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Repair of the choroidal vasculature following laser photocoagulation in the rat was examined with vascular casts and correlated with observations on thin-sections. The regenerative process began at the periphery of the damaged area, starting from the surviving choriocapillaris and venules, and proceeding towards the center by means of recanalization of damaged vessels and growth of new ones. In small healed lesions the capillary bed was re-formed. It resembled the adjacent undamaged choriocapillaris morphologically but appeared to be less dense than the intact choriocapillaris when examined by scanning microscopy. In large lesions the capillary bed was re-formed at the periphery but not at the center. Also present at the edges of the large lesions were groups of new vessels which, when observed by scanning microscopy, appeared to extend in two directions; towards the subretinal space and towards the choroidal network. Another aspect of the repair process was the simultaneous occurrence of new vessel growth and capillary regression, which was observed both at the level of the choriocapillaris and at the foci of new vessels. 相似文献
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M. Lazzari V. Franceschini G. Minelli F. Ciani 《Cellular and molecular life sciences : CMLS》1993,49(4):277-281
The corrosion cast technique provided for the first time an excellent three-dimensional visualization of the vascular pattern of the choroid and iris in the newt eye. The results show the presence of a single arterial afference to the choroidal and iris capillaries: the ophthalmic artery is the origin fo both ciliary arteries and the long posterior ciliary artery. Slightly behind the equatorial circumference of the eyeball the venous drainage consists of a single vessel on the dorsal side and two distinct vessels on the ventral one. It receives blood from both iris and choroid. The surface of the plastic endocasts shows some details of fine luminal structures of the endothelial cells. Shallow depressions may be regarded as imprints of endothelial cell nuclei, and they are distinctly different for arteries and capillaries. The angioarchitecture of the newt eye differs from that of brain in that hairpin-shaped capillary loops are not observed at all. 相似文献
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M. Murakami T. Nishida S. Iwanaga M. Shiromoto 《Cellular and molecular life sciences : CMLS》1984,40(9):958-960
Summary Scanning and transmission electron microscopic observations have been made in the terminal region of the vas deferens of the cat, with emphasis on the occurrence of spermiophagy. The present study has revealed that epithelial cells as well as luminal macrophages are extensively and actively involved in phagocytosis of spermatozoa. The mechanism of the spermiophagy is discussed, in relation to a possible role of the epithelial cells, as one function of the vas deferens. 相似文献
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Biomedicine and diseases: the Klippel-Trenaunay syndrome, vascular anomalies and vascular morphogenesis 总被引:2,自引:0,他引:2
Vascular morphogenesis is a vital process for embryonic development, normal physiologic conditions (e.g. wound healing) and pathological processes (e.g. atherosclerosis, cancer). Genetic studies of vascular anomalies have led to identification of critical genes involved in vascular morphogenesis. A susceptibility gene, VG5Q (formally named AGGF1), was cloned for Klippel-Trenaunay syndrome (KTS). AGGF1 encodes a potent angiogenic factor, and KTS-associated mutations enhance angiogenic activity of AGGF1, defining ‘increased angiogenesis’ as one molecular mechanism for the pathogenesis of KTS. Similar studies have identified other genes involved in vascular anomalies as important genes for vascular morphogenesis, including TIE2, VEGFR-3, RASA1, KRIT1, MGC4607, PDCD10, glomulin, FOXC2, NEMO, SOX18, ENG, ACVRLK1, MADH4, NDP, TIMP3, Notch3, COL3A1 and PTEN. Future studies of vascular anomaly genes will provide insights into the molecular mechanisms for vascular morphogenesis, and may lead to the development of therapeutic strategies for treating these and other angiogenesis-related diseases, including coronary artery disease and cancer.Received 24 November 2004; received after revision 21 January 2005; accepted 2 March 2005 相似文献