The benthic red alga Ceramium ciliatum var. robustum (J.Ag.) G. Mazoyer is a remarkable biological indicator of littoral mercury pollution]

The study of mercury composition of red Algae Ceranium ciliatum var. robustum, comparatively with other marine organisms and considering its growth and the extent of pollution at various harvesting points: reveals that this seaweed constitutes a conspicuous biological indicator for the littoral mercury pollution.     

5-Azacytidine,a new,highly effective cancerostatic

Zusammenfassung Die hohe bakteriostatische und cancerostatische Wirkung eines neuen Antimetaboliten, 5-Azacytidin, wird beschrieben.     

Measurement,coordination, and the relativized a priori

The problem of measurement is a central issue in the epistemology and methodology of the physical sciences. In recent literature on scientific representation, large emphasis has been put on the “constitutive role” played by measurement procedures as forms of representation. Despite its importance, this issue hardly finds any mention in writings on constitutive principles, viz. in Michael Friedman׳s account of relativized a priori principles. This issue, instead, was at the heart of Reichenbach׳s analysis of coordinating principles that has inspired Friedman׳s interpretation. This paper suggests that these procedures should have a part in an account of constitutive principles of science, and that they could be interpreted following the intuition originally present (but ultimately not fully developed) in Reichenbach׳s early work.     

Annonacin,a novel,biologically active polyketide fromAnnona densicoma

Summary A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark ofAnnona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.25 September 1986     

Baluchistine,a new bisbenzylisoquinoline alkaloid

Summary The new phenolic bisbenzylisoquinoline alkaloid (+)-baluchistine, found inBerberis baluchistanica Ahrendt (Berberidaceae), has been assigned structure1. O-Methylation using ethereal diazomethane yields (+)-obaberine (2). Baluchistine is the 1 alkaloid of the oxyacanthine-berbamine group to incroporate a free phenolic function at C-6.this project was supported by NIH research grant CA-11450, awarded by the National Cancer Institute, PHS/DHEW.     

Nifurpipone,a new nitrofuran with a large antimicrobial spectrum

Riassunto Il nifurpipone (5-nitro-2-furaldeide N'-metil-N-piperazino-acetidrazone) è un nuovo nitrofuranico a largo spettro antibatterico, escreto con le urine e quindi potenzialmente indicato nelle infezioni delle vie urinarie.     

Reticulol,a new metabolic isocoumarin

Zusammenfassung Die Struktur des ausStreptomyces rubreticulae isolierten neuen Isocumarins, Reticulol, ist als 3-Methyl-6,8-dihydroxy-7-methoxyisocumarin ermittelt worden.     

Inhibitory tripeptide,Lys-Phe-Tyr,as a fragment of physalaemin

Summary Several peptides were separated from-chymotrypsin-treated physalaemin by high voltage paper electrophoresis, and inhibition of the excitability of a molluscan giant neurone (tonically autoactive neurone) by the tripeptide, Lys-Phe-Tyr, was demonstrated.We thank Dr Sadaaki Iwanaga of Osaka University and Dr Atsuo Inoue of Daiichi Pharmaceutical CO for their helpful advice and the donation of the tripeptide (Lys-Phe-Tyr).     

Palinurin,a new linear sesterterpene from a marine sponge

Summary The structure of a new linear sesterterpene, palinurin (1), obtained from the marine spongeIrcinia variabilis, was determined by spectral and chemical means.This work was carried out at the Progetto Finalizzato Oceanografia e Fondi Marini, C.N.R., Roma. We thank Professor M. Sarà (University of Genova) for the identification of the sponge, Mr C. Di Pinto for¹H-and¹³C-NMR, Mr G. Scognamiglio for technical assistance.     

Crepitin,a phytohemagglutinin fromHura crepitans

Zusammenfassung Aus dem Saft des BaumesHura crepitans wurde eine Fraktion gewonnen, die wahrscheinlich ein Lipoglykoprotein ist und hämagglutinierende und toxische Eigenschaften besitzt.     

Annonacin, a novel, biologically active polyketide from Annona densicoma

A new linear polyketide, Annonacin (I), has been isolated from active extracts of the stembark of Annona densicoma Mart. Annonacin (I) is highly cytotoxic and is active in an assay designed to detect antimitotic agents. The structure of (I) was determined by analysis of spectroscopic data.