Study of the mitotic activity during the preneoplastic period in the liver of rats treated by diethylnitrosamine (author's transl)]

The chronic administration of diethylnitrosamine in drinking water induces liver tumors in the rat. The preneoplastic period may be divided in two phases differing mainly in the loss of circadian control of mitotic activity in hepatocytes.     

Plurality in the determinism of organophosphorus teratogenic effects (author's transl)]

In Quail embryos, nicotinamide prevents beak and legs abnormalities produced by bidrin but remains inefficient against vertebral defects induced by bidrin and parathion. In contrast, the vertebral deficiencies are greatly alleviated or abolished by pralidoxim, an antidote known and used in organophosphorus intoxications. From these observations, a plurality in the determinism of teratogenic effects induced by organophosphorus compounds is evident.     

Antibiotically active tripeptides of the sequence L-arg-D-X-L-phe] (author's transl)]

Five tripeptides with the sequence L-Arg-D-X-L-Phe showed antibiotic activity on fungi and on some pathogenic moulds. The action of the peptides could be neutralized in the cross-strip test by the L-amino acid corresponding to the D-amino acid in the middle position.     

Microscopical investigations on the 'vessel sealing' effect of calcium ions (author's transl)]

The effect of locally applied calcium on the vascular permeability is studied under the conditions of an acute inflammatory reaction. Using the Sephadex-inflammation, local elevated calcium concentration neither inhibited oedema formation, nor were reduction of inflammatory signs at all observed on the microscopical level.     

Cholesterol 7alpha-hydroxylase activity of the rat liver after hypophysectomy and administration of hypophyseal hormones (author's transl)]

In order to elucidate the role of the hypophysis in the regulation of cholesterol 7alpha-hydroxylase activity, male and female rats hypophysectomized on day 50 of life were treated with different hypophyseal hormones and tested on day 85 of life. Only a crude extract from human hypophysis and ovine prolactin was able to enhance the enzyme activity, thereby restoring the level of intact controls.     

Autosomal chromosometranslocation of piebald cattle and brown cattle (author's transl)]

Different autosomal chromosome fusions at piebald cattle and brown cattle are described. In randomly investigated breeds of cattle in Germany, we found 1/25 translocation in piebald cattle and a 1/29 Robertsonian fusion in brown cattle. Fertility differences were investigated.     

Action of leucine aminopeptidase 1 and 2 (Aspergillus oryzae 410) on various synthetic peptides (author's transl)]

By use of di- or tripeptides as substrates, LAP 1 and LAP 2, 2 fractions from Aspergillus oryzae hydrolyze oligopeptides that possess leucine as N-terminal amino acid. LAP 1 fraction also hydrolyzes the histidyl bond. Both fractions have no activity towards peptides as glutathion, gly-pro-ala; they have low or no activity towards tyrosyl and tryptophanyl bond.     

Effect of Corynebacterium parvum on serum lysozyme (muramidase) levels (author's transl)]

An i.v. injection of 548 microgram of killed Corynebacterium parvum into C57B1 mice leads to significant changes in serum lysozyme (muramidase) levels. After an initial fall at 24 h, the activity of the enzyme increased progressively, reached a peak on the 9th day and returned to control range after the 15th day.     

Lipids in the egg shell of the ostrich (Struthio camelus) (author's transl)]

The egg shell (with cuticle) of the ostrich contained a total lipid concentration of 0.19 mg/g egg shell; the phospholipids constituted the major portion, among the neutral' lipids cholesterol esters, cholesterol and free fatty acids were identified. The egg shell lipids showed a stimulating effect on the crystal growth of calcium carbonate; the highest rate of crystal growth was observed with the phospholipid fraction.     

Effects of reserpine on development of Oedipoda coerulescens L. (Acrididae, Orthoptera) (author's transl)

Inhibitory effects of reserpine on ecdysis and chromatic adaptation in Oedipoda appear to be linked with changes observed in both neural and neuro-endocrine regulating systems.     

Phagocytic activity of the reticuloendothelial system in the rat after administration of an anticholinesterasic pesticide, carbaryl (author's transl)]

The effects of 4 carbaryl doses (0.375, 0.75, 1.50 and 3 mg/100 g) on the reticuloendothelial system (RES) phagocytic activity were studied 1 h after their administration to male rats. Carbaryl reduced RES phagocytic activity. Results showed a dose-dependent drop in RES phagocytic activity. Carbaryl might act as an inhibitor of phagocytes by saturing them to greater or lesser degree, depending on the dose administered.     

Induced radiation resistance in cell cultures of Chinese hamster cells: induction and manner of resistance (author's transl)]

Mutations-induction followed by selection is a suitable method for developing a cell line with resistance to low doses of X-rays. In comparison with the original cell line, the derived resistant line is characterized by an enhanced variability of the chromosome number, and no higher level of cellular repair, limited to the two repair types described.     

Early effects of growth hormone on blood and urinary inorganic phosphorus in the rat (author's transl)]

From the kinetic study of the effects of one single growth hormone (GH) injection on the phosphate metabolism, it appears that the influence of GH on the serum phosphate level is biphasic: a decrease is followed by an increase. Conversely GH leads to an early decrease of the urinary phosphate excretion.     

Effects of microdoses of testosterone and 5alpha-DHT on castrated lizard (Lacerta vivipara Jacquin) epididymis cultivated in vitro (author's transl)]

In contrast to earlier results obtained with high doses of testerone and 5 alpha-DHT given for short periods (10 days), very low doses of testerone are more potent than 5 alpha-DHT in stimulating regressed epididymis cultivated for 23 days.     

Morphological effects of concanavalin A on amphibian embryonic cells differentiating in vitro (author's transl)]

Concanavalin A exerts an irreversible inhibitory effect on the differentiation of cultured embryonic amphibians cells in vitro. Cytological changes and distrubances of cell attachment, and spreading to the culture support occur in parallel. Polykaryons have been noticed in treated cultures.     

Comparative study of the effect of thymosin and supernatant from epithelial thymic cells on antibody production (author's transl)]

A thymic extract (TE) was prepared from supernatant of mice thymic epithelial cultures according to the purification of thymosin. TE and thymosin stimulated, in vitro, the immune response of mouse against deep red blood cells.