Absence of endotoxin-fever but not hyperthermia in Brattleboro rats

I.c.v. administration of bacterial endotoxin produced a fever in the Long-Evans rat but not in the Brattleboro rat. Similar administration of arachidonic acid, prostaglandin E2, prostacyclin, dibutyryl cAMP, norepinephrine, morphine and beta-endorphin caused hyperthermia in both Long-Evans and Brattleboro rats. Variable doses of exogenous arginine vasopressin (AVP) when centrally administered with endotoxin caused fever in the Brattleboro rat. It is suggested that AVP may play an important role in the production and release of endogenous pyrogen.     

Peculiar response of Brattleboro rats to selenite

Summary Brattleboro rats were given, on the 10th day of life, a single high dose of sodium selenite. 90% of Brattleboro heterozygotes responded to the treatment by the formation of cataract whereas homozygotes with diabetes insipidus exhibited no cataract.     

Lowering of liver acetaldehyde but not ethanol concentrations by pretreatment with taurine in ethanol-loaded rats

A rise in blood and liver acetaldehyde concentrations following ethanol loading (1.5 g/kg b.wt) was significantly reduced when rats were pretreated orally with taurine (0.5 g/kg), a potent in vitro activator of yeast aldehyde dehydrogenase. This taurine pretreatment produced a 4-fold increase in liver taurine content.     

Lowering of liver acetaldehyde but not ethanol concentrations by pretreatment with taurine in ehtanol-loaded rats

Summary A rise in blood and liver acetaldehyde concentrations following ethanol loading (1.5 g/kg b.wt) was significantly reduced when rats were pretreated orally with taurine (0.5 g/kg), a potent in vitro activator of yeast aldehyde dehydrogenase. This taurine pretreatment produced a 4-fold increase in liver taurine content.     

Absence of dehydroxylation of caffeic acid in germ-free rats

Zusammenfassung Nachweis, dass die Dehydroxylierung von Kaffeesäure zum-Hydroxy-phenyl-propionsäure durch intestinale Mikroorganismen erfolgt, wie FÜtterungsversuche mit normalen und keimfreien Ratten zeigten.     

The renal concentrating ability of newly born Brattleboro rats (hereditary diabetes insipidus).

In Brattleboro rats, there was no difference in urine osmolality between animals with and without diabetes insipidus after water deprivation up to age 14 days, and it appeared at age 18 days due to increase of osmolality in non-diabetic individuals.     

Absence of renin secretion in the portal venous system in rats

Zusammenfassung An 2–24h nephrektomierten männlichen und weiblichen Wistar-Ratten wurden Vergleichsbestimmungen der Renin-Aktivität im arteriellen und portalvenösen Plasma durchgeführt. Die Renin-Aktivität war in beiden Gefässystemen auf nicht messbare Werte abgefallen. Die infolge Blutentzug von 10–12 ml/kg erzielte hämorrhagische Hypotension führte im Zeitraum von 60–165 min nicht zu einem Renin-Aktivitätsanstieg. Die Versuchsresultate ergeben keine Bestätigung, dass Renin in der portalen Strombahn produziert oder freigesetzt wird.     

Antidiuretic effects of oxytocin in the Brattleboro rat

Summary The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1 g/h, 1.0 g/h, and 5 g/h of OT. OT infused at the rate of 5 g/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity.     

Renin in mouse but not in rat submandibular glands

Summary Renin was found in the submandibular glands of male Quackenbush mice in concentrations higher than has been reported for any tissue of any strain or species. However, no renin-like activity could be detected in glands from male and female Wistar rats using either pH 5.8 or 7.4 for assay and a radioimmunoassay specific for renin's reaction product, angiotensin I. Rabbit submandibular glands contained renin.We wish to express our sincere thanks to Dr E. Hackenthal for his suggestions. This study was supported by the National Heath and Medical Research Council of Australia.     

Renin in mouse but not in rat submandibular glands

Renin was found in the submandibular glands of male Quackenbush mice in concentrations higher than has been reported for any tissue of any strain or species. However, no renin-like activity could e detected in glands from male and female Wistar rats using either pH 5.8 or 7.4 for assay and a radioimmunoassay specific for renin's reaction product, angiotensin I. Rabbit submandibular glands contained renin.     

Antidiuretic effects of oxytocin in the Brattleboro rat

The antidiuretic activity of oxytocin (OT) was measured in Brattleboro rats with congenital diabetes insipidus. A dose dependent antidiuretic response was found in animals receiving chronic infusions of 0.1 micrograms/h, 1.0 micrograms/h, and 5 micrograms/h of OT. OT infused at the rate of 5 micrograms/h over a 7-day period completely reversed the symptoms of diabetes insipidus. The results support the concept that OT serves as a weak agonist of vasopressin at the level of the kidney and at pharmacological levels exhibits antidiuretic activity.     

Absence of tooth malformation in offspring of rats treated with a long-acting sulphonamide

Riassunto La 2-sulfanilamido, 3-metossi-pirazina, a differenza della 2-sulfanilamido, 4-6-dimetossi-pirimidina, non induce malformazioni dentarie nella prole, qualora venga somministrata al ratto durante la gestazione.