Distribution of monoamine oxidase in hippocampal region of the rat

Summary The distribution and development of type A and type B monoamine oxidase (MAO) activities in the hippocampal region of the rat was investigated with biochemical microdetermination. Type A MAO is absolutely dominant and unevenly distributed in the hippocampus. The development of type A MAO in the hippocampus seems to be delayed and reachs adult levels by the 30th day after birth.     

Effect of some monoamine oxidase inhibitors on deamination of biogenic monoamines by rat liver mitochondrial monoamine oxidase

N--N- MAO , , .     

Distribution of type A and B monoamine oxidase activities in the central nervous system of rat and chick

Summary The distribution of type A and B monoamine oxidase (MAO) activities in the central nervous system (CNS) of rat and chick was investigated using 5-hydroxytryptamine and -phenylethylamine as specific substrates. The distribution of type A MAO was similar to that of type B MAO in rat CNS, but quite different in chick CNS. This may be ascribed to the difference in animal species. The major part of MAO activity in the spinal cord was found to be type A.     

The stimulation of rat brain monoamine oxidase by dietary lithium chloride

Summary Lithium chloride administered to rats in drinking water for 30 days caused an increase of whole brain monoamine oxidase specific activity to approximately 140% of control. Carboxylesterase and formyltetrahydrofolate synthetase activities were not affected by Li⁺ either in vivo or in vitro.Contribution of the Nevada Agricultural Experiment Station (Reno), Journal Series No. 439.     

Distribution of noradrenaline and of monoamine oxidase and catechol-O-methyltransferase activity in human foetal heart

Zusammenfassung Die Konzentration von Noradrenalin und die Aktivität der MAO und COMT wurde in verschiedenen Teilen des menschlichen foetalen Herzens bestimmt. Die Ventrikel der Herzen (bis zu 12 Wochen alt) waren sehr noradrenalinarm. Die COMT-Aktivität des rechten Vorhofs war bis zur Mitte der Schwangerschaft viel niedriger als die der übrigen Herzgebiete. Die COMT- und MAO-Aktivität im Gewebe des Spatium zwischen der Aorta und der Arteria pulmonalis lag ungefähr in der gleichen Grössenordnung wie die der Ventrikel.     

Affinity chromatography of monoamine oxidase

Summary A method is described for the purification of pig liver monoamine oxidase by affinity chromatography, using a colum with covalently bound pargyline.Acknowledgment. The authors wish to thank the University Research Council for financial support.     

The stimulation of rat brain monoamine oxidase by dietary lithium chloride.

Lithium chloride administered to rats in drinking water for 30 days caused an increase of whole brain monoamine oxidase specific activity to approximately 140% of control. Carboxylesterase and formyltetrahydrofolate synthetase activities were not affected by Li+ either in vivo or in vitro.     

Increase of pyruvic and lactic acid in rat blood by inhibitors of monoamine oxidase

Zusammenfassung Monoaminoxydase(MAO)-Hemmer verschiedener chemischer Klassen sowie Monoamin-Freisetzer erhöhen den Milch- und Brenztraubensäuregehalt im Rattenblut. Der zeitliche Verlauf dieser Vermehrung verhält sich ähnlich wie die 5-Hydroxytryptamin-Akkumulation bzw. -Freisetzung im Gehirn. Im weiteren verstärkt der MAO-Hemmer Iproniazid den durch 5-Hydroxytryptamin oder Noradrenalin bedingten Anstieg von Milch- und Brenztraubensäure im Blut.     

Multiplicity of monoamine oxidase in chick brain

Summary The substrate- and inhibitor-related characteristics of monoamine oxidase (MAO) were studied on chick brain mitochondria. It was found that neither 5-hydroxytryptamine nor -phenylethylamine is the specific substrate for type A and type B MAO in chick brain.     

Inhibition of rat testicular monoamine oxidase activity after 250 R of whole-body X-irradiation

Résumé Chez le rat l'activité de l'oxydase testiculaire monoaminée est augmentée d'une manière significative 7 à 10 jours après une irradiation-X de 250 R du corps entier. Elle s'est abaissée au-dessous de la valeur du contrôle pendant les 153 jours qui suivirent le traitement.

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This research was sponsored by Utah State University Research Project U-300, and U.S. Atomic Energy Commission Grant No. AT(11-1)-1602.     

Effect of adrenalectomy and dexamethasone treatment on the monoamine oxidase activity in the thyroid gland of the rat

Summary Adrenalectomy increased MAO activity in the thyroid gland of rats. The administration (200 g/100 g daily for 7 days) to adrenalectomized rats decreased MAO activity below levels of intact controls.     

Ontogenesis of monoamine oxidase in the thyroid gland of rats

Summary During postnatal development, MAO activity in the thyroid gland of male rats increases until day 16, when adult values are reached.     

Cadmium-induced inhibition of brain monoamine oxidase in the freshwater catfish

Summary The freshwater catfishClarias batrachus (L.), exposed to 50 ppm of cadmium (Cd) chloride for a period of 135 days exhibited marked inhibition of brain monoamine oxidase (MAO) (p<0.001). The retarded gonadal growth observed in the present study suggests that Cd may be capable of creating imbalance in the aminergic activity of the hypothalamus, which modulates the secretion and release of gonadotropins.Acknowledgment. Financial assistance from the Council of Scientific and Industrial Research of India made this work possible.     

Effects of thyroidectomy on monoamine oxidase activities toward tyramine and serotonin in the circumventricular nuclei of the rat

Summary Following thyroidectomy, monoamine oxidase (MAO) activities toward tyramine decreased significantly by 20% in the nucleus periventricularis and the nucleus arcuatus among the 3 hypothalamic nuclei of the rat, while MAO activity toward serotonin decreased significantly by 10% only in the nucleus periventricularis. It is suggested that thyroidectomy induced selective changes on the multiple forms of MAO in the discrete circumventricular nuclei.     

Multiplicity of monoamine oxidase in chick brain.

The substrate- and inhibitor-related characteristics of monoamine oxidase (MAO) were studied on chick brain mitochondria. It was found that neither 5-hydroxytryptamine nor beta-phenylethylamine is the specific substrate for type A and type B MAO in chick brain.     

Occurrence of mitochondrial monoamine oxidase in human semen

Summary Mitochondrial monoamine oxidase (MAO) was found in human semen, showing its K_m and V_max values of 91.7 M and 290 pmoles/mg of protein/60 min, respectively, with kynuramine as substrate. A major part of the activity was due to type A MAO.