Transport of a low molecular weight extracellular esterase into membrane vesicles of Candida lipolytica

The low mol. wt extracellular esterase of Candida lipolytica is actively transported into membrane vesicles. In the absence of metabolic energy, a proton gradient can drive the transport process. The transport system does not accumulate the enzyme at peak levels due to the presence of a leak pathway.     

Mutagenic effect of isopropyl methane sulphonate in mouse

Résumé Après avoir réalisé divers tests de toxicité, nous avons injecté des souris mâles par 15 méthane sulfonate d'isopropyl. Une dose de 100 mg/kg induit plus de 30% de mutations. Pour les stades méÏotiques, la proportion de déciduomes est plus faible et la proportion de morts avant implantation plus élevée que pour les stades post-méÏotiques. La période mutagène est suivie d'une période stérile (du 37me au 60me jour après injection) qui correspond probablement au traitement de stades spermatogoniaux.     

The effect of polysaccharide-protein complex isolated from Candida albicans on regional blood flow in rats.

After i.v. administration to rats of polysaccharide-protein complex, isolated from Candida albicans, a decrease of cardiac output was observed from 20 sec to 240 min postinjection, followed by a recovery at 360 min. Concomitantly the regional blood flow was maintained in heart and lungs, moderately decreased in intestine, liver and adrenals and markedly reduced in skin, muscle, spleen and kidney.     

Mutagenic effect of UV-light and X-rays onStreptomyces nigrifaciens and yield of the antifungal substance

Résumé Changement de capacité de production antibiotique chez mutants nouveaux deStreptomyces nigrifaciens.

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Thanks are due to PrincipalS. Sinha of Agra College, Agra, for providing all facilities and to C.S.I.R., New Delhi, for award of research followship to S.G.     

Effect of trypsin,S-adenosylmethionine and ethionine on L-serine sulfhydrase activity

Summary Trypsin causes an activation of serine sulfhydrase in the liver extracts from intact animals, but inhibits enzyme activity in the liver of ethionine treated rats. Trypsin also decreases an elevation of serine sulfhydrase activity caused by S-adenosylmethionine.This work was supported by the Serbian Medical Research Foundation.     

In vitro metabolism of ethionine, N-acetyl-ethionine and N-acetylmethionine by rat liver microsomes.

Rat liver microsomes deacetylated N-acetylethionine and N-acetyl-methionine to ethionine and methionine. The deacetylation of N-acetylmethionine was more rapid than the deacetylation of N-acetylethionine. Ethionine was slowly converted to ethionine sulfoxide by the microsomal preparations. N-Acetylethionine and N-acetylmethionine were not oxidized by the microsomes.     

Mutagenic action of ethylene halogenhydrins

Zusammenfassung Eine stark mutagene Wirkung wird durch äthylenchlorhydrin, äthylenbromhydrin und äthylenjodhydrin aufKlebsiella pneumoniae ausgeübt.     

Depression by ethionine of phosphorylating oxidation in hepatic mitochondria

Summary Induction of hepatic steatosis and suppression of hepatic ATP levels, protein synthesis and gluconeogenesis subsequent to administration of ethionine may be consequences of interference by this compound with mitochondrial phosphorylation of ADP. The mitochondrial dysfunction is not a direct action of ethionine on the organelle.     

Effects of ethionine and parafluorophenylalanine on the formation of peptidase A inPenicillium janthinelium

Résumé Ladl-éthionine et lap-fluorophénylalanine inhibent la formation de la peptidase A extracellulaire chez lePenicillium janthinellum sans affecter la synthèse de la protéine cellulaire.     

Depression by ethionine of phosphorylating oxidation in hepatic mitochondria

Induction of hepatic steatosis and suppression of hepatic ATP levels, protein synthesis and gluconeogenesis subsequent to administration of ethionine may be consequences of interference by this compound with mitochondrial phosphorylation of ADP. The mitochondrial dysfunction is not a direct action of ethionine on the organelle.