共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
Recent advances in androgen receptor action 总被引:17,自引:0,他引:17
5.
The mammalian sex-determining gene, SRY, was identified by positional cloning approximately 10 years ago. Since its discovery, intense research into this gene has been directed on two main fronts: elucidation of its function in development of the testis and examination of its singular evolutionary history. The role or SRY as the testis-determining factor (TDF) places it at a crucial point in the highly conserved morphogenetic process of vertebrate gonadogenesis. None of the genes that directly activate SRY nor any of its immediate downstream targets have yet been positively identified. Several genes, however, such as SF1, DAX1, and SOX9, whose spatial and temporal expression profiles overlap with that of SRY, are strongly implicated as co-regulators of gonadogenesis. Molecular genetic manipulation of these genes in mice has shown that they are indispensable to sexual development. Remarkably, its key position in this cascade of gene action has not protected SRY from strong yet poorly understood selective forces that have caused it to evolve rapidly in mammals. The evolution of SRY has been characterized not only by rapid sequence divergence within mammals, but also by structural changes such as intron insertion, gene amplification, and deletion. 相似文献
6.
The one-to-four rule and paralogues of sex-determining genes 总被引:5,自引:0,他引:5
S. Ohno 《Cellular and molecular life sciences : CMLS》1999,55(6-7):824-830
7.
C. Pieau M. Dorizzi N. Richard-Mercier 《Cellular and molecular life sciences : CMLS》1999,55(6-7):887-900
8.
Calcium regulation of the brain-derived neurotrophic factor gene 总被引:13,自引:0,他引:13
Finkbeiner S 《Cellular and molecular life sciences : CMLS》2000,57(3):394-401
9.
10.
11.
Functional analysis of the human MCL-1 gene 总被引:6,自引:0,他引:6
Akgul C Turner PC White MR Edwards SW 《Cellular and molecular life sciences : CMLS》2000,57(4):684-691
12.
DNA methylation and the regulation of gene transcription 总被引:28,自引:0,他引:28
13.
DAX-1, an ‘antitestis’gene 总被引:2,自引:0,他引:2
14.
15.
The morphological development of the embryonic gonads is very similar in birds and mammals, and recent evidence suggests
that the genes involved in this process are conserved between these classes of vertebrates. The genetic mechanism by which
sex is determined in birds remains to be elucidated, although recent studies have reinforced the contention that steroids
may play an important role in the structural development of the testes and ovaries in birds. So far, few genes have been assigned
to the avian sex chromosomes, but it is known that the Z and W chromosomes do not share significant homology with the mammalian
X and Y chromosomes. The commercial importance of poultry breeding has motivated considerable investment in developing physical
and genetic maps of the chicken genome. These efforts, in combination with modern molecular approaches to analyzing gene expression,
should help to elucidate the sex-determining mechanism in birds in the near future. 相似文献
16.
17.
Activation of immediate early genes and memory formation 总被引:14,自引:0,他引:14
18.
Biological functions of the ING family tumor suppressors 总被引:11,自引:0,他引:11
19.
20.
Grimm DR Colter MB Braunschweig M Alexander LJ Neame PJ Kim HK 《Cellular and molecular life sciences : CMLS》2001,58(1):148-159
Factor V is a plasma protein essential for blood coagulation. This protein is involved in activated protein C resistance,
the most common inherited thrombotic disorder known. We utilized the polymerase chain reaction to clone the porcine factor
V gene by generating overlapping clones amplified with primers chosen by comparison with known nucleotide sequences. The porcine
factor V cDNA contig encodes a predicted 2258-amino acid protein, making it the largest in comparison to the bovine, human,
and murine proteins. Porcine factor V has the highest level of homology with bovine factor V, but also has high levels of
conservation of important residues with all the species. Radiation hybrid mapping assigned the porcine factor V gene to chromosome
4. Three-dimensional models of factor V were generated and used to analyze membrane-binding sites in terms of conserved, and
therefore likely important residues.
Received 3 October 2000; revised 23 November 2000; accepted 6 December 2000 相似文献