含硫双Schiff碱及其金属配合物的合成与生物活性研究

合成了茚三酮-1,3-双缩肼基二硫代甲酸苄酯(HL1),茚三酮-1,3-双缩氨基硫脲(HL2)2种含硫双Schiff碱及它们的铜、钴等金属配合物,通过元素分析、红外光谱、紫外-可见光谱、差热和摩尔电导的测试等对其进行了表征.并测试了双Schiff碱配体对大肠杆菌、枯草芽孢杆菌的抑菌活性.     

含硫席夫碱及其锰配合物的合成与生物活性

合成了2-乙酰基吡嗪单缩二氨基硫脲、2-乙酰基吡嗪缩二氨基硫脲缩5-氯水杨醛及其锰配合物,用IR、UV、元素分析等多种手段对它们进行了表征,并测试了它们对金黄色葡萄球菌、枯草芽孢杆菌、苏云金芽孢杆菌、大肠杆菌和铜绿假单孢菌的抑制情况．     

吡啶-3-甲醛双缩硫代对称二氨基脲席夫碱-邻菲咯啉配合物的合成及其生物活性研究

研究合成了Schiff碱吡啶-3-甲醛双缩硫代对称二氨基脲(HL)及其与Pb(NO3)2、Bi(NO3)的配合物,通过元素分析、红外光谱和紫外光谱对配体和配合物进行了表征,测试了配体和配合物的生物活性.     

双呋喃醛缩二氨基硫脲腙的分子结构测定

双呋喃醛缩二氨基硫脲腙的分子结构测定黄泰山，姚志扬（化学系）为进一步了解杂环羰基化合物和肼基的缩合反应，并系统比较这一类杂环单缩氨基硫脲腙和双缩二氨基硫脲腙的分子结构对生理药理的相关性，特别是它们的抗结核菌和化疗作用￣［１，２］，以前曾合成吡啶，呋喃...     

新型胆酸缩氨基硫脲衍生物的合成与抗菌活性研究

通过甾酮与取代氨基硫脲缩合,合成了一系列新型的胆酸缩氨基硫脲衍生物.其结构均经1H NMR,IR,ESI-MS及元素分析所证实.此外,所有目标化合物都进行了对金黄色葡萄球菌,枯草芽孢杆菌,绿脓杆菌,大肠杆菌的抗菌活性测试.化合物4b,4g和4h对绿脓杆菌和大肠杆菌都具有良好的抑制效果.     

某些氨基硫脲、缩氨基硫脲的抗细菌作用研究

本文报导了三种氨基硫脲、香草醛脲(4—苯基)氨基硫脲及后者的铜(Ⅱ)、锌(Ⅱ)、镍(Ⅱ)、镉(Ⅱ)配合物共八种化合物的体外抗细菌作用。所选菌种为三种常见细菌,它们分别是枯草芽孢杆菌、金黄色葡萄球菌及大肠杆菌,实验结果表明,香草醛缩(4—苯基)氨基硫脲在所试浓度范围内没有抗菌活性,部分配合物及氨基硫脲在较高浓度时呈现出一定的抗菌活性。     

两种新4,4'-联噻唑衍生物合成、表征及抗菌性研究

用自行制备的对氯苯甲酰氨基硫脲和邻氯苯甲酰氨基硫脲合成了两种4,4′-联噻唑衍生物:2,2′-二(对氯苯甲酰肼基)-4,4-联噻唑和2,2′-二(邻氯苯甲酰肼基)-4,4′-联噻唑,对化合物的结构经元素分析、红外光谱和核磁共振谱进行了表征,并对它们的抗菌活性进行了研究.     

异长叶烷基噻唑类化合物的合成及其生物活性

【目的】将噻唑环构建至异长叶烷酮分子中,得到具有新型生物活性化合物,拓展松节油的应用领域,提高松节油的利用价值。【方法】异长叶烷酮与氨基硫脲缩合,生成异长叶烷酮缩氨基硫脲; 异长叶烷酮缩氨基硫脲再与α-溴代苯乙酮衍生物发生环化反应,得到11种异长叶烷基噻唑类化合物2a—2k。采用FT-IR、¹H NMR、¹³C NMR、HPLC-MS等手段,对合成产物的结构进行了表征。采用最低抑制浓度(MIC)法和MTT法分别研究了异长叶烷基噻唑类化合物的抑菌活性和抗肿瘤活性。【结果】化合物4-(4-氯苯基)-2-(2-(1,1,5,5)-四甲基四氢-1H-2,4α-桥亚甲基萘-8(2H,5H,8αH)-亚基)肼基)噻唑(2b)和4-(2-萘基)-2-(2-(1,1,5,5)-四甲基四氢-1H-2,4α-桥亚甲基萘-8(2H,5H,8αH)-亚基)肼基)噻唑(2j)对枯草芽孢杆菌与荧光假单胞菌抑制效果较好,其最低抑制浓度(MIC)为7.5 μg/mL,化合物2b对真菌(白色念球菌与热带假丝酵母菌)的抑制效果优于其他化合物,其MIC值均为15.6 μg/mL; 异长叶烷酮缩氨基硫脲对人体肝癌细胞HepG2 的半抑制浓度(IC₅₀)为(34.5±0.8)μg/mL,表明其对HepG2具有较好的抗癌活性。【结论】异长叶烷酮缩氨基硫脲可作为潜在的抗肿瘤药物。     

不对称双缩二氨基硫脲席夫碱荧光探针的合成及其性能研究

利用噻唑-5-甲醛与单缩二氨基硫脲为原料,合成了一种新型不对称双席夫碱结构荧光探针N'-(4-氯亚苄基)-2-(噻唑-5-基亚甲基)肼基-1-硫代碳酰肼(L1),并对其结构进行了表征(NMR,IR,MS).在缓冲溶液(p H=7. 0)中,探针L1可以高选择性荧光识别Zn~(2+),检测限为5. 8×10~(-6)mol/L,p H适用范围为5~9.当Zn~(2+)与探针L1配位时,生成1:2型配合物(L-Zn2+),在365 nm紫外灯照射下,由无色变成亮绿色强荧光,具有潜在的应用价值.     

一种含硫Shiff碱及其金属螯合物研究

合成了一种茚三酮-1，3-双缩肼基二硫代甲酸苄酯配体(H2L)和它的钴、铜螯合物，并对合成的化合物进行了元素分析，UV，IR，1HNMR，MS和电导分析，初步推断出配体和螯合物(ML·xH2O，M=Co、Cu，x=1，2)的组成和结构．     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

An affordable accurate evaluation of the binding conformations predicted by molecular docking studies in bio-system

Franck-Condon factors bridge the gap between theoretical modeling and experimental observations for molecular electronic spectroscopy and electron transfer.Under the displaced harmonic oscillator approximation,multidimensional Franck-Condon factors are decomposed into a product of many one-dimensional(1D)Franck-Condon(FC)factors,and each 1D-FC factor is associated with one Huang-Rhys factor that determines the leading contribution of     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with     

Journal of Donghua University ( English Edition) Contents of Volume 31

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