Weinberg's proof of the spin-statistics theorem

The aim of this paper is to offer a conceptual analysis of Weinberg's proof of the spin-statistics theorem by comparing it with Pauli's original proof and with the subsequent textbook tradition, which typically resorts to the dichotomy positive energy for half-integral spin particles/microcausality for integral-spin particles. In contrast to this tradition, Weinberg's proof does not directly invoke the positivity of the energy, but derives the theorem from the single relativistic requirement of microcausality. This seemingly innocuous difference marks an important change in the conceptual basis of quantum physics. Its historical, theoretical, and conceptual roots are here reconstructed. The link between Weinberg's proof and Pauli's original is highlighted: Weinberg's proof turns out to do justice to Pauli's anti-Dirac lines of thought. The work of Furry and Oppenheimer is also surveyed as a “third way” between the textbook tradition established by Pauli and Weinberg's approach.     

Plotinus’s conception of unity and multiplicity as the root to the medieval distinction between lux and lumen

Plotinus resolved the paradox of the immanent transcendence, characterizing the relation between the One and the universe, through his theory of the two energeiai. According to this doctrine, all existents have an internal activity and an external activity: the internal activity comprises the true essence and substance of each being; the external activity is emitted outwards as its image. The source of the emission is thus present in the lower layer of being by virtue of its manifold images. The prominence given to light in elucidating this solution led to a distinction between two types of lights: an original light, corresponding to the internal energeia of every existent, and a secondary light, which is the outflow and image of the first light, existing outside of the luminous body.This paper demonstrates the striking similarity between these two Plotinian lights and the concepts of lux and lumen developed by two thirteenth-century philosophers: Robert Grosseteste and Albertus Magnus. Moreover, the paper contends that the purpose of these two medieval concepts of light was identical to what Plotinus had in mind when he first made the distinction: to account for the relation between the one and the many.     

Hidden depths: Halley, hell and other people

During the long eighteenth century, boundaries between theology and natural philosophy, between imaginary and factual travel narratives, between fiction and social commentary, were far more fluid than they are today. To explore these relationships, this paper links Mary Shelley’s Frankenstein—a book often hailed as the first science fiction novel—to two earlier works which are now less well known: Edmond Halley’s article about terrestrial magnetism, in which he suggested that God had created inhabited illuminated cavities inside the earth; and a satirical fantasy voyage written by the Danish author Ludvig Holberg, but published anonymously as Niels Klim’s journey to the underground and immediately translated into many languages. Attention is focussed on how the ambiguous presentation of these and other texts blurs any straightforward classification of genres. The aim of examining these writers together is not to search for direct mappings from one project to another, but instead to introduce Holberg’s unfamiliar yet important book and also to cast new light on Frankenstein, one of England’s most famous works of literature.     

β-Lactam resistance in Staphylococcus aureus: the adaptive resistance of a plastic genome

Staphylococci have two mechanisms for resistance to β-lactam antibiotics. One is the production of β-lactamases, enzymes that hydrolytically destroy β-lactams. The other is the expression of penicillin-binding protein 2a (PBP 2a), which is not susceptible to inhibition by β-lactam antibiotics. Strains of S. aureus exhibiting either β-lactamase or PBP 2a-directed resistance (or both) have established a considerable ecological niche among human pathogens. The emergence and subsequent spread of bacterial strains designated as methicillin-resistant S. aureus (MRSA), from the 1960s to the present, has created clinical difficulties for nosocomial treatment on a global scale. The recent variants of MRSA that are resistant to glycopeptide antibiotics (such as vancomycin) have ushered in a new and disconcerting chapter in the evolution of this organism. Received 2 April 2005; received after revision 15 July 2005; accepted 25 July 2005     

Mechanisms, principles, and Lorentz's cautious realism

I show that Albert Einstein's distinction between principle and constructive theories was predated by Hendrik A. Lorentz's equivalent distinction between mechanism- and principle-theories. I further argue that Lorentz's views toward realism similarly prefigure what Arthur Fine identified as Einstein's “motivational realism.”     

