Contribution to the method for approximation of X-ray diffraction line profile

. , . .     

Hemodynamic changes in rats without adrenal medula submitted to hypovolemic shock

Resumen La extirpacion de la medula suprarrenal no provoca alteraciones de la hemodinamia en ratas estudiadas en condiciones basales, mientras que durante el shock hipovolemico las ratas meduloprivas presentan un volumen minuto cardiaco menor, y un aumento de la presion arterial media y de la resistencia periferica total, en relacion a los testigos normales sometidos al mismo tipo de shock.

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This work has been partially supported with a grant from the Consejo Nacional de Investigaciones Cientificas y Técnicas. The isotopes were obtained through the Comisión Nacional de Energía Atomica.

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Established Investigator. Carrera del Investigador Científico del Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina.     

Über das Vorkommen verschieden substituierter Chalkone während der Mikrosporogenese beiTulipa

Summary During the development of anthers inTulipa cv. Apeldoorn the following chalcones were isolated: 2, 3, 4, 4, 6-pentahydroxychalcone as the main component and 2, 4, 4, 6-tetrahydroxy-3-methoxychalcone as well as 2, 4, 4, 6-tetrahydroxychalcone in a very small amount.

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Die Untersuchungen wurden mit Mitteln der Deutschen Forschungsgemeinschaft unterstützt.     

Wirkung von 6β-Methoxy-9β,10α-pregna-4,6-dien-3,20-dion

Summary 6-Methoxy-9,10 -pregna-4,6-diene-3,20-dione inhibites the ⁴-3-oxosteroid-5-reduction in microsomes and the ⁴-3-oxosteroid-5-reduction in the soluble fraction of male rat liver. The 3- and 3-hydroxysteroid dehydrogenase are not inhibited by this substance.

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Diese Arbeit wurde von der Firma Hoffmann-La Roche, Basel, unterstützt.     

Reactive synthesis of DNA and mitotic division in atrial heart muscle cells following ventricle infarction

/- 5 - / . , .     

The molecular structure of the benzilic acid rearrangement product of 3α, 17β-diacetoxy-11-hydroxy-12-oxo-5β-androst-9(11)-ene

Zusammenfassung Die Struktur desp-Brombenzoates des Benzilsäureumlagerungsproduktes von 3, 17-Diacetoxy-11-hydroxy-12-oxo-5-9(11)-androsten wurde durch dreidimensionale Röntgenstrukturanalyse eines Einkristalls als 3-p-Brombenzoat des 11-Carboxy-3, 11, 17-trihydroxy-13-C-nor-5-androstan 11a, 17-Laktons erkannt.     

Chromosomes and giemsa-bands of the Idaho spotted ground squirrel,Spermophilus brunneus (Howell)

-Spermophilus brunneus . , 13 18 ,S. brunneus S. townsendii mollis (2n=38) , , ; ;S. brunneus . S. brunneus , Spermophilus.

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Supported by National Science Foundation Grants No. GB32114X and No. GB 29131X, and the Sprague Foundation. We thankD. Pozin for technical assistance.     

The metabolism of hexamethylphosphoramide and hexamethylthiophosphoramide

Résumé L'hexaméthylphosphoramide (I), un agent antispermatogénique efficient pour rongeurs, est dégradé par une succession de déméthylations (I II III IV) pour inactifs metabolites. Le thio-analogue (V), à moins qu'il soit metabolisé (I), est inactif au cours d'un cheminement alternatif (V VI II).

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This work was supported by grants from the Ford Foundation and the Wellcome Trust.     

Thymus stimulation and cancer prophylaxis byViscum proteins

Zusammenfassung Die cancerostatischen Viscum-Proteine induzieren im Tierversuch mit geringsten Dosen eine Proliferation des Thymus und verhindern prophylaktisch das Angehen von Tumoren. Höhere Dosen zerstören dagegen den Immunapparat durch Überbeanspruchung und die Tumorhemmung bleibt aus.

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We are indebted to the Deutsche Forschungsgemeinschaft for financial support (M. St.) and for granting a Forschungsfreijahr (F. V.).     

Conversion of γ-hydroxybutyrate to γ-aminobutyrate by mouse brain in vivo

Zusammenfassung -Hydroxybutyrat wird im Maushirn in-Aminobutyrat und in verschiedene -Aminosäuren umgewandelt.

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Supported by the Medical Research Council of Canada.     

Hemmung der Phosphodiesterase aus Rattenherzen durch Intensain

Summary Intensain causes in vitro a significant and apparently competitive inhibition of phosphodiesterase, which transforms the 3,5-AMP to 5-AMP. These results explain some intensain effects, especially the period of latency to reach the maximum effect, the inotropic action and its reaction under the influence of-blocking and-stimulating agents^10–13.

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3-(-Diäthylamino-äthyl)-4-methyl-7-carbäthoxy-methoxy-2-oxo-(1,2-chromen), Carbochromen.     

