Enzymatic N-acetylation of tryptamine by brain homogenates of Locusta migratoria before and after intoxication by chlordimeform or lindane (author's transl)]

Brain homogenates of Locusta migratoria are found to possess enzyme capable of catalyzing the N-acetylation of tryptamine. A main product of the enzymatic reaction is isolated and identified as N-acetyltryptamine by chromatography analyse. Both insecticides, chlordimeform and lindane, inhibit enzyme activity. A direct correlation between the degree of intoxication and acetylation of tryptamine is described.     

Comparison of the morphogenic effects of JH-I and JH-III during the solitary phase of Locusta migratoria]

After injection of oiled solutions of JH-I metamorphosis was much more disturbed than following the same treatment with JH-III. The two hormones reduced in the same way the mortality which occurred after injection of pure peanut oil in the first hours of a larval stage. JH-1 and JH-III seemed to have the same effect on the two phases of Locusta.     

Monoamine oxidase activity of the hypothalamus and pituitary: alterations after pinealectomy, changes in photoperiod, or additions of melatonin in vitro.

Rat pituitary MAO activity was reduced by constant darkness and by additions of melatonin in vitro and was increased by constant light and by pinealectomy. Hypothalamic MAO activity followed the same pattern but was less dramatically affected. The data suggest that MAO may be a target enzyme for melatonin.     

Monoamine oxidase activity in single nerve cell bodies from substantia nigra of rat and man

Summary In single nerve cell bodies isolated from the substantia nigra of man and rat the active forms of MAO A and MAO B were found by the use of the microdiver technique and specific inhibitors.     

Monoamine oxidase inhibitors antagonize the acceleration of brain dopamine synthesis induced by neuroleptic drugs in vivo: Implications for the treatment of tardive dyskinesia

Zusammenfassung Pargylin und Pheniprazin vermindern stark die Dopa-Anreicherung (erhöhte Dopamin-Synthesegeschwindigkeit) im corpus striatum der Ratte nach Trifluoperazin und Tetrabenazin. Dopamin-spezifische MAO-Hemmer könnten deshalb therapeutischen Wert haben in der Kontrolle von tardiver Dyskinesia, die möglicherweise durch erhöhte Bildung und Umsatz von Dopamin unter dem Einfluss von anti-psychotischen Drogen hervorgerufen wird.     

Monoamine oxidase activity in single nerve cell bodies from substantia nigra of rat and man

In single nerve cell bodies isolated from the substantia nigra of man and rat the active forms of MAO A and MAO B were found by the use of the microdiver technique and specific inhibitors.     

Synaptic vesicle depletion and glutamate uptake in a nerve-muscle preparation of the locust,Locusta migratoria L

Summary Excitatory terminals, depleted of their synaptic vesicles by stimulation at high frequency, were incubated in the radiolabelled putative neurotransmitter, L-glutamate. Quantitative electron microscope autoradiography revealed that the axoplasm of these recovering terminals had accumulated the³H L-glutamate.Acknowledgment. The authors wish to thank Dr N. M. Blackett for running the computer analyses of the autoradiographical results. R. P. Botham gratefully acknowledges the SRC for financial assistance.     

Monoamine oxidase- and catechol-O-methyltransferase activity in umbilical vessels of the human fetus

Zusammenfassung Die MAO-Aktivitäten menschlicher Feten verhielten sich in folgender, abnehmender Reihe: Ductus venosus, Vena umbilicalis=Leber, Arteria umbilicalis=Nabelstrang. Die COMT-Aktivität hingegen erwies sich in allen untersuchten Gefässen als unbedeutend und war nur im Lebergewebe auffallend hoch.

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This study was supported by part by a grant of the Medical Faculty, University of Lund, the Magnus Bergwall's Foundation and Expressen's Prenatal Foundation.     

Absence of phosphogluconate pathway activity in normal and in ethanol-intoxicated slices from rat brain

Résumé L'auteur a repris la question de l'existence d'une voie oxydative fonctionnelle directe pour la glucose dans le cerveau adulte et constaté qu'elle ne peut être décelée ni dans des conditions normales ni lors d'une intoxication du sujet par l'étanol.     

Synthesis of juvenile hormones in vitro by the corpora allata of 5th stage larva of Locusta migratoria migratorioides (R and F) (Insecta, Orthopteroida)]

Corpora allata of Locusta migratoria 5th stage larvae synthesize J.H.1, J.H.2 and J.H.3 in vitro. The C.A. of insects of different ages exbit different rates of J.H. synthesis. J.H.1 and J.H.2 synthesis is less than 1 ng/48 h/gland. During the same time the J.H.3 production may be as much as 25.6 ng/gland. J.H. synthetic activity is the same between right and left C.A. The release of J.H. from the C.A. occurs immediately following synthesis. These results are compared with in vivo haemolymphatic J.H. levels.     

Ultrastructure of gonadotropic cells of the normal eel and after estradiol injection]

Male and female silver eels, in fresh water or sea water, have few gonadotrophs (GTH) poorly differentiated. An oestradiol (E2) treatment induces their development: a well developed Golgi area, abundant secretory granules (200-500 nm), dilated cisterna and large globules 1.2-2.2 micron) are observed. A positive feedback may control gonadotropin synthesis in immature eels. No macroscopic effect is discernible on the gonad.