The prevention of experimentally induced reticulo-sarcoma by hypothyroidism

Zusammenfassung Die Entstehung von Reticulosarkom bei Ratten nach mehrmaliger Injektion von Trypanblau kann unterdrückt werden durch Entkräftung, Verabreichung anti-thyreoidaler Mittel und durch alle andern Faktoren, welche den Stoffwechsel herabsetzen.     

Connective tissue reactions in experimentally induced hypertension

Zusammenfassung Histologische Untersuchungen verschiedener Gefässgebiete von renal hypertonischen Ratten zeigten keine Abhängigkeit der Gefäßschäden vom Verlauf des Hochdruckes. Typische Gefässveränderungen für den experimentellen Hochdruck sind auch bei solchen Tieren zu finden, deren systolischer Druck trotz Einengen einer Nierenarterie nicht signifikant anstieg. Die Bindegewebsreaktion gegenüber einem Fremdkörper wird gesteigert. Es wird unterschieden zwischen Faktoren, die für die Hochdruckentstehung, und solchen, die für eine Umstimmung des Mesenchyms verantwortlich sind. Beide Prozesse können methodisch gleichartig ausgelöst werden. Es sind sexualspezifische Unterschiede vorhanden, da im allgemeinen Weibchen zu einer verstärkten Blutdruckreaktion, Männchen dagegen zu vermehrten Gefäßschädigungen neigen, besonders zu sklerotischen Veränderungen. Bei Klammerung einer Nierenarterie führt die gleichzeitige Exstirpation der zweiten Niere zu einer Änderung des Hochdrucks in qualitativer Hinsicht.

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Dedicated to ProfessorRolf Meier on the occasion of his 60th birthday.     

Imbalance in the activities of alkaline phosphatase and Na+-K+-ATPase in the brain of experimentally induced phenylketonuric squirrels (Funambulus palmarum)

Summary Phenylketonuric squirrels have shown marked inhibition of alkaline phosphatatase in the olfactory lobes and cerebral hemispheres, whereas the Na⁺-K⁺-ATPase remained less altered. In the pathogenesis of phenylketonuria inhibition of alkaline phosphatase at the level of Blood-Brain Barrier (BBB), leads transport system to impaired functioning.This work was done in the Department of Zoology, University of Udaipur, Udaipur-313001, India.     

Imbalance in the activities of alkaline phosphatase and Na+-K+-ATPase in the brain of experimentally induced phenylketonuric squirrels (Funambulus palmarum).

Phenylketonuric squirrels have shown marked inhibition of alkaline phosphatase in the olfactory lobes and cerebral hemispheres, whereas the Na+-K+-ATPase remained less altered. In the pathogenesis of phenylketonuria inhibition of alkaline phosphatase at the level of "Blood-Brain Barrier" (BBB), leads transport system to impaired functioning.     

Amniotic fluid volume in experimentally induced renal agenesis and anencephaly

Zusammenfassung Experimentelle Prüfung beim Goldhamster,Mesocricetus auratus, ob Nieren- oder Gehirnmissbildungen einen Einfluss auf die Quantität der Amnionflüssigkeit ausüben, was nur für die Gehirnmissbildungen bejaht werden konnte.

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This work was supported by research grants from the Easter Seal Research Foundation of the National Society for Crippled Children and Adults, Inc. and from USPHS grant No. HD 03298.     

Progressive impairment in high energy phosphate pattern induced by intermittent coronary perfusion

Summary After continuous myocardial ischemia, ATP and CP are both depressed. A different pattern is exhibited in the course of intermittent coronary perfusion. The drop in ATP stores is not avoided, but progressive resis in CP contents is observed.Acknowledgments. The authors are grateful to Mrs G. Boulot and Miss Bidault for excellent technical assistance.     

Altered adrenergic responses of the coronary arterial bed in alloxan-diabetic dogs

Summary The conductivity of the coronary arterial bed increased in healthy and decreased in alloxan-diabetic dogs in response to intracoronary administration of norepinephrine or sympathetic stimulation. This suggests a modification of adrenergic receptors sensitivity in diabetes.     

Impaired metabolism of arachidonate in selenium deficient animals

Cellular and Molecular Life Sciences - Arachidonate-induced respiratory distress in mice was aggravated in a selenium deficient group as compared with a selenium supplemented one. The aggravation...     

Structural relationships between the endogenous volatile urinary metabolites of experimentally diabetic rats and certain neurotoxins

Summary High resolution glass capillary gas chromatography and GC/MS were utilized to examine qualitative and quantitative variations from normal of urinary volatile metabolites of long-term alloxan and streptozotocin diabetic rats. Volatile metabolites were structurally compared with known neurotoxins to examine any possible relationship between these metabolites and the development of the diabetic polyneuropathy.Acknowledgment. This research was supported by grant No. 24349 from the National Institute of General Medical Sciences, U.S. Public Health Service.     

Streptozotocin induced diabetic nephropathy and renal tumors in the rat

Summary Adult Wistar rats rendered diabetic by a single dose of streptozotocin develop renal morphological changes which show subtle differences compared to those seen in human diabetic renal disease. The early tubular degeneration is sited in the distal rather than the proximal convoluted tubule and subsequent glomerular lesion shows linear deposits of IgG and albumin in the basement membrane rather than in the mesangium. The carcinogenicity of streptozotocin in the rat is reconfirmed.Acknowledgements. We wish to thank Mr S.G. Watkins and Mrs D. Greening for technical assistance.