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Antisense transcription: A critical look in both directions 总被引:3,自引:1,他引:2
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RNA-mediated gene silencing 总被引:21,自引:0,他引:21
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Pascale Romby Emmanuelle Charpentier 《Cellular and molecular life sciences : CMLS》2010,67(2):217-237
During the last decade, RNA molecules with regulatory functions on gene expression have benefited from a renewed interest.
In bacteria, recent high throughput computational and experimental approaches have led to the discovery that 10–20% of all
genes code for RNAs with critical regulatory roles in metabolic, physiological and pathogenic processes. The trans-acting RNAs comprise the noncoding RNAs, RNAs with a short open reading frame and antisense RNAs. Many of these RNAs act
through binding to their target mRNAs while others modulate protein activity or target DNA. The cis-acting RNAs include regulatory regions of mRNAs that can respond to various signals. These RNAs often provide the missing
link between sensing changing conditions in the environment and fine-tuning the subsequent biological responses. Information
on their various functions and modes of action has been well documented for gram-negative bacteria. Here, we summarize the
current knowledge of regulatory RNAs in gram-positive bacteria. 相似文献
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