Indonesian Throughflow in an eddy-permitting oceanic GCM

An eddy-permitting quasi-global oceanic GCM was driven by wind stresses from reanalysis data for the period of 1958-2001 to get the time series of the upper circulation in the Indonesian Sea. The model represents a reasonable pathway of Indonesian Throughflow (ITF) with Makassar Strait making the major passage transfer the North Pacific water southward. The simulated annual mean ITF transport is 14.5 Sv, with 13.2 Sv in the upper 700 m. Annual cycle is the dominant signal for the seasonal climatology of the upper layer transport. Both the annual mean and seasonal cycle agree well with the observation. The overall correlation between the interannual anomaly of the ITF transport and Nino 3.4 index reaches -0.65 in the simulation,which indicates that ENSO-related interannual variability in the Pacific is dominant in controlling the ITF transport. The relationship between the interannual anomalies of ITF and sea surface temperature in the Pacific, the Indian Ocean is not fixed in the simulation. In 1994, for instance, the intensive Indian Ocean sea surface temperature anomaly plays a dominant role in the formation of an impressive large transport of ITF.     

Indonesian Throughflow in an eddy-resolving ocean model

The performance of the eddy-resolving LICOM2.0 in simulating the Indonesian Throughflow has been evaluated against the INSTANT data in the present study. The mean vertical structures of the along strait velocities are simulated well in LICOM2.0, but the large velocities at the bottom of the Lifamatola Passage and the Timor Passage cannot be reproduced by LICOM2.0. The causes are considered to be both the errors in the topography and the tidal mixing at the bottom. Despite several biases in the mean velocities, the mean inflow and outflow volume transports in LICOM2.0 are almost identical to the INSTANT data. Com- pared with the lower resolution LICOM, the most significant improvement is the better simulation of the partitions of the inflow and outflow transports in individual straits. The outflow for low-resolution LICOM is mainly through the Ombai and Lombok Strait, whereas that for LICOM2.0 is mainly through the Timor Passage. The variability of the vertical structure of velocities and the volume transport are also investigated, LICOM2.0 overestimates the magnitude of the upper-layer currents and the amplitude of the variation. We also found that the largest correlation coefficient occurs in the shallowest strait, the Lombok, whereas the lowest occurs in the Timor Passage, especially in the upper layer. The latter may be caused by the unrealistic transport through the Torres Strait in LICOM2.0.     

A haemoglobin switching activity modulates hereditary persistence of fetal haemoglobin

During human development there is a switch from fetal to adult haemoglobin formation, reflecting the differential expression of fetal (G gamma and A gamma) and adult (beta and delta) globin genes. Mutations that inhibit this switch produce variants of the syndrome of hereditary persistence of fetal haemoglobin (HPFH). Adult heterozygotes for these mutants produce 15-30% fetal haemoglobin (HbF) in their red cells. The general assumption is that the mutations result in a permanent switching on of gamma-globin genes. Here, however, we show that fetal globin expression can be turned off in cultures of HPFH cells by an uncharacterized factor in fetal sheep serum. This is the first demonstration that mutations affecting the developmental expression of globin genes can be modulated by exogenous factors. The findings raise the possibility that the phenotype of HPFH is not simply the direct result of mutations in or around globin genes but the consequence of the mutations on the interaction of globin genes with trans-acting regulatory factors.     

印尼中立主义外交初探

中立主义是冷战期间印尼外交政策的基本指导思想。印尼中立外交的特点是长期中立,国内政治体制的变动并没有动摇其中立主义的外交基石。中立主义外交既是印尼自身的地缘位置和政治文化影响的结果,又与印尼的国内政治需求存在着密切的联系。     

印尼中立主义外交初探

中立主义是冷战期间印尼外交政策的基本指导思想。印尼中立外交的特点是长期中立，国内政治体制的变动并没有动摇其中立主义的外交基石。中立主义外交既是印尼自身的地缘位置和政治文化影响的结果，又与印尼的国内政治需求存在着密切的联系。