Early eighteenth-century Newtonianism: the Huguenot contribution

John Theophilus Desaguliers’s allegorical poem The Newtonian system of the world, the best model of government (1728) crystallizes the contribution of several important French Protestant exiles to the construction of early Newtonianism. In the context of diverging interpretations of Newton’s scientific achievement in terms of natural religion, writers such as Des Maizeaux, Coste, Le Clerc and others actively disseminated a version of Newtonianism which was close to Newton’s own intention. Through public experiments, translations, correspondence, reviews and books, they managed to convey a vision of Newtonian science which coincided with their propaganda of English liberties in Church and State. Therefore their effort on behalf of Newtonianism can be interpreted as part of a wider strategy of assimilation into English society at a time when most exiled Huguenots had given up hope of ever recreating a French Reformed Church at home.     

Newtonianism and the enthusiasm of Enlightenment

The career of John Jackson (1686-1763), Arian theologian and controversialist, provides a key to unlocking the early reception and quick collapse of a Newtonian natural apologetic originally developed by Samuel Clarke. The importance of friendship and discipleship in eighteenth-century intellectual enquiry is emphasised, and the links between Newton and his followers are traced alongside those of a group of Cambridge Lockeans, led by Jackson’s direct contemporary Daniel Waterland, who proved instrumental in the initial dismantling of Clarke’s brand of Newtonian apologetic. The controversial context of this engagement is shown to have been largely provided by the religiously compromising rise of freethinking, and Tindal’s Christianity as old as the creation (1731) signalled the dangers to proponents of natural religion as an adjunct of Christian apologetic in such a heated atmosphere. Religious division of the sort that resulted paradoxically played into the hands of the freethinkers in the anticlerical atmosphere of the 1730s, and accusations were exchanged between Newtonians and Lockeans accordingly. The dynamic of England’s Enlightenment experience is, then, a complicated one, and, as the career and writings of Jackson and William Whiston demonstrate, it was one which absorbed as well as repudiated ‘enthusiasm’.     

Newtonianism in early Enlightenment Germany, c. 1720 to 1750: metaphysics and the critique of dogmatic philosophy

The acceptance of Newton’s ideas and Newtonianism in the early German Enlightenment is usually described as hesitant and slow. Two reasons help to explain this phenomenon. One is that those who might have adopted Newtonian arguments were critics of Wolffianism. These critics, however, drew on indigenous currents of thought, pre-dating the reception of Newton in Germany and independent of Newtonian science. The other reason is that the controversies between Wolffians and their critics focused on metaphysics. Newton’s reputation, however, was that of a mathematician, and one point, on which Wolffians and their opponents agreed, was that mathematics was of no use in the solution of metaphysical questions. The appeal to Newton as an authority in metaphysics, it was argued, was the fault of Newton’s over-zealous disciples in Britain, who tried to transform him from a mathematician into the author of a general philosophical system. It is often argued that the Berlin Academy after 1743 included a Newtonian group, but even there the reception of Newtonianism was selective. Philosophers such as Leonhard Euler were also reluctant to be labelled ‘Newtonians’, because this implied a dogmatic belief in Newton’s ideas. Only after the mid-eighteenth century is ‘Newtonianism’ increasingly accepted in the sense of a philosophical system.     

Associationism without associative links: Thomas Brown and the associationist project

There are two roles that association played in 18th–19th century associationism. The first dominates modern understanding of the history of the concept: association is a causal link posited to explain why ideas come in the sequence they do. The second has been ignored: association is merely regularity in the trains of thought, and the target of explanation. The view of association as regularity arose in several forms throughout the tradition, but Thomas Brown (1778–1820) makes the distinction explicit. He argues that there is no associative link, and association is mere sequence. I trace this view of association through the tradition, and consider its implications: Brown's views, in particular, motivate a rethinking of the associationist tradition in psychology. Associationism was a project united by a shared explanandum phenomenon, rather than a theory united by a shared theoretical posit.     

