共查询到20条相似文献,搜索用时 31 毫秒
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I. Palik P. Hadházy K. Magyar B. Malomvölgyi M. Wagner G. Pogátsa 《Cellular and molecular life sciences : CMLS》1981,37(8):863-864
Summary Contractile responses of isolated coronary arteries from healthy and alloxan-diabetic dogs to prostaglandin F2 were enhanced by indomethacin and inhibited by prostaglandin I2. The potentiation by indomethacin was more prominent in diabetic vessels than in normal arteries. 相似文献
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Summary 2-Halogeno- and 2-methyl-ethanols inhibit-chymotrypsin in the order of their substituted groups: [1] tri>di->mono-, [2] Br->Cl->CH3->F-. The inhibition by the halogeno-ethanols is mediated differently from that by the methyl-ethanols, ethanol, and urea. 相似文献
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I. Bryman A. Norström B. Lindblom 《Cellular and molecular life sciences : CMLS》1985,41(11):1446-1447
Summary Cervical specimens were obtained by needle biopsy in connection with caesarean section at term pregnancy. The preparations were superfused in an organ chamber and contractions were registered isometrically. Prostaglandin (PG) E2 and F2 inhibited spontaneous contractions. The stimulatory action of noradrenaline was not influenced by PGF2 but was reduced by PGE2 whereas both PGs abolished the excitatory effect of oxytocin. 相似文献
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Maarten Moes Johannes Boonstra Elsa Regan-Klapisz 《Cellular and molecular life sciences : CMLS》2010,67(9):1547-1557
Actin-directed processes such as membrane ruffling and cell migration are regulated by specific signal transduction pathways
that become activated by growth factor receptors. The same signaling pathways that lead to modifications in actin dynamics
also activate cPLA2α. Moreover, arachidonic acid, the product of cPLA2α activity, is involved in regulation of actin dynamics. Therefore, it was investigated whether cPLA2α plays a role in actin dynamics, more specifically during growth factor-induced membrane ruffling and cell migration. Upon
stimulation of ruffling and cell migration by growth factors, endogenous cPLA2α and its active phosphorylated form were shown to relocate at protrusions of the cell membrane involved in actin and membrane
dynamics. Inhibition of cPLA2α activity with specific inhibitors blocked growth factor-induced membrane and actin dynamics, suggesting an important role
for cPLA2α in these processes. 相似文献
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D. J. McComb N. Ryan E. Horvath K. Kovacs I. Domokos F. A. Laszlo 《Cellular and molecular life sciences : CMLS》1979,35(10):1409-1410
Summary Following 2 weeks of administration of 2-bromo--ergocryptine, a marked decrease was observed in prolactin immunoreactivity of the grafted pituitaries, whereas no reduction was noted in the intrasellar pituitaries. No evidence of crinophagy was revealed by electron microscopy in prolactin cells of 2-bromo--ergocryptine-treated rats.Acknowledgments. This work was supported in part by the Medical Research Council of Canada (grant MA-6349). The excellent technical assistance of Mrs Cynthia Edwards and secretarial help of Mrs Wanda Wlodarski are gratefully acknowledged. 相似文献
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A. G. Bosanquet A. M. Chandler A. H. Gordon 《Cellular and molecular life sciences : CMLS》1976,32(10):1348-1349
Summary The effects of injury on the concentration of 1-macroglobulin and 2-macroglobulin in the plasmas of male and female rats has been investigated. At 5 days after injury to the male rats the 1-macroglobulin concentration increased to 131% of its preinjury value. The 2-macroglobulin concentration increased more rapidly to a maximum of 86 times its initial value. In the female rats 2-macroglobulin increased only slightly and 1-macroglobulin not at all. 相似文献
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B. J. Clarris 《Cellular and molecular life sciences : CMLS》1982,38(3):350-351
Summary In medium supplemented with serum, PGE1 and PGE2 were equally potent in inducing cells with a fenestrated appearance, whereas PGF2 was comparatively ineffective. In BSA without serum the effects were more persistent and characterized by a high proportion of astrocyte-like cells. The effects were reversed upon removal of the prostaglandins.This work was supported by the National Health and Medical Research Council of Australia. 相似文献
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C. H. W. Horne A. W. Thomson C. B. J. Hunter V. van Heyningen D. L. Deane C. M. Steel 《Cellular and molecular life sciences : CMLS》1979,35(3):411-412
Summary 2-PAG is present on the surface of mononuclear blood leucocytes and can be demonstrated predominantly on B-lymphocytes and monocytes. Pretreatment of cells with antibody to 2-PAG leads to a marked reduction in Fc-rosette formation. Competitive blocking experiments with specific antisera reveal a particularly close asociation between 2-PAG and MLR (mixed leucocyte reaction) determinants on the cell surface. These findings suggest one mechanism whereby 2-PAG may modify cell-mediated immune responses. 相似文献
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Ina M. Wittko-Schneider Fabian T. Schneider Karl H. Plate 《Cellular and molecular life sciences : CMLS》2013,70(10):1705-1725
