Mastoparan induces hypothermia in mice

Summary The polypeptide mastoparan, isolated from the venom of the oriental Hornet,Vespa orientalis, induces hypothermia in white mice 15 minutes after its intraperitoneal injection. The hypothermic effect is induced by mastoparan obtained from different hornet and wasp venoms. The normal murine core temperature is lowered by mastoparan from 38°C to as faor as 33°C. This lowering lasts for one hour and is reversible.     

Chronopharmacology ofΔ 9-tetrahydrocannabinol hypothermia in mice

Résumé La température rectale de souris ayant subi une unique injection de ⁹THC (injection administrée soit le matin, soit l'après-midi, ou soit durant la nuit) a été mesurée 1, 2 et 4 h suivant cette injection. Chez les animaux, injectés l'après-midi, l'abaissement de température était maximal, mais il fut minimal chez les animaux injectés de nuit.     

Blockade of nicotinic receptors in brain with d-tubocurarine induces decreased metabolism,cutaneous vasodilation and hypothermia in rats

Summary Direct administration of d-tubocurarine into the lateral cerebral ventricle of conscious rats produced decreased metabolism, cutaneous vasodilatation and hypothermia at ambient temperatures of 8–22°C. Also, pretreatment with d-tubocurarine antagonized the arecoline-induced hypothermia.This work was supported by grants from the National Science Council of Republic of China and the Pjing-Ling Neurological Foundation (Veterans General Hospital, Taipei, Taiwan).     

Power frequency electric field induces biological changes in successive generations of mice

Summary Electromagnetic fields arising from the electrical power system are pervasively present in the environment. To help evaluate their public-health risk we raised 3 successive generations of mice in a low-strength, 60-Hz electric field. We found that the field caused an increased mortality in each generation, and, altered body weights in the 3rd generation.This work was supported by the National Institute of Environmental Health Sciences, Department of Health, Education and Welfare, the Environmental Protection Agency, and the Veterans Administration.     

Cholecystokinin-induced hypothermia in the rat

Summary Cholecystokinin-octapeptide (CCK-8) was shown to cause hypothermia after intracerebroventricular administration in the rat, and the hypothermic effect of CCK-8 was antagonized by simultaneous injection of TRH.     

Heparanase is preferentially expressed in human psoriatic lesions and induces development of psoriasiform skin inflammation in mice

Heparanase is the sole mammalian endoglycosidase that selectively degrades heparan sulfate, the key polysaccharide associated with the cell surface and extracellular matrix of a wide range of tissues. Extensively studied for its capacity to promote cancer progression, heparanase enzyme was recently implicated as an important determinant in several inflammatory disorders as well. Applying immunohistochemical staining, we detected preferential expression of heparanase by epidermal keratinocytes in human psoriatic lesions. To investigate the role of the enzyme in the pathogenesis of psoriasis, we utilized heparanase transgenic mice in a model of 12-O-tetradecanoyl phorbol 12-myristate 13-acetate-induced cutaneous inflammation. We report that over-expression of the enzyme promotes development of mouse skin lesions that strongly recapitulate the human disease in terms of histomorphological appearance and molecular/cellular characteristics. Importantly, heparanase of epidermal origin appears to facilitate abnormal activation of skin-infiltrating macrophages, thus generating psoriasis-like inflammation conditions, characterized by induction of STAT3, enhanced NF-κB signaling, elevated expression of TNF-α and increased vascularization. Taken together, our results reveal, for the first time, involvement of heparanase in the pathogenesis of psoriasis and highlight a role for the enzyme in facilitating abnormal interactions between immune and epithelial cell subsets of the affected skin. Heparanase inhibitors (currently under clinical testing in malignant diseases) could hence turn highly beneficial in psoriatic patients as well.     

Thyroid hormone synthesis during hypothermia in rats

Zusammenfassung Tiefe und oberflächliche Hypothermie an Ratten reduziert die Radiojodfixation der Schilddrüse. Markierte Jodtyrosine werden dedektiert, während Jodtyronine fehlen.     

Phenitrone and marihuana induced hypothermia

Résumé Le phénitrone, souvent considéré comme antagoniste spécifique de la marihuana, n'a non seulement pas empèché la baisse de température corporelle causé par la tétrahydrocannabinol (THC), mais potentialisé l'effet hypothermique de cette dernière. Il est possible que cette potentialisation est par suite du déplacement de la THC localisée dans les protéines plasmiques.     

The effect of hypothermia applied in the given stages of pregnancy on the number and form of vertebrae in the offspring of white mice

Zusammenfassung Trächtige Mäuseweibchen wurden in der Zeit zwischen dem 71/2. und 121/2. Tag der Gravidität im Hypothermieverfahren während eines Tages auf einer Körpertemperatur von 20°C oder 25°C gehalten. Insgesamt wurden 953 Tiere verwendet, von denen 114 insgesamt 533 Junge warfen. Von den letzteren zeigten 181 angeborene Missbildungen der Wirbelsäule, wie Reduktion der Wirbelzahl, Anomalien der Wirbelkörper und Wirbelbogen sowie Rippenanomalien.     

The antagonism of reserpine hypothermia by iproniazid

Zusammenfassung Durch Vorbehandlung mit Iproniazid wird die hypothermische Wirkung von Reserpin bei M?usen abgeschw?cht. Dieser Effekt geht mit der Monoaminoxydase-Hemmung parallel.      

The influence of hypothermia on arthus-phenomenon and leucotaxis

Zusammenfassung Es wurde an Kaninchen und Meerschweinchen festgestellt, daß Arthus-Phänomen und Leucotaxis durch Abkühlung verhindert werden können.     

Effects of acute hypothermia on the chick ERG

Zusammenfassung Mit der Abnahme der Körpertemperatur verminderte sich gleichzeitig die Amplitude derb- undc-Wellen des ERG. Zwei kleinere, von dena- undb-Wellen abgespaltene Komponenten wurden während der Abkühlung festgestellt, während nach Wiederherstellung der Hypothermie das ERG die normale Wellenform registrierte.

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The author is greatly indebted to Prof.I. Hanawa for his valuable advice and encouragement during this study. The author is also indebted to the Goto Hatchery Ind., Gifu City, for supplying the chicks.     

Relationship between hypothermia and some chlorpromazine induced metabolic changes in mouse brain

Zusammenfassung Es wird gezeigt, dass Chlorpromazin keine Veränderung der Konzentration von Aminosäuren erzeugt, wohl aber die Inkorporation des Isotopen¹⁴C-Glukose im säurelöslichen Anteil des Mäusegehirns temperaturabhängig vermehrt.

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Governors' Research Scholar, Guy's Hospital Medical School.