Signs, toy models, and the a priori: from Helmholtz to Wittgenstein

The Marburg neo-Kantians argue that Hermann von Helmholtz’s empiricist account of the a priori does not account for certain knowledge, since it is based on a psychological phenomenon, trust in the regularities of nature. They argue that Helmholtz’s account raises the ‘problem of validity’ (Gültigkeitsproblem): how to establish a warranted claim that observed regularities are based on actual relations. I reconstruct Heinrich Hertz’s and Ludwig Wittgenstein’s Bild theoretic answer to the problem of validity: that scientists and philosophers can depict the necessary a priori constraints on states of affairs in a given system, and can establish whether these relations are actual relations in nature. The analysis of necessity within a system is a lasting contribution of the Bild theory. However, Hertz and Wittgenstein argue that the logical and mathematical sentences of a Bild are rules, tools for constructing relations, and the rules themselves are meaningless outside the theory. Carnap revises the argument for validity by attempting to give semantic rules for translation between frameworks. Russell and Quine object that pragmatics better accounts for the role of a priori reasoning in translating between frameworks. The conclusion of the tale, then, is a partial vindication of Helmholtz’s original account.     

Newton’s substance monism, distant action, and the nature of Newton’s empiricism: discussion of H. Kochiras “Gravity and Newton’s substance counting problem”

This paper is a critical response to Hylarie Kochiras’ “Gravity and Newton’s substance counting problem,” Studies in History and Philosophy of Science 40 (2009) 267-280. First, the paper argues that Kochiras conflates substances and beings; it proceeds to show that Newton is a substance monist. The paper argues that on methodological grounds Newton has adequate resources to respond to the metaphysical problems diagnosed by Kochiras. Second, the paper argues against the claim that Newton is committed to two speculative doctrines attributed to him by Kochiras and earlier Andrew Janiak: i) the passivity of matter and ii) the principle of local causation. Third, the paper argues that while Kochiras’ (and Janiak’s) arguments about Newton’s metaphysical commitments are mistaken, it qualifies the characterization of Newton as an extreme empiricist as defended by Howard Stein and Rob DiSalle. In particular, the paper shows that Newton’s empiricism was an intellectual and developmental achievement that built on non trivial speculative commitments about the nature of matter and space.     

Gravity’s cause and substance counting: contextualizing the problems

This paper considers Newton’s position on gravity’s cause, both conceptually and historically. With respect to the historical question, I argue that while Newton entertained various hypotheses about gravity’s cause, he never endorsed any of them, and in particular, his lack of confidence in the hypothesis of robust and unmediated distant action by matter is explained by an inclination toward certain metaphysical principles. The conceptual problem about gravity’s cause, which I identified earlier along with a deeper problem about individuating substances, is that a decisive conclusion is impossible unless certain speculative aspects of his empiricism are abandoned. In this paper, I situate those conceptual problems in Newton’s natural philosophy. They arise from ideas that push empiricism to potentially self-defeating limits, revealing the danger of allowing immaterial spirits any place in natural philosophy, especially spatially extended spirits supposed capable of co-occupying place with material bodies. Yet because their source ideas are speculative, Newton’s method ensures that these problems pose no threat to his rational mechanics or the profitable core of his empiricism. They are easily avoided by avoiding their source ideas, and when science emerges from natural philosophy, it does so with an ontology unencumbered by immaterial spirits.     

Publishing and the classics: Paley’s Natural theology and the nineteenth-century scientific canon

This article seeks a new way to conceptualise the ‘classic’ work in the history of science, and suggests that the use of publishing history might help avoid the antagonism which surrounded the literary canon wars. It concentrates on the widely acknowledged concept that the key to the classic work is the fact of its being read over a prolonged period of time. Continued reading implies that a work is able to remain relevant to later generations of readers, and, although some of this depends upon the openness of the original text, much more depends on the actions of subsequent publishers and editors in repackaging the work for later audiences.This is illustrated through an examination of the long publishing history of William Paley’s Natural theology (1802). Over the course of the century, Natural theology was read as a work of gentlemanly natural theology, as a work which could be used in a formal or informal education in science, and as a work of Christian apologetic. These transformations occurred because of the actions of the later publishers and editors who had to make the work suit the current interests of the literary marketplace. Comparisons are made to Constitution of man, Vestiges of the natural history of creation and Origin of species.     

