共查询到20条相似文献,搜索用时 15 毫秒
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J. E. Décombaz B. Reffet Y. Bloemhard 《Cellular and molecular life sciences : CMLS》1990,46(5):457-458
Summary To test the effect of L-carnitine on glycogen sparing when fat oxidation is increased, 100 mg/kg/d were given to rats orally for 3 days, resulting in 1.8-fold higher muscle carnitine levels. Even when FFA were raised by heparin-stimulated lipolysis, the rate of glycogen degradation was not reduced during exercise. 相似文献
3.
L. F. Panchenko S. V. Pirozhkov S. V. Popova V. D. Antonenkov 《Cellular and molecular life sciences : CMLS》1987,43(5):580-581
Summary Chronic ethanol administration was shown to increase catalase and acyl-CoA oxidase activities in rat myocardium but did not alter the activity of liver peroxisomal enzymes. As a result of alcohol consumption a 2–3-fold increase in the level of lipid peroxidation was observed in the heart tissue while in the liver the induction was much less pronounced. 相似文献
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A. Deshmukh F. Salehzadeh S. Metayer-Coustard R. Fahlman K. S. Nair L. Al-Khalili 《Cellular and molecular life sciences : CMLS》2009,66(8):1457-1466
Excessive nutrients, especially amino acids, impair insulin action on glucose metabolism in skeletal muscle. We tested the
hypothesis that the branched-chain amino acid leucine reduces acute insulin action in primary myotubes via a negative feedback mechanism involving ribosomal protein S6 kinase 1 (S6K1). The effect of S6K1 on glucose metabolism was
determined by applying RNA interference (siRNA). Leucine (5 mM) reduced glucose uptake and incorporation to glycogen by 13%
and 22%, respectively, compared to the scramble siRNA-transfected control at the basal level. Leucine also reduced insulin-stimulated
Akt phosphorylation, glucose uptake and glucose incorporation to glycogen (39%, 39% and 37%, respectively), and this reduction
was restored after S6K1 silencing. Depletion of S6K1 enhanced basal glucose utilization and protected against the development
of impaired insulin action, in response to excessive leucine. In conclusion, S6K1 plays an important role in the regulation
of insulin action on glucose metabolism in skeletal muscle.
Received 22 December 2008; received after revision 19 February 2009; accepted 23 February 2009 相似文献
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S. C. Dogra K. L. Khanduja R. R. Sharma 《Cellular and molecular life sciences : CMLS》1982,38(8):903-904
Summary Vitamin A deficiency reduces the content of glutathione in liver and lung. Also, glutathione S-transferase activity is decreased significantly in the lung, whereas its activity is increased in the liver. 相似文献
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M. -P. Sauviat J. -M. Chesnais J. Diacono J. -F. Biard J. -F. Verbist 《Cellular and molecular life sciences : CMLS》1994,50(10):926-930
Bistramide A, a new toxin isolated from the UrochordateLissoclinum bistratum Sluiter, was applied to rat auricular heart muscle bundles. At a stimulation frequency of 0.2 Hz, the toxin induces a dose-dependent reduction of the stimulated twitch tension force; it decreases
and shortens the duration of the plateau and the slow repolarizing phase of the action potential. In the control solution, switching from a stimulation frequency of 0.2 Hz to 1 Hz decreases the force with which a positive potentiation develops either at a maintained high frequency or after switching from 1 Hz to 0.2 Hz. Bistramide A reduces both the force evoked at 1 Hz and the potentiation. The data suggest that Bistramide A blocks Na+ conductance; inhibits Ca++ channels in a time-and frequency-dependent manner; reduces Na+–Ca++ exchange activity; but does not modify the ability of the sarcoplasmic reticulum to be refilled although the rate of Ca++ accumulation is decreased. 相似文献
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P. Walter 《Cellular and molecular life sciences : CMLS》1991,47(2):178-181
Summary Some recent evidence on the benefits and hazards of elevated dosages of vitamins is summarized. Special emphasis is given on the safety of vitamins A, D, K1 and B6. Furthermore, the possibly beneficial effects of vitamins for athletic performance as well as the preventive potential of antioxidative vitamins and of carotenoids against cancer are discussed. 相似文献
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É. Rónai L. Mészáros Gy. Benkő I. Horváth 《Cellular and molecular life sciences : CMLS》1984,40(12):1375-1376
Summary Succinate inhibits NADPH-dependent lipid peroxidation of liver mitochondria. This effect of succinate decreased 12 h after whole-body60Co-gamma irradiation, depending on the dose of irradiation. 相似文献
9.
