Mass spectrometric determination of the amino acid sequence in arginine-containing peptides

aa, a-a a- a aa - aa a -a .     

Topochemical approach to the structure-activity relation. Retroenantio-Gly5,10-gramicidin S

, . , -Gly^5,10- , Gly^5,10- .     

Separation of rat liver mitochondrial amine oxidases

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Magnug reflexex of the chest musculature in man

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The effect of chloramphenicol analogs on protein biosynthesis in a cell-freeEscherichia coli B system

a aaa a aa aa a a E. coli aa, a aa aa a , a a aa - a .

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Laboratory of Biological Investigations.

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Laboratory for Chemistry of Antibiotics.     

Inhibition of sodium transport in frog skin by cardiac glycosides of different molecular structure

p 19-OM no- . ; — .     

Horizontal gene transfer from Eukarya to Bacteria and domain shuffling: the α-amylase model

-Amylases are present in all kingdoms of the living world. Despite strong conservation of the tertiary structure, only a few amino acids are conserved in interkingdom comparisons. Animal -amylases are characterized by several typical motifs and biochemical properties. A few cases of such -amylases have been previously reported in some eubacterial species. We screened the bacterial genomes available in the sequence databases for new occurrences of animal-like -amylases. Three novel cases were found, which belong to unrelated bacterial phyla: Chloroflexus aurantiacus, Microbulbifer degradans, and Thermobifida fusca. All the animal-like -amylases in Bacteria probably result from repeated horizontal gene transfer from animals. The M. degradans genome also contains bacterial-type and plant-type -amylases in addition to the animal-type one. Thus, this species exhibits -amylases of animal, plant, and bacterial origins. Moreover, the similarities in the extra C-terminal domains (different from both the -amylase domain C and the starch-binding domain), when present, also suggest interkingdom as well as intragenomic shuffling.Received 17 October 2003; accepted 6 November 2003     

Mutual replaceability of amide and ester groups in biologically active peptides and depsipeptides

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Study of neurosecretory cells ofHelix pomatia by intracellular dye injection

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A study of the mechanism of polymyxin M inactivation

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Association of viral ribonucleoprotein with polysomes

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The effect of protein biosynthesis inhibitors upon the development of cellular membranes hyperpolarization

( , , ) .     

Effect of some monoamine oxidase inhibitors on deamination of biogenic monoamines by rat liver mitochondrial monoamine oxidase

N--N- MAO , , .     

A new synthetic method of coumestan derivatives

Zusammenfassung Die Synthese von 7-Hydroxy-5,6-dimethoxybenzofurano[3,2:3,4]coumarin aus 7,2-Dihydroxy-oder 7-Benzyloxy-2-hydroxy-4,5-dimethoxyisoflavon wird beschrieben.     

Antihypertensive effect of Co-factors of the synthesis and precursors of nucleic acids in experimental hypertension

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Real-time models of morphogenetic processes

Summary Morphological transformations are often describable by simple series kinetic models,AB, ABC, etc., which allow assessment of the rates of interconversion of the distinguishable shapes or forms present and their probabilities of occurrence at various points in time, thus providing a means for kinetic comparisons with biochemical measurements of the molecular-level reactions that cause the transformations. When changes in cell morphology are followed turbidimetrically, the real-time progress curves can be simulated by fitting the data to a form of Beer's law for scattering by mixtures in which the species concentrations change with time in accordance with the chosen kinetic scheme. Because many even relatively large cells are mostly water, classical light scattering theory can be used to interpret the turbidimetric data in terms of simple geometrical models ofaverage cell size and shape suggested by microscopic examination. Two examples are briefly considered, the stimulus-induced changes in blood platelet shape and apparent size and their correlation with cytosolic-free calcium, and apparent swimming motion exhibited by neutrophils in suspension.What do you know about this business? the King said to Alice. Nothing, said Alice. Nothing whatever? persisted the King. Nothing whatever, said Alice. That's very important, the King said. Lewis Carroll (1865), in Alice's Adventures in Wonderland     

Chromosomes and giemsa-bands of the Idaho spotted ground squirrel,Spermophilus brunneus (Howell)

-Spermophilus brunneus . , 13 18 ,S. brunneus S. townsendii mollis (2n=38) , , ; ;S. brunneus . S. brunneus , Spermophilus.

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Supported by National Science Foundation Grants No. GB32114X and No. GB 29131X, and the Sprague Foundation. We thankD. Pozin for technical assistance.     

Synthesis and pharmacological properties of [1-N4-dimethyl-asparagine]-angiotensin II

Summary [1-N⁴-Dimethyl-asparagine]-angiotensin II was synthesized by Merrifield's solid-phase procedure. The analogue gave rat blood pressure about 70% relative potency to Hypertensin (Ciba). Rabbit aorta strips gave intrinsic activity _E=1, a PD₂ of 6.92±0.09 and an affinity relative to [Asn¹]-angiotensin II of 6.5%.The editors do not hold themselves responsible for the opinions expressed in the authors' brief reports. — Les auteurs sont seuls responsables des opinions exprimées dans ces brèves communications. — Für die Kurzmitteilungen ist ausschliesslich der Autor verantwortlich. — Per le brevi comunicazioni è responsabile solo l'autore. — . — Solo los autores son responsables de las opiniones expresadas en estas comunicationes breves.Acknowledgment. The authors wish to express their appreciation to Dr Emanuel Escher, School of Medicine, Centre Hospitalier Universitaire, Sherbrooke, Quebec, for his help in providing the biological data and critical comments.     

The role of the pentose-phosphate pathway in adjustment of the heart to a high load and the development of myocardial hypertrophy

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Contribution to the X-ray diffraction methods for precision determinations of polycrystal lattice parameters

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