Responses of isolated blood vessels to acetylcholine,epinephrine, norepinephrine,and histamine

Zusammenfassung Acetylcholin verursachte in den Coronar-, Femoral- und Mesenterialarterien, Catecholamine in den Femoral- und Mesenterialgefässen Konstriktionen, in den Coronargefässen hingegen Dilatation.

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This work was completed in the Department of Physiology, University of Mississippi Medical Center, Jackson (Mississippi USA).     

Die Zucht vonLytta vesicatoria im Laboratorium und Nachweis der Cantharidinsynthese in Larven

Summary Adult males ofLytta vesicatoria (Coleopt., Meloidae) synthesize cantharidin, but females do not, although the substance is present in the females too. We developed a method for rearing larvae of this parasitic beetle in the laboratory. It is shown that there exist 7 larval stages and 4 hypermetamorphic forms (triungulinus, second larva,pseudochrysalis and fourth larva). Larvae from the second to the fifth stage (second larva) synthesize cantharidin. Therefore, we conclude that the substance present in the adult female is at least in part synthesized in the larval period. Nothing is known about the biological significance of this biochemical sexual dimorphism.

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Coleoptera, Meloidae.     

Nachweis von Scilliglaucosidin in den Zwiebeln vonBowiea volubilis Harvey

Summary Hellebrigenin was converted to Scilliglaucosidin-19-ol and 3-Epi-Scilliglaucosidin-19-ol. This proves the correctness of the assumption ofStoll et al. ³ that the aldehydic group of Scilliglaucosidin is in position C-10.Comparison of a reduction product of Nabogenin, a substance isolated earlier from the bulbs ofBowiea volubilis Harvey, with Scilliglaucosidin-19-ol and 3-Epi-Scilliglaucosidin-19-ol showed its identity with the first named compound. This proves that the so called Nabogenin was a mixture consisting mainly of Scilliglaucosidin.

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8. Mitteilung über die Glykoside vonBowiea vocubilis Harvey und 162. Mitteilung über Glykoside und Aglykone.

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7. Mitt.:A. Katz, Helv. chim. Acta38, 1565 (1955).

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161. Mitt.:H. Kündig-Hegedüs undO. Schindler, Helv. chim. Acta39, 904 (1956).     

A simple gas liquid chromatography procedure for determination of cannabinoidic acids inCannabis sativa L.

Résumé La chromatographie gazeuse des extraits de la marihuana donne la quantité complète de chaque composant cannabinoïque; tandis que la silylation des extraits précédant la chromatographie gazeuse, fournit des informations indépendentes sur les formes acides et non acides de chaque composant cannabinoïque.

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Department of Pharmacognosy, School of Pharmacy, University of Mississippi, research supported by National Institute of Mental Health, Contract No. HSM-42-70-109.     

Ultramikromethoden. Acetylierung von Alkoholen

Summary An acetylation procedure for nanogram amounts of alcohols is described.

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1. Mitteilung: Experientia27, 1376 (1971).     

Ultramikromethoden. Darstellung von Diazomethan; Methylierung von Fettsäuren mittlerer Kettenlänge

Summary A device for the small-scale generation of diazomethane is described, as well as the methylation by this reagent of nanogram amounts of the following fatty acids: butyric, caproic, caprylic, capric, lauric.

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3. Mitteilung:S. Huwyler, Experientia28, 1393 (1972).

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Herrn Prof. Dr.M. Viscontini danke ich für wertvolle Diskussionen und dem Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung für die finanzielle Unterstützung.     

The sugar component of aranciamycin:2-O-methyl-l-rhamnose

Zusammenfassung Der Zuckerbaustein des Antibiotikums Aranciamycin ist die2-O- Methyl-l-rhamnose.

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82nd communication of the series: Metabolic Products of Microorganisms. 81st comm. see: H.Diekmann, Arch. Mikrobiol., in press (1970).     

Robustaflavone—the first member of a new series of biflavones

Zusammenfassung Isolierung und Strukturaufklärung eines neuen Typs der Biflavone ausAgathis robusta.

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Acknowledgment: The author is thankful to Council of Scientific and Industrial Research (CSIR), New Delhi, India, for financial assistance.     

p-Xylylenedicyanide and related compounds,weakly cytotoxic nitriles

Zusammenfassung Extrakte vonV. opulus von schwacher Zelltoxizität enthaltenp-Xylylendinitril. Die Isomeren,m- undp-Cyanohydrozimtsäurenitrile, wurden synthetisiert und auf ihre zelltoxischen Eigenschaften hin untersucht:p-Xylylendinitril erweist sich als am stärksten wirksam.

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The reported work was supported in part by grants Nos. AM 07147, FR 00354, GM 12755 and GM 33888 from the United States Public Health Service, National Institutes of Health. We are grateful to the management and staff of the Isaac Bernheim Foundation for their helpful assistance with plants.

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Inquiries on mass spectra should be directed to F.W.M.; all other inquiries should be directed to C.H.J.     

Occurrence of new imidazolealkylamines (Spinaceamine and 6-Methylspinaceamine) in skin extracts ofLeptodactylus pentadactylus labyrinthicus

Riassunto Estratti di pelle diLeptodactylus pentadactylus labyrinthicus contengono elevati quantitativi di imidazolalchilamine, fra cui due derivati imidazo-c-piridinici finora ignoti in natura: la spinaceamina e la 6-metilspinaceamina.

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Supported by grants from the Consiglio Nazionale delle Ricerche, Roma, and the Rockefeller Foundation, New York.     

Antibodies against connective tissue in collagen diseases

Zusammenfassung In SerenFebris rheumatica-Kranker wurden Autoantikörper gegen isolierte Hyaluronsäure durch Kollodion-Agglutination gefunden.

