on IBV in China. 相似文献
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GAO Lei * QI Ji * WEI Haibin * SUN Yigang & HAO Bailin . Institute of Theoretical Physics Chinese Academy of Sciences Bei-jing China . T-Life Research Center Fudan University Shanghai China . Graduate School Zhejiang University Hangzhou China . Hangzhou Branch Beijing Genomics Institute Chinese Academy of Sciences Hangzhou China Correspondence should be addressed to Hao Baibin 《科学通报(英文版)》2003,48(12):1170-1174
The outbreak of SARS sets an urgent task to reveal the origin of human SARS-CoV, i.e. its relation to other known species of coronavirus, and to trace the genetic variation in the spreading process of SARS. Partial answer to the problem may be obtained from phylogenetic analy-sis of available genomes. We call a phylogenetic tree of different species of coronavirus including the human SARS-Cov a CoV Tree and that of different isolates of SARS-CoV a SARS Tree. CoV trees have been c… 相似文献
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20世纪60年代,科学家首次分离出可感染人类的冠状病毒,HCoV-OC43和HCoV-229E早在1966年和1967年已被发现,但直到2003年SARS在全球爆发后冠状病毒才被广泛关注.综述了目前已发现的人感染冠状病毒特点及其与眼部的关系,以期在新型冠状病毒肆虐之际,为眼科一线临床医师筛查、确诊病例提供参考. 相似文献
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JINWeiwu HULiangxiang DUZhenglin GAOQiang GAOHong NINGYe FENGJidong ZHANGJiansan YINWeidong LINing 《科学通报(英文版)》2004,49(17):1824-1827
SARS coronavirus is an RNA virus whose replication is error-prone, which provides possibility for escape of host defenses, and even leads to evolution of new viral strains during the passage or the transmission. Lots of variations have been detected among different SARS-CoV strains. And a study on these variations is helpful for development of efficient vaccine. Moreover, the test of nucleic acid characterization and genetic stability of SARS-CoV is important in the research of inactivated vaccine. The whole genome sequences of two SARS coronavirus strains after passage in Vero cell culture were determined and were compared with those of early passages, respectively. Results showed that both SAPS coronavirus strains have high genetic stability, although nearly 10 generations were passed. Four nucleotide variations were observed between the second passage and the llth passage of Sinol strain for identification of SARS inactivated vaccine. Moreover, only one nucleotide was different between the third passage and the 10th passage of Sino3 strain for SARS inactivated vaccine. Therefore, this study suggested it was possible to develop inactivated vaccine against SARS-CoV in the future. 相似文献
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Introduction In March 2003, a novel coronavirus (CoV) was dis-covered in association with the outbreak of severe acute respiratory syndrome (SARS)[1-3]. The complete genome sequence of several SARS-CoV isolates was soon determined and characterized[4,5]. Comparison of variant SARS-CoV genome sequences has identified certain genetic signatures that can be used to trace sources of infection[6]. Vaccines are now being devel-oped and molecular modeling has suggested that modi-fied rhinovir… 相似文献
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ZHANGZhibin SHENGChengfa MAZufei LIDianmo 《科学通报(英文版)》2004,49(17):1819-1823
The severe acute respiratory syndrome (SARS) caused tremendous damage to many Asia countries, especially China. The transmission process and outbreak pattern of SARS is still not well understood. This study aims to find a simple model to describe the outbreak pattern of SARS cases by using SARS case data commonly released by governments. The outbreak pattern of cumulative SARS cases is expected to be a logistic type because the infection will be slowed down due to the increasing control effort by people and/or due to depletion of susceptible individuals. The increase rate of SARS cases is expected to decrease with the cumulative SARS cases, as described by the traditional logistical model, which is widely used in population dynamic studies. The instantaneous rate of increases were significantly and negatively correlated with the cumulative SARS cases in mainland of China (including Beijing, Hebei, Tianjin, Shanxi,the Autonomous Region of Inner Mongolia) and Singapore. The basic reproduction number R0 in Asia ranged from 2.0 to 5.6 (except for Taiwan, China). The R0 of Hebei and Tianjin were much higher than that of Singapore, Hongkong, Beijing, Shanxi, Inner Mongolia, indicating SARS virus might have originated differently or new mutations occurred during transmission. We demonstrated that the outbreaks of SARS in many regions of Asia were wall described by the logistic model, and the control measures implemented by governments are effective. The maximum instantaneous rate of increase, basic reproductive number, and maximum cumulative SARS cases were also calculated by using the logistic model. 相似文献