Vascular endothelial growth factors (VEGFs), initially thought to act specifically on the vascular system, exert trophic effects on neural cells during development and adulthood. Therefore, the VEGF system serves as a promising therapeutic target for brain pathologies, but its simultaneous action on vascular cells paves the way for harmful side effects. To circumvent these deleterious effects, many studies have aimed to clarify whether VEGFs directly affect neural cells or if the effects are mediated secondarily via other cell types, like vascular cells. A great number of reports have shown the expression and function of VEGF receptors (VEGFRs), mainly VEGFR-1 and -2, in neural cells, where VEGFR-2 has been described as the major mediator of VEGF-A signals. This review aims to summarize and compare the divergent roles of VEGFR-1 and -2 during CNS development and homeostasis. 相似文献
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Apoptosis is a fundamental process for metazoan development. It is also relevant to the pathophysiology of immune diseases and cancers and to the outcome of cancer chemotherapies, as well as being a target for cancer therapies. Apoptosis involves intrinsic pathways typically initiated by DNA damaging agents and engaging mitochondria, and extrinsic pathways typically initiated by “death receptors” and their ligands TRAIL and TNF at the cell surface. Recently, we discovered the apoptotic ring, which microscopically looks like a nuclear annular staining early in apoptosis. This ring is, in three-dimensional space, a thick intranuclear shell consisting of epigenetic modifications including histone H2AX and DNA damage response (DDR) proteins. It excludes the DNA repair factors usually associated with γ-H2AX in the DDR nuclear foci. Here, we summarize our knowledge of the apoptotic ring, and discuss its biological and pathophysiological relevance, as well as its value as a potential pharmacodynamic biomarker for anticancer therapies. 相似文献
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Lan Shen Xuewu Liu Wugang Hou Guodong Yang Yousheng Wu Rui Zhang Xia Li Honglei Che Zifan Lu Yuanqiang Zhang Xinping Liu Libo Yao 《Cellular and molecular life sciences : CMLS》2010,67(8):1371-1381
The N-myc downstream-regulated gene 2 (NDRG2) is involved in cell differentiation and apoptosis, but its function in the pancreas remains to be established. Herein we examine the expression and function of NDRG2 in the endocrine pancreas. NDRG2 immunoreactivity was localized mainly in the cytoplasm of pancreatic β cells. When β-TC3 cells were exposed chronically to high levels of free fatty acid (FFA), cell viability was impaired, and Akt and NDRG2 phosphorylation were reduced. NDRG2 is a potential substrate of protein kinase Akt. Overexpression of constitutively active Akt enhanced NDRG2 phosphorylation and abolished the apoptosis induced by FFA in β-TC3 cells, whereas NDRG2 knock-down attenuated Akt-mediated protection of β cells against fatty acid-triggered apoptosis. Collectively, these data indicate that NDRG2 acts as a key molecule in pancreatic β cells and is involved in the Akt-mediated protection of β cells against lipotoxicity. 相似文献
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Noel A. Warren Georgios Voloudakis Yonejung Yoon Nikolaos K. Robakis Anastasios Georgakopoulos 《Cellular and molecular life sciences : CMLS》2018,75(15):2813-2826
Presenilin-1 (PS1) gene encodes the catalytic component of γ-secretase, which proteolytically processes several type I transmembrane proteins. We here present evidence that the cytosolic peptide efnB2/CTF2 produced by the PS1/γ-secretase cleavage of efnB2 ligand promotes EphB4 receptor-dependent angiogenesis in vitro. EfnB2/CTF2 increases endothelial cell sprouting and tube formation, stimulates the formation of angiogenic complexes that include VE-cadherin, Raf-1 and Rok-α, and increases MLC2 phosphorylation. These functions are mediated by the PDZ-binding domain of efnB2. Acute downregulation of PS1 or inhibition of γ-secretase inhibits the angiogenic functions of EphB4 while absence of PS1 decreases the VE-cadherin angiogenic complexes of mouse brain. Our data reveal a mechanism by which PS1/γ-secretase regulates efnB2/EphB4 mediated angiogenesis. 相似文献
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Mohammad Salem Jakob Benedict Seidelin Gerhard Rogler Ole Haagen Nielsen 《Cellular and molecular life sciences : CMLS》2013,70(18):3391-3404
Crohn’s disease (CD) is one of main disease entities under the umbrella term chronic inflammatory bowel disease. The etiology of CD involves alterations in genetic, microbiological, and immunological factors. This review is devoted to the role of the bacterial wall compound muramyl dipeptide (MDP) for the activation of inflammatory pathways involved in the pathogenesis of CD. The importance of this molecule is underscored by the fact that (1) MDP, which is found in most Gram-negative and -positive bacteria, is able to trigger several immunological responses in the intestinal system, and (2) that alterations in several mediators of the MDP response including—but not restricted to—nucleotide oligomerization domain 2 (NOD2) are associated with CD. The normalization of MDP signaling is one of several important factors that influence the intestinal inflammatory response, a fact which emphasizes the pathogenic importance of MDP signaling for the pathogenesis of CD. The important aspects of NOD2 and non-NOD2 mediated effects of MDP for the development of CD are highlighted, as well as how alterations in these pathways might translate into the development of new therapeutic strategies. 相似文献