共查询到20条相似文献,搜索用时 15 毫秒
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Zusammenfassung Akuter Vitamin C-Mangel verursacht bei Meerschweinchen vorübergehenden Anstieg des Phospholipidspiegels im Blutserum, erhöhte Inkorporation des P32-Phosphates in die Leberphospholipide und eine markante Akkumulation von Leberphospholipiden. 相似文献
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J. van der Velden P. Borgdorff G. J. M. Stienen 《Cellular and molecular life sciences : CMLS》1999,55(5):788-798
To investigate whether during cardiac hypertrophy changes occur in contractile protein composition and in mechanical and
energetic properties of the myocardium, contractile protein composition, isometric force and adenosine triphosphate (ATP)
consumption were studied in control and hypertrophied guinea-pig hearts. Cardiac hypertrophy was induced by adding minoxidil
(120 or 200 mg/l) to the drinking water. Protein analysis was performed by one-dimensional gel electrophoresis. The myosin
heavy-chain (MHC) composition was determined in an enzyme-linked immunosorbent assay (ELISA). ATP consumption and force development
were simultaneously measured during isometric contraction in chemically skinned trabeculae. Histochemical analysis of cross-sectional
area of cardiomyocytes and interstitial space was performed on the left ventricular tissue of 200 mg/l minoxidil-treated and
control guinea pigs. Minoxidil treatment (120 and 200 mg/l) significantly increased left ventricular dry weight normalized
for body weight by 19 ± 4 and 24 ± 4%, respectively. No significant differences were found in the cellular cross-sectional
area, while interstitial space was slightly decreased in minoxidil-treated hearts. In left ventricular trabeculae of 200 mg/l
minoxidil-treated guinea pigs, ATPase activity was slightly less than in those of control guinea pigs, whereas force did not
differ significantly. Calcium sensitivity of force and ATPase activity were not affected by minoxidil treatment. Gel electrophoresis
revealed no difference in contractile protein composition, but a tendency towards a lower amount of α-MHC in the minoxidil-treated
hearts was found in ELISA.
Received 1 February 1999; accepted 15 March 1999 相似文献
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D. E. Cook J. D. Jackson M. R. Past C. M. Lang L. P. Bullock 《Cellular and molecular life sciences : CMLS》1984,40(8):840-841
Summary Both sexes of spontaneously diabetic guinea pigs exhibit hyperinsulinemia (>4-fold normal). This diabetic state is associated with the inhibition of hepatic drug metabolism in males but not females.Supported in part by NIH Grants AM 21282 from the NIAMDD and RR00469 from the DRR 相似文献
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P Federspil 《Experientia》1973,29(2):254-255
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Zusammenfassung Im Harn von weiblichen Meerschweinchen wurde im Gegensatz zu männlichen Tieren Epiandrosteron als Haupt-17-Ketosteroid nachgewiesen.Untersuchungen über die 17-Ketosteroidkonjugate im Harn von weiblichen Meerschweinchen ergaben, dass ein grosser Teil (30–40%) als freie Steroide nachweisbar ist. 40–50% liegen als Schwefelsäurekonjugate und 3–6% wahrscheinlich als Glucuronide vor. Bei den konjugierten 17-Ketosteroiden handelt es sich vornehmlich um 11-oxygenierte Steroide. 相似文献
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Contractile responses to acetylcholine were measured using isolated tracheae obtained from actively sensitized guinea pigs 0.5, 1, 5, 20, 24, 48 and 72 h after antigen challenge. Tracheal contractions to acetylcholine and to histamine were significantly increased 20 h but not 0.5, 1, 5, 24, 48 and 72 h after antigen challenge indicating bronchial hyperreactivity. When animals were pretreated with azelastine and then exposed to antigen challenge, concentration-response curve to acetylcholine did not differ from that obtained in control (non-challenged) tracheae. It is likely that azelastine is able to inhibit bronchial hyperresponsiveness to chemical mediators of bronchial asthma. 相似文献
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J L Parrot F Dray G Allouche M C Santais C Foussard F Dubois F Ruff 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1976,282(13):1289-1292
In guinea pigs actively sensitized with ovalbumin and shocked, we have measured blood histamine and histaminase, pulmonary content in cycli AMP and prostaglandins (PG) E1, E2 and F2alpha. In pulmonary efferent blood, both PGE and PGF are increased. In lung tissue, only PGF2alpha, which are bronchoconstructive mediators, are increased. Th increased level in PG seems to have two origins: first a specific increase, then an increased synthesis secondary to histamine release. 相似文献
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COMSA J 《Experientia》1956,12(7):272-273
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F R Heller 《Experientia》1984,40(12):1373-1375
In various organs of the guinea pig, the total cholesterol content of an organ was significantly correlated with the percentage of esterified cholesterol present in this organ. Cholesterol esterifying capacity was shown in most organs, with highest activities in the adrenals, the spleen and the liver. The significant correlation found between the cholesteryl ester content of an organ and its acyl cholesterol acyltransferase activity suggests a possible role of this enzyme in determining the level of the total and esterified cholesterol in a tissue. 相似文献
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F. R. Heller 《Cellular and molecular life sciences : CMLS》1984,40(12):1373-1375
Summary In various organs of the guinea pig, the total cholesterol content of an organ was significantly correlated with the percentage of esterified cholesterol present in this organ. Cholesterol esterifying capacity was shown in most organs, with highest activities in the adrenals, the spleen and the liver. The significant correlation found between the cholesteryl ester content of an organ and its acyl cholesterol acyltransferase activity suggests a possible role of this enzyme in determining the level of the total and esterified cholesterol in a tissue.This work was supported by a grant Crédit aux Chercheurs du Fonds National de la Recherche Scientifique of Belgium.Acknowledgments. I am indebted to Prof. C. Harvengt for his stimulating interest and helpful suggestions. I wish to thank Y. van Nieuwenhuyze and J. Costermans for their valuable laboratory assistance and Dr H. Baudon for pathological studies. 相似文献