Corticotropin releasing factor induction of leukocyte-derived immunoreactive ACTH and endorphins

Human peripheral leukocytes infected by virus or treated with endotoxin will, like unstimulated mouse spleen macrophages, synthesize immunoreactive corticotrophin (ir-ACTH) and endorphins. The ir-ACTH produced appears to be identical with authentic ACTH, while enough of the material has been produced in hypophysectomized mice infected with virus to demonstrate a steroidogenic response. Because the production of ACTH by in vivo pituitary cells and by leukocytes is suppressed by dexamethasone both in vitro and in vitro, suggesting that the production of ACTH and endorphins by leukocytes is indeed controlled, we have investigated the effects of corticotropin releasing-factor (CRF), which is known to regulate the pituitary production of both ACTH and beta-endorphin. We now report that the production of ACTH and endorphins by leukocytes is indeed induced by synthetic CRF and, in turn, suppressed by dexamethasone, suggesting that, as in pituitary cells, the proopiomelanocortin (POMC) gene may be expressed and similarly controlled in leukocytes.     

Corticotropin regulates transsynaptically the activity of septo-hippocampal cholinergic neurones

The activity of septo-hippocampal neurones is affected by the action on cholinergic perikarya in the septum of a variety of putative neurotransmitters, including substance P and beta-endorphin. (The latter is released in the septal region from neurones which originate in the medial basal hypothalamus.) It has also been reported that two other neuropeptides, corticotropin (ACTH1-24) and alpha-melanotropin (alpha-MSH), affect acetylcholine turnover in septo-hippocampal neurones in a manner that is not blocked by transection of the afferents to the hippocampus, from which it has been inferred that the neurotransmitters act directly on the hippocampus. We now describe experiments with corticotropin which show that the effect is rather the influence on septo-hippocampal cholinergic neurones of peptidergic neurones within the septum.     

论新时期高校校园文化建设

高校校园文化建设是新时期高等教育改革的重要内容.通过对校园文化的基本认识,结合我国目前高校校园文化的发展现状,提出关于新时期校园文化建设的建议.     

Dirichlet积分的几种新证明

借助积分交换次序与积分号下求导 复变函数、积分变换、数学物理方程等数学方法和工具,通过三种途径证明Dirichlet积分?     

Carboxy terminus of vasopressin required for activity but not binding

Vasopressin antagonists are valuable pharmacological tools for investigating physiological and behavioural functions of the nonapeptide arginine-vasopressin (AVP). The removal of glycinamide from the carboxy terminus of AVP drastically reduces its characteristic vasopressor and antidiuretic activities. In contrast to this we show here that removal of the carboxy-terminal glycinamide or the glycine at position 9 from several vasopressin antagonists makes little difference to their ability to block vasopressor and antidiuretic responses to AVP. These data demonstrate the critical structural requirements of the carboxy-terminal position for receptor activation, in contrast to the lack of such requirements for receptor binding. They also provide an avenue to a wide variety of antagonists substituted at the carboxy terminus (for example radiolabelled derivatives and affinity ligands) and suggest clues for the development of more potent and/or selective antagonists.     

Inhibition of the firing of vasopressin neurons by atriopeptin

Atriopeptin, the atrial natriuretic peptide, is a circulating hormone that is released from the atria of mammalian hearts in response to volume expansion and acts upon the kidneys, adrenal glands and vasculature to regulate fluid and electrolyte homeostasis. Atriopeptin is also present in the brain of the rat. Atriopeptin immunoreactive cell bodies and fibres are found in many areas known to be involved in the central regulation of the cardiovascular system, suggesting that it may be a neuromediator in the central control of fluid and electrolyte balance. The paraventricular nucleus of the hypothalamus, which contains the cell bodies of neurons that secrete vasopressin from the posterior pituitary gland, receives a dense innervation from atriopeptin-like immunoreactive fibres. We have studied the effect of atriopeptin on the electrical activity of single neurons in the paraventricular nucleus of anaesthetized rats and found that atriopeptin is a potent inhibitor of putative vasopressin neurons. Atriopeptin, which has systemic actions that oppose those of vasopressin, may act as a neuromodulator in the brain to prevent vasopressin secretion.     