The priority of internal symmetries in particle physics

In this paper, I try to decipher the role of internal symmetries in the ontological maze of particle physics. The relationship between internal symmetries and laws of nature is discussed within the framework of “Platonic realism.” The notion of physical “structure” is introduced as representing a deeper ontological layer behind the observable world. I argue that an internal symmetry is a structure encompassing laws of nature. The application of internal symmetry groups to particle physics came about in two revolutionary steps. The first was the introduction of the internal symmetries of hadrons in the early 1960s. These global and approximate symmetries served as means of bypassing the dynamics. I argue that the realist could interpret these symmetries as ontologically prior to the hadrons. The second step was the gauge revolution in the 1970s, where symmetries became local and exact and were integrated with the dynamics. I argue that the symmetries of the second generation are fundamental in the following two respects: (1) According to the so-called “gauge argument,” gauge symmetry dictates the existence of gauge bosons, which determine the nature of the forces. This view, which has been recently criticized by some philosophers, is widely accepted in particle physics at least as a heuristic principle. (2) In view of grand unified theories, the new symmetries can be interpreted as ontologically prior to baryon matter.     

Between autobiography and reality: Popper's inductive years

On the basis of his unpublished thesis ‘Gewohnheit und Gesetzerlebnis in der Erziehung’ (1926–7) a historical reconstruction is given of the genesis of Popper's ideas on induction and demarcation which differs radically from his own account in Unended quest. It is shown not only that he wholeheartedly endorses inductive epistemology and psychology but also that his ‘demarcation’ criterion is inductivistic. Moreover it is shown that his later demarcation thesis arises not from his worries about, on the one hand, Marxism and psychoanalysis and, on the other hand, Einstein's physics, but rather from his urgent preoccupation with providing pedagogy with a psychological foundation, which has its sources in Karl Bühler's cognitive psychology as well as, surprisingly, Adler's Characterology. Aside from Adler some lesser known psychologists, such as Karl Groos, will also be seen to have played a formative role on Popper's early thinking.     

Energy conservation and supertasks

The most recent results in the dynamics of infinite systems of particles have shown there is no necessary connection between the performance of a deterministic supertask and the non-conservation of energy. Much more difficult to prove is the non-existence of any necessary connection between the performance of an indeterministic supertask and the non-conservation of energy; however, this paper does just that. So the requirement that energy be conserved does not mean we can exclude as “non-physical” either of the two major types of supertask considered to date. The paper also proposes, in this context, a “hidden variables method” to prove general results of compatibility in dynamics.     

Mill and Lewis on laws,experimentation, and systematization

Mill appears to be committed to two incompatible accounts of laws. While he seems to defend a Humean account of laws similar to Ramsey’s and Lewis’s, he also appears to rely on modal notions to distinguish lawful relations from accidental regularities. This paper will show that Mill’s two accounts of laws are in fact equivalent. This equivalence results from a proper understanding of the necessity involved in laws and a proper understanding of systematization. This equivalence reveals the true source of the intimate connection between laws and systematization. Mill also provides an account of natural necessity that makes clear why experimentation is essential for gaining knowledge of laws. In contrast, Lewis’s account will be shown to have counterintuitive consequences regarding the relationship between laws and experimentation. Moreover, it will be shown that Mill’s views about inference result in a distinction between two modes of systematizing: subsumption and derivation. This distinction is overlooked in contemporary accounts of systematization, but Mill rightly notes that the metaphysical implications and epistemic role of these two modes are importantly different.     

The problem of time's arrow historico-critically reexamined

Responding to Hasok Chang's vision of the history and philosophy of science (HPS) as the continuation of science by other means, I illustrate the methods of HPS and their utility through a historico-critical examination of the problem of “time's arrow”, that is to say, the problem posed by the claim by Boltzmann and others that the temporal asymmetry of many physical processes and indeed the very possibility of identifying each of the two directions we distinguish in time must have a ground in the laws of nature. I claim that this problem has proved intractable chiefly because the standard mathematical representation of time employed in the formulation of the laws of nature “forgets” one of the connotations of the word ‘time’ as it is used in ordinary language and in experimental physics.     

Why the Afshar experiment does not refute complementarity

A modified version of Young's experiment by Shahriar Afshar demonstrates that, prior to what appears to be a “which-way” measurement, an interference pattern exists. Afshar has claimed that this result constitutes a violation of the Principle of Complementarity. This paper discusses the implications of this experiment and considers how Cramer's Transactional Interpretation easily accommodates the result. It is also shown that the Afshar experiment is analogous in key respects to a spin one-half particle prepared as “spin up along x”, subjected to a nondestructive confirmation of that preparation, and post-selected in a specific state of spin along z. The terminology “which-way” or “which-slit” is critiqued; it is argued that this usage by both Afshar and his critics is misleading and has contributed to confusion surrounding the interpretation of the experiment. Nevertheless, it is concluded that Bohr would have had no more problem accounting for the Afshar result than he would in accounting for the aforementioned pre- and post-selection spin experiment, in which the particle's preparation state is confirmed by a nondestructive measurement prior to post-selection. In addition, some new inferences about the interpretation of delayed choice experiments are drawn from the analysis.     