Emilie du Châtelet’s Institutions de physique as a document in the history of French Newtonianism

This paper discusses the contribution of Madame Du Châtelet to the reception of Newtonianism in France prior to her translation of Newton’s Principia. It focuses on her Institutions de physique, a work normally considered for its contribution to the reception of Leibniz in France. By comparing the different editions of the Institutions, I argue that her interest in Newton antedated her interest in Leibniz, and that she did not see Leibniz’s metaphysics as incompatible with Newtonian science. Her Newtonianism can be seen to be in the course of development between 1738 and 1742 and it was shaped by contemporary French debates (for example the vis viva controversy) and the achievement of French Newtonians like Maupertuis in confirming his theories. Her Institutions therefore is linked to the same drive to disseminate Newtonianism undertaken by popularisations such as Voltaire’s Elements de la philosophie de Newton and Algarotti’s Newtonianismo per le dame.     

The material theory of induction and the epistemology of thought experiments

John D. Norton is responsible for a number of influential views in contemporary philosophy of science. This paper will discuss two of them. The material theory of induction claims that inductive arguments are ultimately justified by their material features, not their formal features. Thus, while a deductive argument can be valid irrespective of the content of the propositions that make up the argument, an inductive argument about, say, apples, will be justified (or not) depending on facts about apples. The argument view of thought experiments claims that thought experiments are arguments, and that they function epistemically however arguments do. These two views have generated a great deal of discussion, although there hasn't been much written about their combination. I argue that despite some interesting harmonies, there is a serious tension between them. I consider several options for easing this tension, before suggesting a set of changes to the argument view that I take to be consistent with Norton's fundamental philosophical commitments, and which retain what seems intuitively correct about the argument view. These changes require that we move away from a unitary epistemology of thought experiments and towards a more pluralist position.     

Explaining Leibniz equivalence as difference of non-inertial appearances: Dis-solution of the Hole Argument and physical individuation of point-events

“The last remnant of physical objectivity of space–time” is disclosed in the case of a continuous family of spatially non-compact models of general relativity (GR). The physical individuation of point-events is furnished by the autonomous degrees of freedom of the gravitational field (viz., the Dirac observables) which represent—as it were—the ontic part of the metric field. The physical role of the epistemic part (viz. the gauge variables) is likewise clarified as embodying the unavoidable non-inertial aspects of GR. At the end the philosophical import of the Hole Argument is substantially weakened and in fact the Argument itself dissolved, while a specific four-dimensional holistic and structuralist view of space–time (called point-structuralism) emerges, including elements common to the tradition of both substantivalism and relationism. The observables of our models undergo real temporal change: this gives new evidence to the fact that statements like the frozen-time character of evolution, as other ontological claims about GR, are model dependent.     

‘The long-lost truth’: Sir Isaac Newton and the Newtonian pursuit of ancient knowledge

In the 1720s the antiquary and Newtonian scholar Dr. William Stukeley (1687-1765) described his friend Isaac Newton as ‘the Great Restorer of True Philosophy’. Newton himself in his posthumously published Observations upon the prophecies of Daniel, and the Apocalypse of St. John (1733) predicted that the imminent fulfilment of Scripture prophecy would see ‘a recovery and re-establishment of the long-lost truth’. In this paper I examine the background to Newton’s interest in ancient philosophy and theology, and how it related to modern natural philosophical discovery. I look at the way in which the idea of a ‘long-lost truth’ interested others within Newton’s immediate circle, and in particular how it was carried forward by Stukeley’s researches into ancient British antiquities. I show how an interest in and respect for ancient philosophical knowledge remained strong within the first half of the eighteenth century.     