Production of active and passive anaphylactic shock in the WBB6F1 mouse,a mast cell-deficient strain
A. Arimura M. Nagata A. Watanabe K. Nakamura M. Takeuchi M. Harada 《Cellular and molecular life sciences : CMLS》1990,46(7):739-742
Summary The role of mast cells in active and passive anaphylactic shock was examined using the WBB6F1 mouse, a genetically mast cell-deficient strain. Lethal anaphylactic shock occurred at high incidence rates in mice actively sensitized to bovine serum albumin (BSA). The reaction was specific to BSA since the shock could not be elicited by human or guinea pig serum albumin in these animals. Lethal shock could be prevented by CV-3988 but not by cyproheptadine, which suggests that the shock is mediated by PAF but not by histamine and serotonin. Similarly, lethal shock was provoked by homologous antigens in mice which had been passively sensitized with allogeneic anti-benzylpenicilloyl (BPO) IgG1 monoclonal antibody or with allogeneic or xenogeneic anti-BSA antiserum, but not in those sensitized with allogeneic anti-BPO IgE monoclonal antibody. These findings suggest that mast cells are not necessarily required for anaphylactic shock in the mouse. 相似文献
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M. Ochsner 《Cellular and molecular life sciences : CMLS》1996,52(9):856-864
The dose-dependent effect of CGP 45715A on the LTD4-induced Ca2+ response of glomerular mesangial cells has been studied. Our results demonstrate that the LTD4-dependent increase in the cytosolic Ca2+ concentration primarily involves an InsP3-mediated release of Ca2+ from intracellular storage sites and to a minor extent an enhanced influx of Ca2+ through receptor-operated Ca2+ channels located in the plasma membrane. The action of CGP 45715A on the Ca2+ response is an inhibitory one and is convincingly explained by a displacement of LTD4 from its receptor site(s). The contractile effect of LTD4 on pulmonary smooth muscle is proposed to be mainly caused by a receptor-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. 相似文献
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Summary The longitudinal and circular muscle cells of the alimentary canal of the oligochaete wormBranchiura sowerbyi show intercell couplings. These couplings occur between adjoining cells of the same or of the other orientation.We wish to thank Dr S. Kawaguti, Prof. emeritus of Okayama University, for his kind advice. 相似文献
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H. Kohno Y. Hoshino S. Katoh Y. Ohkubo 《Cellular and molecular life sciences : CMLS》1992,48(4):386-388
Transglutaminase (TGase) activity in the cytosol fraction of the mouse liver increased following intraperitoneal injection of retinoic acid. Retinoic acid inhibited the carbon tetrachloride-induced increase in serum alanine transaminase activity. These findings suggest that TGase is involved in the effect of retinoic acid on carbon tetrachloride-induced liver damage. 相似文献
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A. Sahu 《Cellular and molecular life sciences : CMLS》1984,40(11):1285-1287
Summary Female bandicoot rats showing irregular cycles in 12L12D, were exposed to light-darkness cycles of 1L23D, 4L20D and 8L16D. Significant regularization of the estrous cycle was observed in 8L16D with most of the rats exhibiting a regular 3-day cycle and the regularity was further enhanced by all-female grouping (4/cage). 相似文献
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H. Matsuoka K. Yamada K. Atarashi M. Takagi T. Sugimoto 《Cellular and molecular life sciences : CMLS》1990,46(7):726-728
