Studies on repairing of hemisected thoracic spinal cord of adult rats by using a chitosan tube filled with alginate fibers

A chitosan tube filled with alginate fibers was implanted into the injured spinal cord of a rat for repairing the damaged tissue. Twelve months after the operation, the morphological observation demonstrated that this chitosan tube could induce regeneration of myelinated and non-myelinated axons and blood vessels. The Basso-Beattie-Bresnahan (BBB) behavioral evaluation confirmed that the implants played a key role in the long-term restoration of rats motor functions. It is a promising start in the treatment of the patients with the injury of the spinal cord.     

补阳还五汤对脊髓损伤大鼠体重及后肢运动功能的影响

目的探讨补阳还五汤对脊髓损伤大鼠体重及后肢运动功能影响与其神经保护作用的关系。方法采用Allen’s打击法制作中度SCI模型,应用SPF级Wistar大鼠,随机分为4组：正常组和3个模型组,即模型空白组、BYHWD组、金纳多组,每组16只大鼠。模型组大鼠分别给予蒸馏水、BYHWD、金纳多水溶液,正常组给予蒸馏水,分别于造模前即0 d、造模后3 d、1 w、2 w、3 w,称量大鼠体重,并进行后肢运动功能评价,灌胃治疗2 w后,结束实验。结果SCI模型大鼠于造模后3 d体重及后肢运动功能均明显降低,灌胃治疗后,模型空白组大鼠体重缓慢增加,但后肢运动功能无明显改善;BYHWD组及金纳多组大鼠体重及后肢运动功能均有显著改善,且BYHWD组改善效果更明显,与金纳多组比较差异有显著性。结论BYHWD通过保护SCI大鼠脊髓组织,显著改善大鼠后肢运动功能,增加大鼠体重,为其治疗中医＂痿证＂提供了新的实验依据。