The impact of forecasting methodology on the accuracy of national population forecasts: evidence from the Netherlands and Czechoslovakia

"This study considers the accuracy of national population forecasts of the Netherlands and the Czechoslovak Socialist Republic.... We look at the demographic components employed in each forecast, the procedure to extrapolate fertility and the level at which assumptions for each component are formulated. Errors in total population size, fertility, mortality and foreign migration, and age structure are considered. We discuss trends in errors and methodology since 1950 and compare the situations in the two countries. The findings suggest that methodology has only a very limited impact on the accuracy of national population forecasts."     

Lanthanide-binding peptides and the enzymes that Might Have Been

The trivalent lanthanide ions are chemically similar to Ca(II) ions, making them useful Ca analogs for a multitude of applications. In addition, Ln(III) ions are efficient catalysts of hydrolysis due to their much stronger Lewis acidity relative to Ca(II) ions. Ln-binding peptides thus offer both the opportunity to study known Ca sites as well as to explore new biological functions with an entire family of spectroscopically rich and reactive ions. This review discusses Ln-binding peptides in three roles: (i) as models of Ca-protein structure and function, (ii) as spectroscopic tags for protein expression and characterization and (iii) as designed artificial endonucleases. The creation of hydrolytically active Ln peptides that can fold, bind, cleave and discriminate among substrates shows that the design of Ln enzymes can be accomplished, and they will serve as versatile biochemical tools to investigate protein folding, structure and nuclease function.Received 10 April 2004; received after revision 17 May 2004; accepted 28 May 2004     

天宫一号目标飞行器载人环境设计与实施

基于天宫一号目标飞行器载人环境控制任务的新特点,以航天员的"舒适性"为设计目标,天宫一号进行了大气环境控制设计、噪声控制设计、辐射控制设计以及组合体热支持设计等载人环境设计,将组合体密封舱内的大气总压、温湿度、风速、气体成分、噪声以及辐射水平控制在人体舒适性范围内,天宫一号飞行任务表明,其载人环境系统设计正确,为飞行任务期间航天员的身体健康和工作效率提供有力保障.     

应急系统中数据收集与库设计

介绍应急系统中数据库设计思想、方法;分析了应急系统中所需的数据信息以及开发该应急系统所应建立的数据库;同时,还研究了应急系统中各数据库的相应属性及数据库之间所存在的联系。其目的是为了更好的收集、整理、共享处理应急突发事件时所需的各种数据信息,并将其以库的形式存储起来,为应急指挥部提供准确、具体的信息,为快速响应、协调行动提供信息基础。     

基于开放式的错误处理机制的设计与实现

本文探讨了软件项目中错误处理机制的作用及应用需求,结合软件项目开发中的实践经验,利用XML进行配置和描述,巧妙地设计与实现了一种通用的,基于开放式的错误处理机制,该机制配置灵活、操作方便、通用性好.     

Case study research in the social sciences

In this paper, we offer an introduction to case study research in the social sciences. We begin with a discussion of the definition of case study research. Next, we point to various purposes that case study research may serve in the social sciences and then turn to outline the main philosophical issues raised by case study research. Finally, we briefly present the papers in this special issue.     

Selectivity determinants of the aldose and aldehyde reductase inhibitor-binding sites

Aldose reductase and aldehyde reductase belong to the aldo-keto reductase superfamily of enzymes whose members are responsible for a wide variety of biological functions. Aldose reductase has been identified as the first enzyme involved in the polyol pathway of glucose metabolism which converts glucose into sorbitol. Glucose over-utilization through the polyol pathway has been linked to tissue-based pathologies associated with diabetes complications, which make the development of a potent aldose reductase inhibitor an obvious and attractive strategy to prevent or delay the onset and progression of the complications. Structural studies of aldose reductase and the homologous aldehyde reductase in complex with inhibitor were carried out to explain the difference in the potency of enzyme inhibition. The aim of this review is to provide a comprehensive summary of previous studies to aid the development of aldose reductase inhibitors that may have less toxicity problems than the currently available ones. Received 4 December 2006; received after revision 12 February 2007; accepted 20 April 2007