Effect of methyl ester of aristolic acid fromAristolochia indica Linn. on fertility of female mice

Summary Methyl ester of aristolic acid, a pure compound isolated from the roots ofAristolochia indica (Linn.), was found to exert 100% abortifacient activity at a single oral dose of 60 mg/kg b. wt when administered on 6th or 7th day of pregnancy; 20 and 25% abortifacient effect were observed at the same dose on day 10 and 12, respectively.The authors wish to thank Dr S.C. Pakrashi and his associate Mr P.P. Ghosh Dastidar for the compound. Thanks are also due to the Director General of Indian Council of Medical Research for granting a fellowship to one of them (C.S.).     

Effect of the extracts fromAristolochia indica Linn. on interception in female mice

Summary The crude petroleum ether, chloroform and alcoholic extracts of the roots ofAristolochia indica (Linn.) showed 100% interceptive activity in mature female mice at the single dose of 100 mg/kg body wt. The follow-up studies with the chloroform extract showed the most significant effect in the basic part and two acidic fractions at the single dose levels of 50 mg/kg body wt. No toxic effect was observed at the dose levels used.The authors are thankful to Mr.P. P. Ghosh Dastidar, Medicinal Chemistry Division for the plant extracts. Thanks are also due to Indian Council of Medical Research and Council of Scientific and Industrial Research for granting scholarships to two of them (B.C. and A.D.) and to Prof.R. N. Chakravarti, Director of the Institute for encouragement.     

Effect of a sesquiterpene fromAristolochia indica Linn. on fertility in female mice

Summary A sesquiterpene isolated from the roots ofAristolochia indica (Linn.) was found to exert 100% interceptive activity and 91.7% anti-implantation activity in mice at a single oral dose of 100mg/kg b. wt. No toxic effect was found at the dose levels used.The authors wish to thank Dr S. C. Pakrashi and his associate Mr P. P. Ghosh Dastidar of Medicinal Chemistry Department for isolating the compound for this study. Thanks are also due to Director-General of Indian Council of Medical Research for granting a Junior Research Fellowship to C.S.     

Effect of the extracts from Aristolochia indica Linn. on interception in female mice.

The crude petroleum ether, chloroform and alcoholic extracts from the roots of Aristolochia indica (Linn.) showed 100% interceptive activity in mature female mice at the single dose of 100 mg/kg body wt. The follow-up studies with the chloroform extract showed the most significant effect in the basic part and two acidic fractions at the single dose levels of 50 mg/kg body wt. No toxic effect was observed at the dose levels used.     

Antifertility activity of dihydroelatericin a in the female mouse

Résumé Dihydroelatericine A administré par voie buccale à des souris femelles au moins pendant deux semaines, empêche la fertilisation. L'éxamen histologique des ovaires démontre que la substance prévient l'ovulation.     

Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit

Hyperthermia induced by arachidonic acid in rabbit was attenuated by phenoxybenzamine, cyproheptadine and indomethacin. The reduction in arachidonic acid hyperthermia, after 6-OH-DA and the failure of PCPA to reduce this rise, indicates the involvement of noradrenaline in arachidonic acid hyperthermia.     

Central effect of 5,8,11,14-eicosatetraenoic acid (arachidonic acid) on the temperature in the conscious rabbit

Summary Hyperthermia induced by arachidonic acid in rabbit was attenuated by phenoxybenzamine, cyproheptadine and indomethacin. The reduction in arachidonic acid hyperthermia, after 6-OH-DA and the failure of PCPA to reduce this rise, indicates the involvement of noradrenaline in arachidonic acid hyperthermia.     

Hepatic acid hydrolases of albino rats, Mastomys natalensis and albino mice during Plasmodium berghei infection

Changes in liver acid hydrolase activities during the infection of albino rats, Mastomys or mice with Plasmodium berghei are described. B-Glucosidase, B-galactosidase and N-acetyl-B-D-glucosaminidase exhibited widely different responses with acid phosphatase and cathepsin-B the least responsive and are likely to be causally related to immunity of animals.     

Raffinose inStomoxys calcitrans Linn. (diptera,cyclorrhaphpa: Muscidae)

Résumé La raffinose a été découverte pour la première fois dans l'insecteS. calcitrans, une mouche suceuse de sang. Le sucre est présent dans les ufs fraîchement pondus, dans les larves au troisième stage, dans les pupes blanches et dans les toutes jeunes mouches. On a aussi discuté le róle probable de ce sucre.     

Lysozyme activity in female genital tissues of normal and genetically lysozyme-deficient rabbits

The internal genitalia of female normal rabbits and mutant lysozyme-deficient rabbits, which lack genetically the leukocytic isozyme of lysozyme, were assayed for lysozyme activity. The ovaries, uteri, and vaginas of the lysozyme-deficient rabbits had less than 20% of the lysozyme activity of normals. The oviducts, and in particular the caudal portions of the oviducts, had lysozyme activities up to 71% of the levels in normals. These observations suggest that the lysozymes of oviduct and leukocytes of rabbits are under the control of different genes.     

Lysozyme activity in female genital tissues of normal and genetically lysozyme-deficient rabbits

Summary The internal genitalia of female normal rabbits and mutant lysozyme-deficient rabbits, which lack genetically the leukocytic isozyme of lysozyme, were assayed for lysozyme activity. The ovaries, uteri, and vaginas of the lysozyme-deficient rabbits had less than 20% of the lysozyme activity of normals. The oviducts, and in particular the caudal portions of the oviducts, had lysozyme activities up to 71% of the levels in normal. These observations suggest that the lysozymes of oviduct and leukocytes of rabbits are under the control of different genes.Supported in part by grants RR00515, RR05465, K04-RR00003, and T32-GM07160 from the National Institutes of Health. We acknowledge the excellent technical assistance of LeeAndra Froseth.     

The effect of thyroid gland on 5-Hydroxy-tryptamine (5-HT) level of brain stem and blood in rabbits

Zusammenfassung An Kaninchen wurde die Wirkung von Schilddrüsenfütterung und Thyreoidektomie auf das 5-HT-Niveau im Hirnstamm und Blut untersucht. In hyperthyreotischem Zustand ist der 5-HT-Spiegel im Blut und im Hirnstamm erhöht, bei Athyreose ist er verringert. Der Schilddrüseneffekt wird in der Veränderung des Tryptophan- Stoffwechsels über das zentrale Nerven-system gesehen.     

On the hepato-protective effect of selenium in carbon tetrachloride poisoning in albino rats

Résumé Les auteurs ont étudié l'effet hépatoprotecteur du sélénite de sodium administré en doses de 1 /100 g du poids corporel, avant, pendant et après l'intoxication de rats avec du tétrachloride de carbone. Ils en ont conclu que, suivant un critère anatomo-pathologique, l'effet antitoxique du sélénite de sodium est de protéger le parenchime hépatique contre l'action du tétrachloride de carbone.