共查询到20条相似文献,搜索用时 15 毫秒
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Zusammenfassung Bei Ratten, die durch einseitige Nierenexstirpation und 1% NaCl als Trinkflüssigkeit sensibilisiert wurden, war die Nephrosklerose, die normalerweise durch das Desoxycorticosteronacetat (DOCA) hervorgerufen wird, durch gleichzeitige Zufuhr von Cortisolacetat (COLA) noch verstärkt. Einschränkung der Nahrungszufuhr kann die Produktion von Nephrosklerose durch DOCA vollkommen verhindern, Unterernährung hat jedoch viel weniger Einfluss auf das Entstehen derartiger Nierenveränderungen nach gleichzeitiger Behandlung mit DOCA und COLA. 相似文献
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M. W. Fox 《Cellular and molecular life sciences : CMLS》1966,22(2):111-112
Zusammenfassung Die Relation Gehirnmasse/Körpergewicht wurde bei 83 Hunden von Geburt bis zum Adultzustand studiert. Ein Bruch in der linearen Relation zwischen den Logarithmen Gehirngewicht und Körpergewicht trat ungefähr im Alter von vier Wochen ein (1,5 kg Körpergewicht zu 37 g Gehirngewicht). Dies betrifft einen kritischen Punkt in der Neuro-Ontogenie, was im Zusammenhang mit anderen Erscheinungen der ZNS- und Verhaltensentwicklung steht. 相似文献
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M W Fox 《Experientia》1966,22(2):111-112
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B. Durst-Živković 《Cellular and molecular life sciences : CMLS》1977,33(10):1371-1372
Summary The effect of deficient nutrition of pregnant Wistar rats on the fetal weight has been studied. It has been established that the fetal weight of the group of rats fed with a restricted amount of stock diet lags behind the fetal weight of the group receiving unrestricted amounts of the same stock diet. The differences in weight between the 2 groups were, on each day of the observation period, significant at the level of p<0.05 and p<0.01, respectively.This work was supported by a grant of the Republic Research fund of Croatia No. 18-04-06/19-1975. 相似文献
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A. A. Smith 《Cellular and molecular life sciences : CMLS》1971,27(5):542-542
Zusammenfassung In Mäusen entsteht eine Toleranz gegen den kataraktogenen Effekt einer Einzeldosis von Opioid. Werden fraktionierte Dosen gegeben, so entwickelt sich jedoch eine weitaus grössere Toleranz, wofür eine Sensibilisierung als Ursache angenommen wird.
Supported by a grant No. MH-12988-05 from the United States Public Health Service. 相似文献
Supported by a grant No. MH-12988-05 from the United States Public Health Service. 相似文献
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Summary By means of the HRP method it was shown that the entire cerebral cortex, but in greater proportion the frontal and posterior temporo-parietal regions, receive fibres from the dorsal and medial raphe nuclei and from the locus coeruleus. In contrast, the pars compacta substantiae nigrae and the tegmental area send projections to the motor and cingular areas respectively. 相似文献
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Ruminations on dietary restriction and aging 总被引:6,自引:0,他引:6
Kennedy BK Steffen KK Kaeberlein M 《Cellular and molecular life sciences : CMLS》2007,64(11):1323-1328
Calorie restriction has been known for many decades to extend the life span of rodents. Since the more recent discovery that
a long-term reduction in nutrient intake also extends life span in nearly every invertebrate model organism used for aging
research, the mechanisms behind the longevity benefits of this intervention have been under intense scrutiny. While models
have been developed in yeast, worms, and flies, the molecular mechanisms governing life span extension by calorie restriction
remain controversial, resulting in great anticipation of mammalian studies testing these models. Here we discuss the links
between nutrient reduction and enhanced longevity with emphasis on evolutionarily conserved nutrient response signaling.