G-band patterns as chromosomal markers,and the interpretation of chromosomal evolution in wild sheep (Ovis)

- . Ovis musimon (2n=54) O. orientalis (2n=54) - - -O. canadensis mexicana (2n=54) O. musimon x O. canadensis ₁₂ - . ₂ 27 . - .

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Supported by National Science Foundation Grant no. GB 32114X and the Sprague Foundation. We thank Dr. T. C. Hsu for assistance in making the chromosome preparations and for advice and encouragement. The Trustees of the Rachelwood Wildlife Research Preserve generously allowed the biopsy of specimens of their custody. Mr.Arthur Popham kindly provided the specimens from Iran while Dr.R. M. Robinson obtained biopsies from the desert sheep.     

Il punto nella terminologia matematica greca

Summary In this note we claim that the two words and , which were used in Greece to indicate the geometrical point, had both been introduced in the scientific language in the first half of the IV^th century B.C., and that they became popular independently of each other in two different cultural circles, those of philosophy and of mathematics, respectively.We propose therefore, in contrast to a conjecture by Heiberg, a new explanation for the predominance of during the golden age of Greek mathematics and for the resurgence of during the period of decadence.

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Memoria presentata da A. Seidenberg     

The effect of chloramphenicol analogs on protein biosynthesis in a cell-freeEscherichia coli B system

a aaa a aa aa a a E. coli aa, a aa aa a , a a aa - a .

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Laboratory of Biological Investigations.

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Laboratory for Chemistry of Antibiotics.     

Isolierung von 4α-methyl-5α-stigmasta-7,24(28)-dien-3β-ol ausSolanum tuberosum sowie über die Identität dieser Verbindung mitα 1-Sitosterin

Summary The sterol fraction from leaves of the potato plant,Solanum tuberosum, was found to contain a minor constituent, the structure of which has been established as 4-methyl-5-stigmasta-7,24(28)-diene-3-ol (I). This sterol is most probably identical with ₁-sitosterol and has the same constitution as citrostadienol, differing only in the configuration of the ^{24 (28)}-double bond.

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Sterine und Triterpenoide. III. Mitteilung. — II. Mitteilung s. 3.     

Ein neues Verfahren zur Herstellung von 19-Norsteroiden

Summary The new methods for the production of 19-norsteroids described involve the conversion of 5-halogen-6-hydroxy-steroids into the corresponding 5-halogen-6:19-ethers either with lead tetraacetate or by the hypoiodite reaction^8,10. The 6:19-oxygen bridge is then opened reductively either directly or after oxidation of the 6:19-ethers to lactones or preferably after introduction of a ^4,6-3-oxo grouping. Acylolytic cleavage of the ⁴-3-oxo-6:19-ethers followed by alkaline hydrolysis gives ^4,6-3-oxo-19-hydroxy-steroids. The 19-hydroxycompounds formed are easily converted into 19-norsteroids by known methods.

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Über Steroide, 189. (vorläufige) Mitteilung; 188. Mitt. vgl.J. Kalvoda, J. Schmidlin, G. Anner undA. Wettstein, Exper.18, 398 (1962).     

Synthese von 22,26-Imino-cholestan-Derivaten

Summary 3, 16-diacetoxy-5-pregnane-20-one and the analogue pregn-5-ene derivative have been converted into (22R, 25R)-22, 26-imino-5-cholestane-3, 16-diol. The configuration at C-22 and C-25 was determined by transformation into the known (22R, 25R)-5-solanidane-3-one. Application of the Ruschig method led to (25R)-22,26-imino-5-cholest-22(N)-ene-3, 16-diol.

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Solanum-Alkaloide. XVI. Mitteilung. — XV. Mitteilung:K. Schreiber undH. Ripperger, Tetrahedron Letters Nr.27, 9 (1960).     

Contribution to the X-ray diffraction methods for precision determinations of polycrystal lattice parameters

. . : , . u-, .     

Unterliegt die Heimkehrgeschwindigkeit der Brieftauben hormonalen Einflüssen?

Summary The relation between the homecoming-speed of carrier-pigeons and the influence of sexhormones and prolaktin is reported.It is further examined whether the influence of prolaktin (breeding on 10–15 days old eggs) or psychological factors (feeding of young individuals of more than 15 days) are the factors, accelerating the homecoming-speed. Best results are obtained by combining breeding 1–6 days old eggs and feeding young pigeons of 2–3 weeks.

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In memoriam Heinz Knieriem zu seinem 15. Todestage     

Photolyse von N-Nitroso-22,26-iminocholestanen: Eine neue Synthese von Spirosolan-Alkaloiden

Summary Photolysis of N-nitroso-22,26-imino-5-cholestane-3,16-diols in acidic solution leads to the corresponding spirosolane alkaloids soladulcidine, solasodine and tomatidine, respectively.

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Photochemische Reaktionen, 5. Mitteilung. — 3. und 4. Mitteilung vgl.². Die vorliegende Arbeit ist zugleich 62. Mitteilung der ReiheSolanum-Alkaloide.