浅谈通风空调几项新技术

文章从置换通风的工作原理、置换通风系统的适用范围、置换通风与地板送风的区别等几个方面论述了置换通风这一新技术,并简要介绍了一次泵变流量系统和温湿度独立控制空调系统。     

试论新时期大学校报的发展

新时期的大学校报是大学引导舆论、沟通信息的媒体，是大学传承精神、传播理念的载体，在大学展示形象、对外交流的窗口，是大学教书育人、素质教育的园地。新时期大学校报的发展趋势是体现个性，辐射社会；利用网络、拓展时空，注重策划，增加版栏。新时期大学校报发展的基本措施是转变观念；提升地位，加大投入，更新设备，规范机制，加强队伍。     

新媒体时代的公共关系课程教学研究

新媒体的数字性、网络性、快捷性、交互性、自主性和跨时空性为公共关系学的教学带来了诸多便利.新媒体时代公关课程的教育理念、教学内容、教学方法、教学手段、教师和学生的角色转化、考核方式都面临着转变和创新.教师应借助新媒体时代信息的快捷传播,寻找企业最新的、最真实的公关思路和举措,来推动公关课程教学.     

Gamma-interferon is one of several direct B cell-maturing lymphokines

Two classes of molecules often released after the interaction of T lymphocytes, macrophages and antigen are B-cell maturation factors (BMF)1-3 and immune (gamma) interferon (IFN-gamma)4-7. BMFs directly induce the maturation of resting B lymphocytes to the state of active immunoglobulin secretion, while IFN-gamma is defined by the reduction of viral infectivity in vitro. However, interferons have been shown to have a variety of effects and they have also been reported both to increase and decrease B-cell differentiation in intact animals and complex cellular mixtures in vitro. Here we show that murine IFN-gamma produced by recombinant DNA technology shows similar biological effects to BMFs from two other sources. All three preparations induce immunoglobulin secretion by both normal resting murine splenic B cells and the comparable B-cell tumour line WEHI-279.1 (refs 1, 3). IFN-gamma and the other two BMFs are not identical, however, as anti-IFN-gamma antibodies block the effects on B cells of IFN-gamma, but not those of the other two lymphokines. IFN-gamma may be one of several molecules with a direct role in driving the maturation of resting B cells to active immunoglobulin secretion.     

几种新型超分子配合物的合成和表征

制备3种新型超分子配合物并运用常规方法进行表征,讨论配体的特征骨架、空间配位方式和氢键作用对超分子形成的影响.以实验证实,从分子设计,通过分子自组装,是合成具有超分子结构配合物的有效途径.同时培养出化合物的高质量单晶,解析了晶体结构,分析和探讨了超分子配合物的组成-结构-性质之间的关系.     

新型甲醛吸收剂的制备与应用研究

制备了两种丙烯酸酰联氨高分子化合物,并选择了酰胺类、酰肼类、有机胺类、无机铵盐类的水溶液及其混合物与制备的丙烯酸酰联氨高分子化合物混合作为甲醛吸收剂,涂布于木板和聚氯乙稀胶片（以白乳胶为基质）,进行甲醛的吸收与消除测试．根据测试结果,制作的甲醛吸收剂能起到较好的甲醛吸收与消除效果．     

Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats

In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.     

新时期思想政治工作创新的思考

新时期思想政治工作正面临着国际、国内一系列复杂环境变化的影响,如何创新性的开展思想政治工作显得尤为重要。通过对新时期思想政治工作创新的必要性进行分析,指出了思想政治工作创新的主要趋向是理论创新、人文关怀和心理疏导,并从思想观念、教育内容、载体、方法、机制等方面作为着力点对思想政治工作创新进行了探讨。