Summary To investigate the roles of adenosine A1 and A2 receptors in the regulation of aldosterone production, we examined the effects of adenosine and adenosine agonists (N6-cyclohexyl adenosine; selective adenosine A1 receptor agonist and 5-N-ethylcarboxamine adenosine; selective adenosine A2 receptor agonist) on aldosterone and cyclic AMP production in rat adrenal capsular cells. Neither adenosine nor 5-N-ethylcarboxamine adenosine caused significant effects on basal aldosterone or cyclic AMP production. Also, adenosine (10–3M) showed no consistent effects on aldosterone and cyclic AMP production induced by ACTH. On the other hand, N6-cyclohexyl adenosine exhibited a significant inhibition of basal aldosterone and cyclic AMP production at doses of 10–4 M and 10–3 M; furthermore, 10–3 M N6-cyclohexyl adenosine inhibited aldosterone and cyclic AMP production stimulated by ACTH. These results suggest that adenosine A1 receptors are coupled to and inhibit adenylate cyclase and may be involved in the inhibition of aldosterone production. 相似文献
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Summary Exchange-transfusion to hematocrit 20 with isotonic perfluorochemical (PFC) emulsions containing 3% hydroxyethylstarch (HES) in rats breathing 100% oxygen produced significant reductions of hepatic PO2 and blood flow in comparison to rats hemodiluted with isotonic 3% or 6% HES solution. The results indicate that PFC and/or emulsifiers were associated with adverse effects on liver blood supply.This work was supported by a grant from the Kentucky Affiliate of the American Heart Association. 相似文献
16.
K. Ogawa T. Ito M. Ban M. Motizuki T. Satake 《Cellular and molecular life sciences : CMLS》1986,42(9):1014-1015
Summary The effects of kallidinogenase on urinary kallikrein excretion, plasma immunoreactive prostanoids and platelet aggregation were investigated in patients with essential hypertension. Urinary kallikrein excretion and plasma 6-keto PGF1 concentration were significantly decreased in these patients. Significant decreases in blood pressure, as well as significant increases of urinary kallikrein excretion and plasma 6-keto PGF1 concentration after kallidinogenase administration were also observed. 相似文献
17.
N. S. Yamamoto A. M. Kelmer Bracht E. L. Ishii F. S. Kemmelmeier M. Alvarez A. Bracht 《Cellular and molecular life sciences : CMLS》1985,41(1):55-57
Summary The effect of several natural products ofStevia rebaudiana on glucose production and oxygen uptake in rat renal cortical tubules was investigated. Steviol, isosteviol and glucosilsteviol decreased glucose production and inhibited oxygen uptake. The sweet principle stevioside, and steviolbioside, however, were without effect on gluconeogenesis and oxygen uptake. 相似文献
18.
The purpose of the present study was to determine the relationship between concentration of Zn, Cu and Fe, and the catalase, glutathione peroxidase and superoxide dismutase activities in the heart and liver of newborn rats whose dams were fed a diet supplemented with caffeine. Heart Zn levels of the 22- and 30-day-old rats of the caffeine group showed a decrease, whereas liver Zn levels showed an increase compared to the control. Cu levels in the liver at day 22 in the caffeine group were less than in the control. Cu- and Zn-containing superoxide dismutase activities showed an increase in the hearts of the caffeine group compared to the control. The activity of catalase and glutathion peroxidase showed no difference in the heart and liver between the groups. The present study suggests the possible involvement of superoxide dismutase enzyme in the impairment of heart formation as a result of chronic caffeine intake in the early growing period. 相似文献
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The effect of dried oyster mushroom (Pleurotus ostreatus) on cholesterol (C) content in serum, in lipoproteins and in liver, and on the activity of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase in liver microsomes, was studied in male rats (strain Wistar, initial body weight 75 g) fed on low-cholesterol (9 mg/100 g) and high-cholesterol (0.3%) diets. Addition of 5% oyster mushroom to both diets reduced significantly the C-content in serum (by 30%), in very-low- and low-density lipoproteins (in a 11 ratio to the decrease of total serum C) and in liver (by 50%), as well as the activity of HMG-CoA reductase (by more than 30%). 相似文献