Effects of lithium chloride on peripheral acetylcholine release and brain acetylcholine levels in the guinea-pig

Summary Lithium chloride administered acutely or chronically to guinea-pigs had no effect on brain level of acetylcholine or on peripheral release of acetylcholine from longitudinal muscle of the ileum. The results suggest differences between in vitro and in vivo action of lithium.To whom correspondence should be addressed.     

Effects of early undernutrition and subsequent rehabilitation on acetylcholine levels in rat brain

Summary Early undernutrition, induced by feeding mothers a low protein (5%) diet during gestation and/or lactation, resulted in significant deficits in acetylcholine concentration in the rat brain, and these deficits were reversed by subsequent dietary rehabilitation.This research was partly supported by Nutrition Society of India Grant-in-Aid Award (79/60) to Dr A.B. Kulkarni. We would like to thank Dr A.J. Baxi for valuable discussions throughout the course of these studies.     

Effects of lithium chloride on normal and neoplastic cells in vitro

Résumé L'action du lithium (LiCl) a été étudiée comparativement sur des cellules néoplasiques humaines KB et normales de rein de singe. Les résultats obtenus démontrent que le LiCl en concentrations égales et supérieures à 5.10^–2 M entraîne une inhibition significative de la prolifération des deux types cellulaires. D'autre part, pour des temps d'exposition supérieurs à 24h, cet effet cytoinhibiteur s'accompagne d'une diminution de la quantité des RNA cytoplasmiques. Ces effets du LiCl apparaissent sélectifs par rapport à ceux du NaCl utilisés en concentrations équimoléculaires.     

The stimulation of rat brain monoamine oxidase by dietary lithium chloride.

Lithium chloride administered to rats in drinking water for 30 days caused an increase of whole brain monoamine oxidase specific activity to approximately 140% of control. Carboxylesterase and formyltetrahydrofolate synthetase activities were not affected by Li+ either in vivo or in vitro.     

The stimulation of rat brain monoamine oxidase by dietary lithium chloride

Summary Lithium chloride administered to rats in drinking water for 30 days caused an increase of whole brain monoamine oxidase specific activity to approximately 140% of control. Carboxylesterase and formyltetrahydrofolate synthetase activities were not affected by Li⁺ either in vivo or in vitro.Contribution of the Nevada Agricultural Experiment Station (Reno), Journal Series No. 439.     

Adaptation of the guinea-pig to histamine. sensitivity of the guinea-pig's ileum to histamine and acetylcholine

Résumé L'adaptation des cobayes à l'histamine par voie intrapéritonéale diminue la sensibilité de leur jéjunum isolé à l'histamine. En même temps le jéjunum isolé de cobayes adaptés réagit à l'acétylcholine sans changer remarquablement de susceptibilité. L'activité de l'histaminase dans le jéjunum adapté ne démontre pas la différence en relation avec celle du jéjunum non adapté.

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The study was supported by the Polish Academy of Sciences.     

Effect of hydroxydopamine on the morphine-induced reduction in brain acetylcholine turnover

Summary Morphine reduced brain acetylcholine turnover in normal and 6-hydroxydopamine-pretreated rats and mice. Morphine probably has a direct effect on cholinergic neurons rather than modifying acetylcholine indirectly through catecholamine neurons. Acetylcholine is not directly involved in morphine's antinociceptive action in the mouse but it could be implicated in the rat.     

Effect of hydroxydopamine on the morphine-induced reduction in brain acetylcholine turnover

Morphine reduced brain acetylcholine turnover in normal and 6-hydroxydopamine-pretreated rats and mice. Morphine probably has a direct effect on cholinergic neurons rather than modifying acetylcholine indirectly through catecholamine neurons. Acetylcholine is not directly involved in morphine's antinociceptive action in the mouse but it could be implicated in the rat.     

Effects of chronic lithium administration on concanavalin A binding to plasma membranes from the corpus striatum of rat brain.

The effects of chronic in vivo lithium administration on mannose-containing components of plasma membranes from rat corpus striatum were examined by a 3H-concanavalin A binding displacement method. No difference on Con A binding was observed between sodium or lithium-treated rats during a 1-month period.     

Effect of lithium on brain aconitase activity

Résumé Nous avons déterminé l'activité spécifique de l'aconitase cérébrale des souris après une période de 108 jours de traitement avec du lithium (Li₂CO₃). Une inhibition significative de l'enzyme à été observée. D'autre part, nous n'avons trouvé in vitro aucun effet du Li₂CO₃ sur l'aconitase cérébrale.

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R. R. A. was supported by a research grant from the Conselho Nacional de Pesquisas (National Research Council of Brasil).     

Ouabain-induced release of extraneuronal catecholamine in the isolated guinea-pig vas deferens

Summary It was found that ouabain (10^–5 M) was effective in releasing the extraneuronal catecholamine which was taken up by uptake₂ process in the guinea-pig vas deferens. This result shows that a Na–K ATPase is essential for the storage of catecholamine in the extraneuronal site.     

Estimation of rat brain acetylcholine I. Effect of time lapse between killing and freezing of the brain

Zusammenfassung Es wird nachgewiesen, dass die Zeitspanne, die für die Extraktion von Acetylcholin gebraucht wird, auf seine quantitative Bestimmung entscheidend ist.     

Effects of alpha- and beta-adrenergic blockers on the actions of noradrenaline on body temperature in the newborn guinea-pig.

The effect of NA injected into the lateral cerebral ventricle on Tc was blocked by alpha-adrenergic receptor blockers, but not by beta-receptor blockers, whereas the effect of systemically administered NA was blocked by i.p. administered beta-receptor blockers, but not by alpha-blockers.