What leads from <Emphasis Type="Italic">dead-end?</Emphasis>

The 129 mouse strain develops congenital testicular germ cell tumors (TGCTs) at a low frequency. TGCTs in mice resemble the testicular tumors (teratomas) that occur in human infants. The genes that cause these tumors in 129 have not been identified. The defect at the Ter locus increases TGCT incidence such that 94% of 129-Ter/Ter males develop TGCTs. The primary effect of the Ter mutation is progressive loss of primordial germ cells (PGCs) during embryonic development. This results in sterility in adult Ter/Ter mice on all mouse strain backgrounds. However, on the 129 background, Ter causes tumor development in addition to sterility. Therefore, Ter acts as a modifier of 129-derived TGCT susceptibility genes. Ter was identified to be a mutation that inactivates the Dead-end1 (Dnd1) gene. In this perspective, I discuss the possible areas of future investigations to elucidate the mechanism of TGCT development due to Dnd1 inactivation. Received 29 September 2006; received after revision 29 January 2007; accepted 19 February 2007     

Biotransformation of a dietary sesterterpenoid in the Mediterranean nudibranchHypselodoris orsini

The metabolic relationship between the marine molluscHypselodoris orsini and the spongeCacospongia mollior has been reinvestigated. The predator-prey association has been confirmed even though the metabolic patterns of the two invertebrates are substantially different. Most probably the nudibranch converts the main sponge metabolite, the sesterterpenoid scalaradial (1), into a less oxygenated related metabolite, deoxoscalarin (4), followed by a second chemical transformation leading to a new sesterterpenoid, 6-keto-deoxoscalarin (5) which is selectively compartmentalized into some dorsal glands, mantle dermal formations (MDFs), strategically distributed near the gills. 6-keto-deoxoscalarin (5) has been characterized by 1D and 2D NMR methods. Finally, the unusual association of some Chromodorididae molluscs with sponges containing sesterterpenoids suggests a further analysis of their taxonomical collocation is required.     

William Whiston, Isaac Newton and the crisis of publicity

William Whiston was one of the first British converts to Newtonian physics and his 1696 New theory of the earth is the first full-length popularization of the natural philosophy of the Principia. Impressed with his young protégé, Newton paved the way for Whiston to succeed him as Lucasian Professor of Mathematics in 1702. Already a leading Newtonian natural philosopher, Whiston also came to espouse Newton’s heretical antitrinitarianism in the middle of the first decade of the eighteenth century. In all, Whiston enjoyed twenty years of contact with Newton dating from 1694. Although they shared so much ideologically, the two men fell out when Whiston began to proclaim openly the heresy that Newton strove to conceal from the prying eyes of the public. This paper provides a full account of this crisis of publicity by outlining Whiston’s efforts to make both Newton’s natural philosophy and heterodox theology public through popular texts, broadsheets and coffee house lectures. Whiston’s attempts to draw Newton out through published hints and innuendos, combined with his very public religious crusade, rendered the erstwhile disciple a dangerous liability to the great man and helps explain Newton’s eventual break with him, along with his refusal to support Whiston’s nomination to the Royal Society. This study not only traces Whiston’s successes in preaching the gospel of Newton’s physics and theology, but demonstrates the ways in which Whiston, who resolutely refused to accept Newton’s epistemic distinction between ‘open’ and ‘closed’ forms of knowledge, transformed Newton’s grand programme into a singularly exoteric system and drove it into the public sphere.     

Expression and immunolocalisation of odorant-binding and chemosensory proteins in locusts

