Stilboestrol-induced depression of the antibody response

Résumé On a étudié l'effet du stilboestrol sur la formation d'anticorps contre de hématies de mouton chez les rats et les souris. Un traitement préliminaire au stilboestrol affaiblissait chez les rats et les souris la réponse exprimée en termes d'anticorps hémolytiques et agglutinants. On a montré que cet effet dépendait de la dose et de la voie d'administration de l'antigène. On discute brièvement les mécanismes susceptibles d'expliquer cette diminution.

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This work was supported in part by the Medical Research Council.

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G.G.W. is in receipt of a Medical Research Council Scholarship.     

Delayed hypersensitivity and antibody response in rheumatoid arthritis

Zusammenfassung Es wird über die immunologische Reaktivität von Patienten mit progressiver Polyarthritis berichtet. Nach Injektion von 25 E Streptokinase (Präparat Dornokinase) zeigten die Patienten eine gewisse Dissoziation der immunologischen Vorgänge: Herabsetzung der Hautreaktionen und erhöhte spezifische Antikörperreaktion.     

Primary antibody response in mice bearing leukemia L1210

Riassunto La risposta immunitaria primaria a globuli rossi di montone, studiata mediante la tecnica delle placche di Jerne in topi CDF₁ normali o portatori di leucemia L1210, indica che lo sviluppo neoplastico deprime la formazione di anticorpi umorali solo nel caso in cui l'antigene venga iniettato in fase avanzata della malattia.

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Supported in part by contract No. PH-43-68-1283 with Chemotherapy, National Cancer Institute, National Institutes of Health.     

Necessity of adjuvants for inducing effective antibody response to zona pellucida antigens

Rhesus monkeys evoked a vigorous antibody response to a single heteroimmunization dose of zona pellucida antigens, when these were administered along with complete Freund's adjuvant. The antisera recognized all the three major porcine zona glycoprotein families and the animals were rendered amenorrheic after such immunization. Monkeys immunized with zona without adjuvant, however, failed to show any anti-zona antibody response and had normal menstrual cycles. Zona pellucida glycoproteins are thus not effective immunogens unless administered along with a powerful adjuvant.     

Suppression and enhancement of humoral immune response toToxoplasma gondii by passive antibody

Summary Anti-toxoplasma antibodies administered passively to mice may lead to suppression or enhancement (reported for the first time with Protozoan parasites) of subsequent antibody response when these animals are later infected withToxoplasma gondii. The outcome is dependent on infecting strain of Toxoplasma and the antigen-antibody ratio.     

Necessity of adjuvants for inducing effective antibody response to zona pellucida antigens

Summary Rhesus monkeys evoked a vigorous antibody response to a single heteroimmunization dose of zona pellucida antigens, when these were administered along with complete Freud's adjuvant. The antisera recognized all the three major porcine zona glycoprotein families and the animals were rendered amenorrheic after such immunization. Monkeys immunized with zona without adjuvant, however, failed to show any anti-zona antibody response and had normal menstrual cycles. Zona pellucida glycoproteins are thus not effective immunogens unless administered along with a powerful adjuvant.     

Suppression and enhancement of humoral immune response to Toxoplasma gondii by passive antibody

Anti-toxoplasma antibodies administered passively to mice may lead to suppression of enhancement (reported for the first time with Protozoan parasites) of subsequent antibody response when these animals are later infected with Toxoplasma gondii. The outcome is dependent on infecting strain of Toxoplasma and the antigen-antibody ratio.     

Suppression of the secondary immune response by specific antibody,when given together with the secondary antigenic stimulus

Summary It is generally believed that antibody-mediated immunosuppression can be only produced in non-primed individuals, and that this applies both to experimental animals and Rh-negative women at risk. However, in this paper it is reported that the additional injection of 0.2 ml of an antiserum to sheep erythrocytes (SE) together with a secondary antigenic stimulus of 10⁸ SE into mice, primarily immunized by a tiny dose of 5×10⁵ SE 28 days before, was capable of producing effective suppression of the secondary immune response.This work was supported by grants from the Deutsche Forschungsgemeinschaft.     

Suppression of the secondary immune response by specific antibody, when given together with the secondary antigenic stimulus.

It is generally believed that antibody-mediated immunosuppression can be only produced in non-primed individuals, and that this applies both to experimental animals and Rh-negative women at risk. However, in this paper it is reported that the additional injection of 0.2 ml of an antiserum to sheep erythrocytes (SE) together with a secondary antigenic stimulus of 10(8) SE into mice, primarily immunized by a tiny dose of 5 x 10(5) SE 28 days before, was capable of producing effective suppression of the secondary immune response.     

Effect of actinomycin D on white blood count and humoral antibody response in hamsters

Zusammenfassung Actinomycin D fÜhrt bei erwachsenen männlichen Hamstern in einer Dosis, die fÜr 15% der Tiere letal ist, zu einem vorÜbergehenden Abfall der Lymphozyten und zu einem kontinuierlichen Anstieg der neutrophilen Granulozyten. Die Bildung agglutinierender Antikörper gegen Schaferythrozyten wird dagegen, unabhängig von der Antigendosis und vom Zeitpunkt der Antigenapplikation, durch Actinomycin D nicht beeinflusst.     

Induction of antibody response in lymphoid cells in vivo and in vitro by RNA-immuno-carrier from immune serum

Riassunto Nel siero di animali immunizzati è presente un RNA depositario del modello anticorpale che è capace di indurre la formazione di anticorpi in cellule linfoidi normali in vivo ed in vitro, sia di origine timica che splenica.     

Rapid recruitment and proliferation of antibody plague-forming cells in the absence of natural antibody

Zusammenfassung Nachweis, dass «Plaque»-bildende Antikörperzellen gegen somatische Antigene vonVibrio cholerae sich in der Milz immunisierter Mäuse schnell und «treppenartig» nach übereinstimmender Latenzzeit von 42 h entwickeln, ohne dass dabei ein «background» an Antikörper bildenden Zellen zu erfassen war.     

Suppressor effect induced by sodium periodate on the antibody response of mouse splenic cells in vitro : inhibition of this effect by sodium borohydride]

Mild oxidation of mouse spleen cells by sodium periodate induces blastogenesis. Concomitantly, the in vitro response of these cells to sheep red blood cells is inhibited. Exposure of spleen cells to sodium borohydride following periodate treatment reduces blastogenesis and restores the immune response.     

Ageing and antibody production in the rat

Résumé La production d'anticorps antiprotéiques a été étudiée comparativement chez des rats de 3 mois et de 22 mois, par la méthode d'hémagglutination passive. Les résultats montrent et précisent la différence de comportement immunologique entre animaux jeunes et animaux âgés.