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Statistical evaluation:V. Malý. Technical assistence:Alena Sovákova.     

Isocardenolides

Zusammenfassung Ein einfacher Weg zur Synthese eines von zwei möglichen isomeren Cardenoliden wurde entwickelt und die Reaktionsfolge an Hand der Überführung von Pregnenolon in Isocardenolide V gezeigt.

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Steroids and Related Natural Products XXI. For the previous contribution refer to:G. R. Pettit andP. Hofer, Helv. chim. Acta46, 2142 (1963).

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A preliminary account of this study was presented (December 1963) at the VI. Pan-American Congress of Pharmacy and Biochemistry, Mexico City (Mexico).

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This investigation was supported by PHS Research Grants CY-4074 (C3) to CA-04074-06 from the National Cancer Institute, Public Health Service.     

Changes of evoked potentials in lateral geniculate body and visual cortex during repetitive photic stimulation in the ‘Cerveau isolé’ cat

Riassunto La stimolazione fotica iterativa produce abitudine dei potenziali visivi nel gattocerveau isolé. La stimolazione olfattoria o l'attivazione elettrica della sostanza reticolare mesencefalica provocano risveglio elettroencefalografico e disabitudine.

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This research has been sponsored jointly by the Office of Scientific Research of the Air Research and Development Command, United States Air Force, through its European Office, under Contract No. AF 61(052)-107 and by the Rockefeller Foundation.

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Fellowship of the Italian Government. On leave from: Institut de Physiologie, Université de Louvain (Belgique).     

Komplex-Stabilität und tuberkulostatische Aktivität einiger 8-Oxychinolinderivate

Summary Based on polarographic viz. spectrophotometric determinations of the stabilities of several Cu⁺⁺- and Co⁺⁺⁺ hydroxyquinolin complexes it has been shown that a correlation exists between the quotient of complex-stabilitiesK _Co ⁺⁺⁺ /K _Cu ⁺⁺ and antitubercular activity (cf. table and graph). This supports the hypothesis that the 8-hydroxyquinolin derivatives and analogues act by competitive antagonism; the Cu⁺⁺-hydroxy-quinolates are able to replace Co in a prosthetic group of Mycobacterium-enzyme with Cu.

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Vorgetragen an der Organisch-Chemischen Konferenz des Vereines ungarischer Chemiker, 27. September 1953.

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III. Mitteilung: Acta chim. Hungarica (im Druck).     

Test-tube fertilization of ovules inMelandrium album mill. with pollen grains of several species of theCaryophyllaceae family

Zusammenfassung Samenanlagen vonMelandrium album wurden mit Pollenkörnern der folgenden Arten befruchtet:Melandrium album, M. rubrum, Silene schafta, S. tatarica, Dianthus carthusianorum. Es wird die weitere Entwicklung der Embryonen beschrieben.

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Dedicated to the memory of the late Professor P. Maheshwari who taught me and inspired me to undertake this work.     

Prolactin-sensitive neurons in the forebrain of some fishes

Zusammenfassung Intramuskuläre Injektionen von Schafprolaktin in immobilisierteLepomis gibosus undAstronotus ocellatus verändern die elektrische Aktivität von Vorderhirnneuronen; niedrige Dosen steigern, hohe hemmen sie.Tilapia leucosticta und Carassius auratus gibelio reagieren nur mit geringer kontinuierlicher Aktivierung.

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Acknowledgment: This work was supported by the Deutsche Forschungsgemeinschaft.     

Ultramikromethoden. Katalytische Hydrierung

Summary The catalytic hydrogenation of 1 ng of 1-hexadecene is described. The method is applicable to other 1-alkenes, and probably also to other kinds of unsaturated compounds, provided they fall into a definite range of volatility.

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4. Mitteilung: Experientia29, 735 (1973).

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Herrn Prof. Dr.M. Viscontini danke ich für wertvolle Diskussionen und dem Schweizerischen Nationalfonds zur Förderung der wissenschaftlichen Forschung für die finanzielle Unterstützung.     

Conformation and toxicity of amanitins

Zusammenfassung Die Cottoneffekte der Amanitine konnten dem Indolteil bzw. den Amidgruppen des Molekühls zugeordnet werden. Das untoxische Amanullin besitzt die gleiche Konformation wie die toxischen Peptide, das untoxische Aldoamanitin dagegen eine andere. Die absolute Konfiguration der Sulfoxidgruppe der Amatoxine ist identisch mit der des toxischen Phalloidinsulfoxids.

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Part 43 of the series: Components of the green deathcap toadstoolAmanita phalloides. Part 42:F. Fahrenholz, H. Faulstich andTh. Wieland, Liebigs Annln Chem.743, 83 (1971).

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Acknowledgment. The authors wish to express their gratitude toDr. A. Buku for preparation of methyl--aldoamanitin.     

Synchronization of mitosis inPhysarum polycephalum by coalescence of postmitotic and premitotic plasmodial fragments

Zusammenfassung Nach Fusion von promitotischen mit postmitotischen Fragmenten des SchleimpilzesPhysarum polycephalum (Zahlenverhältnis von postmitotischen zu promitotischen Kernen: 1/1) teilten sich die Kerne der so hergestellten Plasmodien synchron.

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Supported by AEC contract No. COO-1432-8.     

über Peptidsynthesen,XLVI. Synthese kininliefernder Kininogensequenzen

Summary H-Met-Lys-bradykinin-Ser-Val-Gln-OH and H-Met-Lys-bradykinin- Ser-Val-Gin-Val-OH, sequences of bovine serum kininogen have been synthetized by different approaches. The natural and synthetic peptides were tested for their kinin liberating potency.

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XLV. Mitt.: E.Klieger, Justus Liebigs Ann. Chem.,724, 204 (1969).