We have identified, cloned and expressed a new chemosensory protein (CSP) in the desert locust Schistocerca gregaria belonging to a third sub-class of these polypeptides. Polyclonal antibodies stained a band of 14 kDa, as expected, in the extracts of antennae and palps of the adults, but not in the 4th and 5th instars. In the related species Locusta migratoria, instead, the same antibodies cross-reacted only with a band of apparent molecular mass of 35 kDa in the extract of 1st–5th instars, but not in the adults. The recombinant protein binds the fluorescent probe N-phenyl-1-naphthylamine, but none of the compounds so far reported as pheromones for S. gregaria. The expression of the odorant-binding protein (OBP) and of CSPs of sub-classes I and II was also monitored in antennae, tarsi, palpi, wings and other organs of solitary and gregarious locusts in their nymphal and adult stages. OBP was found to be antenna specific, where it is expressed at least from the 3rd instar in both solitary and gregarious locusts. CSPs, instead, appear to be more ubiquitous, with different expression patterns, according to the sub-class. Immunocytochemistry experiments revealed that OBP is present in the sensillum lymph of sensilla trichodea and basiconica, while CSP-I and CSP-III were found in the outer sensillum lymph of sensilla chaetica and in the sub-cuticular space between epidermis and cuticle of the antenna. Sensilla chaetica on other parts of the body showed the same expression of CSP-I as those on the antenna.Received 11 Janury 2005; received after revision 21 February 2005; accepted 18 March 2005X. Jin and A. Brandazza contributed equally to this work.     

Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significance

Molecular determinants of antimalarial drug resistance are useful and informative tools that complement phenotypic assays for drug resistance. They also guide the design of strategies to circumvent such resistance once it has reached levels of clinical significance. Established resistance to arylaminoalcohols such as mefloquine and lumefantrine in SE Asia is mediated primarily by gene amplification of the P. falciparum drug transporter, pfmdr1. Single nucleotide polymorphisms in pfmdr1, whether assessed in field isolates or transfection experiments, are associated with changes in IC₅₀ values (to arylaminoalcohols and chloroquine), but not of such magnitude as to influence clinical treatment outcomes. Recently described emerging in vitro resistance to artemisinins in certain areas correlates with mutations in the SERCA-like sequence PfATP6 and supports PfATP6 as a key target for artemisinins. Received 13 February 2006; revised after revision 7 March 2006; accepted 29 March 2006     

Phytotoxins as potential herbicides

Phytotoxins are produced in various culture media by many fungi that are pathogenic to weeds. These phytotoxins belong to a wide array of chemical substances including sesquiterpenoids, sesterterpenoids, diketopiperazines, peptides, spirocyclic lactams, isocoumarins, and polyketides. In most cases, the phytotoxin belongs to a family of related compounds produced by the fungus. These related compounds may or may not be phytotoxins. Phytotoxin production, in some cases, is optimized by the addition of a host extract to the culture medium. Biological activity is usually observed in a range of concentrations from 10^–3 to 10^–6 M. The concept of using these molecules, derivatives thereof, or related compounds as herbicides should be explored.     

Regular oscillations in suspensions of a putatively chaotic mutant ofDictyostelium discoideum

Summary We have tested the light-scattering properties of suspensions of theDictyostelium discoideum mutantHH201 derived from the mutantFr17. Previous studies indicated thatHH201 andFr17 possess highly irregular rhythmic properties which might represent aperiodic oscillations, i.e. chaos. We report that the former mutant can display regular oscillatory behavior. Possible explanations for this result are discussed, including that of a transition from chaotic to periodic behavior resulting from some parameter change or from strong intercellular coupling in cell suspensions.     

Rehabilitating theory: refusal of the ‘bottom-up’ construction of scientific phenomena

In this paper I inquire into Bogen and Woodward’s (1988) data/phenomena distinction, which in a similar way to Cartwright’s construal of the model of superconductivity (1995)—although in a different domain—argues for a ‘bottom-up’ construction of phenomena from data without the involvement of theory. I criticise Bogen and Woodward’s account by analysing their melting point of lead example in depth, which is usually cited in the literature to illustrate the data/phenomenon distinction. Yet, the main focus of this paper lies on Matthias Kaiser’s (1995) case study of the plate tectonic revolution, the most extensive case study that has been put forth to support the bottom-up construction of phenomena. On the basis of new historical evidence, which has been overlooked not only by Kaiser but also by the entire historical literature on the plate tectonic revolution, I demonstrate that phenomena are not constructed from the bottom-up but rather, admittedly counter-intuitively, from the top-down.     

Pectinoacetals A-C: novel sterol hemiacetals from the gorgonianCtenocella pectinata

Three polyhydroxylated sterol hemiacetals, pectinoacetals A-C (1–3) have been isolated as their acetyl derivatives (4–6) from the acetic anhydride treated organic extract of the Indo-Pacific gorgonianCtenocella pectinata. These natural products were found to undergo very rapid epimerization at the C-18 chiral center and thus exist only as an equilibrium mixture of two diastereomers. The structure assignments are based on spectral studies and chemical modifications of the natural products.