环核苷酸检测法研究中药归经

中药归经理论的研究对解释中药作用的趋向性具有重要的意义,本文简要介绍了中药归经及其现代研究方法,并总结归纳了环核苷酸检测法研究中药归经的研究进展,为进一步完善归经理论的研究提供了一定的参考．     

钾元素在常用跌打损伤类中药治疗运动损伤中的作用

采用火焰分光光度计测定法对常用跌打损伤中药中的钾元素进行测定,并对中药按不同功能主治和不同首归归经分类进行分析,结果得出:钾元素在接骨续筋、清热解毒、活血化瘀类和首归肾经、首归肝经、首归心经类中药中的含量较高,钾元素在常用跌打损伤类中药治疗运动损伤中有治疗作用.     

神经免疫内分泌网络学说在中医研究中的应用

目前,神经—免疫—内分泌网络(NEI网络)的研究已成为国内外学者研究的热点.国内中西医结合学者发现NEI网络是中西医理论体系相互整合的重要手段和方法.本文简要介绍了"神经—免疫—内分泌网络"学说,并以中医脏腑、中药归经理论的实验研究、经络与针刺为例综述了神经免疫内分泌网络学说在中医研究中的应用.     

中药代谢化学研究方法

随着中药现代化研究的新进展,越来越多的研究表明许多中药中的化学成分只有经代谢后才具有生物活性.因此,对中药单体成分及复方的代谢化学研究引起了越来越多的研究人员的重视.近年来对代谢化学的研究逐步深入,中药代谢化学研究方法也随之深入,为中药化学成分及其产生生物活性的有效成分的研究提供依据.概述了有关代谢化学研究方法的新进展,为中药新药研究、中药药效物质研究、以中药有效成分为先导的药物研究及中药质量评价提供了依据.     

中药化学成分肠道代谢的研究

中药的化学成分复杂,经肠道代谢后,最终发挥药效的是中药中的化学成分,亦或是中药成分的代谢物,也有可能是口服中药后机体发生应激反应产生的物质.近年来,许多科研人员通过研究中药的化学成分,从而进一步揭示其药效物质的归属问题,目前已取得了很大的成效.下面就几种中药化学成分的肠道代谢研究进行简单的综述.     

经络辨治甲状腺良性结节的数据挖掘分析

目的:探讨运用经络理论在甲状腺良性结节临床辨证论治中的规律.方法:检索1950-2020年在中国知网(CNKI)、万方数据知识服务平台、维普等数据库中关于中医药治疗甲状腺良性结节的文献,提取文献纳入的中药、取穴处方等数据,对高频药物归经、高频穴位、经络进行频次分析、关联分析及聚类分析,并对所涉及的经络进行网络可视化分析...     

基于数据挖掘和网络药理学探讨脑血栓用药规律及其机理

目的：挖掘中药治疗脑血栓的用药规律并分析核心药对的作用机制.方法：搜索维普、万方、知网等数据库,筛选脑血栓治疗方剂并建立数据库,借助IBM SPSS Statistics 20进行用药频次分析和因子分析,运用Clementine12.0挖掘中药之间的关联规则及核心药对,利用TCMSP、STRING、DAVID数据库和Cytoscape软件等分析核心药对抗脑血栓的成分、靶点及通路;通过Metascape数据库和分子对接技术进行靶点模块分析及对接验证.结果：纳入方剂181首,涉及的260味中药以温性、寒性以及苦味、甘味为主,多归肝经,因子分析中提取5个公因子.关联规则显示桃仁-红花的置信度最高,其19个活性成分对应127个靶基因,其中IL6、MAPK1、JUN、TP53等是关键靶点.关键靶点参与RNA聚合酶II启动子、DNA转录的正调控等生物过程;调控Toll样受体、MAPK、ErbB等信号通路;与关键活性成分槲皮素、木犀草素的亲和力高.结论：中药治疗脑血栓多以甘温、苦寒且归肝经中药为主,组方常由补阳还五汤、六君子汤、芍药甘草汤等加减化裁而成,桃仁-红花是其核心药对.     

简析数学思想在2000年全国高试数学中的应用

数学思想 ,是人们对数学本质认识的客观反映 ,是数学思维的结晶 ,它直接支配着数学的实践 ,是解决问题的灵魂 ,重视对数学思想应用的考查 ,既是高考命题的一贯原则 ,又是培养科学思维方式、促进创新教育提高的需要 .仔细研究 2 0 0 0年全国高考数学试题 (理 ) ,不难发现基本数学思想的应用已成为的热点 ,应引起我们重视和研究 .下面结合实例 ,予以浅析 .　　 1　考查化归转化思想应用化归转化思想就是通过数学内部的联系和矛盾运动 ,运用有关的数学方法 ,将待解决的问题逐步转化为熟悉的或已经解决了的问题去解决 .例 1　设函数 f ( x) =x2 …     

超临界CO2萃取岷县当归挥发油的成分研究--色质联用法鉴定岷县当归挥发油的成分

不同于以往的水蒸气蒸馏,使用超临界CO2萃取技术萃取岷县当归(AngelicaSinensis(o liv.)Diels)根部(中药药效部分)的挥发油,并通过气相色谱和色质联用等分析手段对其成分进行了研究.结果共分离鉴定出41种化合物,其中主要成分藁本内酯、正丁基芙内酯、亚油酸含量分别为48.16%、12.15%、9.10%.另有α 喜瑞文烯、β 雪松烯等10种化合物为首次自岷县当归油中分离得到.同时也通过对照实验比较了超临界CO2与水蒸气蒸馏两种挥发油提取方法的差别..     

对体育与健康的理性认识

通过对体育思想历史演变的回顾与研究，揭示了体育之增强体能、增强健康的最本质功能，继而提出了追求体育的健康目标，既是对人类自身的尊重，也是现代体育思想的基本理念，更是体育的必然归缩。     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

An Analysis of Catherine＇s Character——Wuthering Heights

Wuthering Heights, Emily Bronte＇s only novel, was published in December of 1847 under the pseudonym Ellis Bell. The book did not gain immediate success, but it is now thought one of the finest novels in the English language. Catherine is the key character of this masterpiece, because everybody and everything center on her though she had a short life. We can understand this masterpiece better if we know Catherine well.     

Lower Paleozoic oil relationships within Williston Basin, Canada

The Williston Basin is a significant petroleum province, containing oil production zones that include the Middle Cambrian to Lower Ordovician, Upper Ordovician, Middle Devonian, Upper Devonian and Mississippian and within the Jurassic and Cretaceous. The oils of the Williston Basin exhibit a wide range of geochemical characteristics defined as "oil families", although the geochemical signature of the Cambrian Deadwood Formation and Lower Ordovician Winnipeg reservoired oils does not match any "oil family". Despite their close stratigraphic proximity, it is evident that the oils of the Lower Palaeozoic within the Williston Basin are distinct. This suggests the presence of a new "oil family" within the Williston Basin. Diagnostic geochemical signatures occur in the gasoline range chromatograms, within saturate fraction gas chromatograms and biomarker fingerprints. However, some of the established criteria and cross-plots that are currently used to segregate oils into distinct genetic families within the basin do not always meet with success, particularly when applied to the Lower Palaeozoic oils of the Deadwood and Winnipeg Formation.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Design and analysis of generic LBS application developing platform

Location based services is promising due to its novel working style and contents.A software platform is proposed to provide application programs of typical location based services and support new applications developing efficiently. The analysis shows that this scheme is easy implemented, low cost and adapt to all kinds of mobile nework system.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that