共查询到20条相似文献,搜索用时 15 毫秒
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Direct activation of RNA polymerase III transcription by c-Myc 总被引:13,自引:0,他引:13
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A cDNA encoding RAP74, a general initiation factor for transcription by RNA polymerase II. 总被引:15,自引:0,他引:15
A Finkelstein C F Kostrub J Li D P Chavez B Q Wang S M Fang J Greenblatt Z F Burton 《Nature》1992,355(6359):464-467
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Factor stimulating transcription by RNA polymerase 总被引:106,自引:0,他引:106
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The RNA polymerase elongation complex (EC) is both highly stable and processive, rapidly extending RNA chains for thousands of nucleotides. Understanding the mechanisms of elongation and its regulation requires detailed information about the structural organization of the EC. Here we report the 2.5-A resolution structure of the Thermus thermophilus EC; the structure reveals the post-translocated intermediate with the DNA template in the active site available for pairing with the substrate. DNA strand separation occurs one position downstream of the active site, implying that only one substrate at a time can specifically bind to the EC. The upstream edge of the RNA/DNA hybrid stacks on the beta'-subunit 'lid' loop, whereas the first displaced RNA base is trapped within a protein pocket, suggesting a mechanism for RNA displacement. The RNA is threaded through the RNA exit channel, where it adopts a conformation mimicking that of a single strand within a double helix, providing insight into a mechanism for hairpin-dependent pausing and termination. 相似文献
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J Sommerville 《Nature》1984,310(5974):189-190
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Breaks in DNA stimulate transcription by core RNA polymerase 总被引:8,自引:0,他引:8
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RNA polymerase II elongation through chromatin 总被引:21,自引:0,他引:21
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