基于光电容积脉搏波的无创血糖测量研究

目前临床使用的血糖测量方法是采用直接抽取患者血液, 根据生物化学反应原理测量血糖, 这种有创测量方法存在疼痛、易感染、不能连续测量等问题。根据光电容积脉搏波检测理论, 研究了一种血糖测量方法,实现临床无创连续血糖测量。该方法采用波长为805 nm 和940 nm 两束近红外光透射患者手指, 其中805 nm为血糖敏感波长, 940 nm 为参考波长。从透射光中提取与血糖有关的信息进行数据处理并进行标定, 计算血糖值。经实验验证, 该方法能实现连续的无创血糖测量。     

光谱分析用于无创血糖检测的微量葡萄糖测量

采用无创伤的方法检测血糖是人们长期以来追求的目标,是当今国际医疗和传感器领域十分关注的课题之一.无创血糖检测将使糖尿病检测手段产生质的飞跃,对糖尿病的治疗具有重要的实际意义.唾液中葡萄糖含量仅为血液中葡萄糖含量的1 50～1 100,所以通过人的唾液测量血糖值,其精度要达到0.01mmol L.基于光谱分析技术,实现了葡萄糖的微量检测,精度高,重复性好.为实现无创血糖检测奠定了良好的基础.     

小波变换和能谱分析在无损血糖检测中的应用

提出并通过实验验证了一种新型无创血糖检测方法. 该方法以人体耳垂作为目标检测组织,以高频正弦信号作为检测信号,实验以不同浓度的葡萄糖溶液代替不同血糖浓度的血液,根据接收信号的差异来反映人体血糖浓度的变化,从而实现无创检测人体血糖浓度的目的. 对接收信号进行小波变换和能谱分析,运用小波变换对接收信号进行降噪处理,并从能量密度谱的角度分析不同血糖浓度下接收信号的差异.     

基于超声调制光信号技术无创检查葡萄糖浓度

糖尿病是一种多发常见病,不能根治却能很好控制。如果能够有精确、快速、无损的检测方法,需要时就能监测血糖浓度,这将为糖尿病的治疗带来革命性的进步。超声调制的光学检测方法是新兴的且很有发展前景的无损诊断技术,本文通过实验研究超声调制的光学信号与浑浊介质中葡萄糖浓度的关系,实验的初步结果表明,超声调制的光学信号可以灵敏地测量出浑浊介质中葡萄糖浓度的微小变化,且在吸收介质中比在散射介质中,超声调制光学信号对葡萄糖浓度的变化更灵敏。这为该方法应用在血糖的无创检测提供了可能性。     

一种连续无创血压监测头带的研究

目前大多数无创血压测量采用的是袖带示波测量法,仪器携带不方便;通过气泵对袖带进行充放气,测量周期长,不能够对人体血压进行连续地测量,考虑研制穿戴式血压测量头带,对人体血压进行无创连续测量.采用高分辨率心电采集芯片ADS1292R采集头部微弱心电信号(electrocardiogram,ECG),同时使用反射式光电传感器在眉骨处采集时间上严格同步的光电容积脉搏波信号(photoplethysmography,PPG).分别定位ECG和PPG的特征点,计算PPG信号传播延迟(pulse wave transit time,PWTT),并和同一时刻血压值进行相关性分析以及回归分析,建立血压测量模型,即可根据PWTT求得血压.对试验者进行实验表明,采用该便携式无创血压检测装置与传统无创血压测量法对比,误差维持在5％以内.该检测头带信号采集均在头部完成,穿戴方便,功耗低,舒适性强,是一种可行的便携无创连续血压监测装置;同时可将检测结果通过蓝牙实时传至用户手机或PDA装置显示并存储,完成长时间动态血压监护.     

基于动态光谱的血糖无创检测中有效信号的提取与建模方法研究

为提升无创检测的准确度,本文在动态光谱检测预处理方法中应用了新的信号提取方法,对接对数脉搏波的所有上升沿与下降沿,筛选有效沿,剔除粗大误差,提高了信噪比,消除了频谱重叠现象.在建模方法上,采用主成分分析方法对多样本的动态光谱值矩阵实现降维处理,采用GA与BP神经网络相结合取长补短的方法建立最终的数学模型,实现血液成分浓度预测的目的.实验表明,该方法能够提高血糖检测的准确度,有利于动态光谱在血糖无创检测方面的发展.     

光学无创血糖检测中的主要问题及研究进展

分析了目前困扰人体血糖无创测量的瓶颈问题，针对信号特异性差、生理背景干扰严重的现实，提出了利用光强对葡萄糖浓度变化不敏感的基准点和光强灵敏度最大的测量点进行同时测量的浮动基准点检测方法，并论证了基准点存在的条件和通过基准点的信息消除生理背景噪声的可能性，最后通过初步的实验验证了基于浮动基准点的方法能有效消除背景噪声对糖信息的影响．     

颅内血肿和水肿的无创检测方法

分析了颅内血肿和水肿测量的现状及无创检测方法的意义,提出一种无创检测的新方法．根据涡流感应原理,将外部激励磁场作用于大脑,在颅内脑质中感应出涡流,通过测量该涡流激发的二次磁场的强弱来反映颅内血肿和水肿的情况．详细分析了无创检测方法的电磁场理论基础,开发出实验测量系统,并对测量系统的关键模块做了简要介绍．通过模拟水槽实验,证明该方法是可行的．分析了现有系统的不足之处,并提出了改进方案．     

基于LabVIEW的无创脉搏血氧检测系统设计

设计了一种无创光电容积脉搏波检测系统,它借助LabVIEW图形化虚拟仪器开发平台,利用LabVIEW产生时序信号,调制夹指传感嚣拾取的光电容积脉搏波.通过前置放大滤波及信号调理电路,然后采集脉搏波.经过基于LabVIEW的数字锁相技术,最终解调获得光电容积脉搏波信号.实验结果表明,该系统可以实现无创脉搏波实时检测、脉搏波形回放、储存和分析等功能.     

无创血糖检测方法的研究

对血糖浓度进行紧密控制能减少或减轻糖尿病病人的长期并发症,糖尿病病人在诊疗期间经常要进行血糖浓度化验,频繁进行的抽血给病人带来了痛苦和不便,也给医护人员增添了工作.为了改变这一局面,近年来国内外正在积极研究血糖浓度的无创性检测方法.本文对多种葡萄糖无创检测方法(如傅立叶变换红外光谱法,组织的力学操作,脉冲光声技术等)进行了研究和总结.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

An affordable accurate evaluation of the binding conformations predicted by molecular docking studies in bio-system

Franck-Condon factors bridge the gap between theoretical modeling and experimental observations for molecular electronic spectroscopy and electron transfer.Under the displaced harmonic oscillator approximation,multidimensional Franck-Condon factors are decomposed into a product of many one-dimensional(1D)Franck-Condon(FC)factors,and each 1D-FC factor is associated with one Huang-Rhys factor that determines the leading contribution of     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with     

Journal of Donghua University ( English Edition) Contents of Volume 31

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