Received 1 November 2006; received after revision 15 December 2006; accepted 27 February 2007 相似文献
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Primary cilia are singular, cytoskeletal organelles present in the majority of mammalian cell types where they function as coordinating centres for mechanotransduction, Wnt and hedgehog signalling. The length of the primary cilium is proposed to modulate cilia function, governed in part by the activity of intraflagellar transport (IFT). In articular cartilage, primary cilia length is increased and hedgehog signaling activated in osteoarthritis (OA). Here, we examine primary cilia length with exposure to the quintessential inflammatory cytokine interleukin-1 (IL-1), which is up-regulated in OA. We then test the hypothesis that the cilium is involved in mediating the downstream inflammatory response. Primary chondrocytes treated with IL-1 exhibited a 50% increase in cilia length after 3 h exposure. IL-1-induced cilia elongation was also observed in human fibroblasts. In chondrocytes, this elongation occurred via a protein kinase A (PKA)-dependent mechanism. G-protein coupled adenylate cyclase also regulated the length of chondrocyte primary cilia but not downstream of IL-1. Chondrocytes treated with IL-1 exhibit a characteristic increase in the release of the inflammatory chemokines, nitric oxide and prostaglandin E2. However, in cells with a mutation in IFT88 whereby the cilia structure is lost, this response to IL-1 was significantly attenuated and, in the case of nitric oxide, completely abolished. Inhibition of IL-1-induced cilia elongation by PKA inhibition also attenuated the chemokine response. These results suggest that cilia assembly regulates the response to inflammatory cytokines. Therefore, the cilia proteome may provide a novel therapeutic target for the treatment of inflammatory pathologies, including OA. 相似文献
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R. M. Donati M. E. Johnson C. A. Stancer LW. R. Stromberg 《Cellular and molecular life sciences : CMLS》1968,24(5):451-452
Zusammenfassung Verabreichung vond-, wie auch vonl-Triiodothyrosin erzeugt eine ähnliche Vermehrung der Erythropoiesis in nephroektomierten Ratten, wie bei der Messung der Radioeiseninkorporation durch Erythrozyten (18 h nach Injektion von radioaktivem Eisencitrat). Es ergab sich weiter, dassd- undl-Thyrosin, im Unterschied zu Erythropoieten, die reticulozytose Eisenassimilation in vitro vermehrte. Danach scheinen verschiedene Mechanismen bei der Stimulation der Erythropoiesis durch Erythropoieten und Triiodothyronin im Spiele zu sein. 相似文献
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By means of the HRP method it was shown that the entire cerebral cortex, but in greater proportion the frontal and posterior temporo-parietal regions, receive fibres from the dorsal and medial raphe nuclei and from the locus coeruleus. In contrast, the pars compacta substantiae nigrae and the tegmental area send projections to the motor and cingular areas respectively. 相似文献
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Summary Hypertension was produced in anesthetized and conscious dogs when cerebral perfusion was reduced. It lasted up to 19 days in chronic studies, was not abolished by carotid sinus denervation nor with beta receptor blockade, but was absent after removal of brachiocephalic artery constriction (BCAC). The cardiovascular features of this neurogenic hypertension are presented. 相似文献
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P. N. Bhaduri S. N. Das K. K. Lahiri 《Cellular and molecular life sciences : CMLS》1967,23(9):784-785
Zusammenfassung Es wird gezeigt, dass kristallines Phytohaemagglutanin (PHA) oder Rohextrakt aus PHA enthaltenden Zuckerbohnen (Phaseolus vulgaris) das Wachstum vonRhizobium dadurch beeinflusst, dass die Lagphase der Wachstumskurve verkürzt, die logarithmische Phase aber verlängert wird. Die PHA-Wirkung ist deutlicher bei denRhizobium-Linien, die in den Wurzelknöllchen des Wirts an PHA nicht adaptiert sind. 相似文献
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I. H. Rorison 《Cellular and molecular life sciences : CMLS》1986,42(4):357-362
Summary Interactive effects between acid deposition and the rest of the environment are the key to further understanding. Although this article deals only with plant growth in relation to the chemical state of the soil and not with aerial effects, it is still possible to illustrate a number of interactions and patterns of response among both vascular and non-vascular components of vegetation. Evidence is examined with regard to plant age, pre-treatment and the nature of nutrient supply. It includes consideration of both effects of soil on plants and of plants on soil, notes both antagonisms and symbioses, and draws attention to inducible defence systems. 相似文献
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Summary Lipopolysaccharide (LPS) applied to the anterior brainstem of the carp caused lightening of body colour. This indicates that an increase in set point temperature is responsible for increased cutaneous autonomic activity following LPS-administration.We express thanks to Dr S. Kanoh, National Institute of Hygenie Sciences, Osaka, Japan, for suppling the LPS. 相似文献