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1.
P. Fonlupt M. Roche L. Cronenberger H. Pacheco 《Cellular and molecular life sciences : CMLS》1979,35(8):1089-1090
Summary S-Adenosylhomocysteine (10–7–10–5 M) activated norepinephrine (NE) and serotonin (5HT) in vitro uptake in synaptosomal preparations from rat brain, but did not affect dopamine (DA) uptake. When administered to rats (7 mg/kg i.p.), it had the same effect on in vitro NE and 5HT uptake. It did not affect NE and 5HT release.Work achieved within the frame of the research contract institut Mérieux., Institut National des Sciences Appliquées. 相似文献
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Subcellular fraction, enriched with synaptosomes, obtained from rat brain has been found contaminated by lysosomes, as evidenced by the high content of acid phosphatase, their biochemical marker. 相似文献
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P Fonlupt J Barailler M Roche L Cronenberger H Pacheco 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1979,288(2):283-286
S-adenosylmethionine (0,1 mg/kg/ip) decreases in vivo, norepinephrine (NE) synthesis and does not affect 5-hydroxytryptamine (5 HT) synthesis in the Rat brain. S-adenosylhomocysteine (7 mg/kg/ip) increases NE synthesis and decreases 5 HT synthesis. Neither nucleoside affects dopamine synthesis. 相似文献
4.
G Fillion J C Rousselle M Goiny P Pradelles F Dray J Jacob 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1977,285(3):265-268
A serotonine-sensitive adenylate cyclase system has been observed in horse brain membrane preparations. In crude mitochondrial fraction two types of activation sites were characterized, the Ka being = 2 nM and 1 micrometer. In purified synaptosomal membranes, a single adenylate cyclase activation was observed corresponding to the highest apparent affinity (KD = 2nM). This activation site might be related to the high affinity binding site (KD = 2NM) were previously described in the same membrane preparations. 相似文献
5.
Résumé Les effets de la lidoflazine ont été étudiés sur les bandelettes aortiques isolées du lapin et les bandelettes gastriques isolées du rat. La lidoflazine antagonise significativement la sérotonine sur ces 2 préparations sans altérer leurs réponses à l'angiotensine et à la noradrénaline. 相似文献
6.
A. Velasco-Martin P. Lorenzo-Fernandez P. D. Garcia de Jalon 《Cellular and molecular life sciences : CMLS》1973,29(9):1100-1101
Resumen El Sulpiride in vitro a la concentración de 1×10–2
M disminuye el consumo de Oxígeno en cortes de cerebro de rata. El exceso de potasio o ausencia de calcio en el medio de incubación, no modifican este efecto. En homogeneizado de cerebro total, unicamente a la concentración de 1×10–2
M deprime el consumo de oxígeno. A las concentraciones 1×10–3 y 1×10–4
M no modifica el consumo de oxígeno en cortes ni homogeneizados de cerebro. 相似文献
7.
Possible circadian and seasonal rhythmicity in an in vitro model: monoamine uptake in rat brain slices 总被引:2,自引:0,他引:2
A Wirz-Justice 《Experientia》1974,30(11):1240-1241
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Zusammenfassung 5-OH-Dopa und 5-OH-Dopamin senken in vivo den Serotoningehalt und vermindern in vitro dosisabhängig die Aufnahme von3H-Serotonin im Striatum von Ratten. Es kann daher angenommen werden, dass 5-OH-Dopamin in vivo überwiegend eine Verdrängung von Serotonin aus den serotoninergen Speichern verursacht, während in vitro zusätzlich eine Verdrängung von unspezifisch in katecholaminerge Speicher aufgenommenem Serotonin auftreten kann. 相似文献
10.
A. Velasco Martín J. M. Arévalo Alonso M. de Armijo Valenzuela 《Cellular and molecular life sciences : CMLS》1972,28(8):934-934
Resumen La mecloqualona inhibe in vitro, la respiración de cortes y homogenizados de cerebro, incrementando el consumo de glucosa; este último efecto no se produce cuando al medio de incubación se añaden 100 mM de potasio. 相似文献
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A. Velasco Martín J. M. Arévalo Alonso J. Castaneda Casado 《Cellular and molecular life sciences : CMLS》1972,28(9):1070-1071
Resumen El clorhidrato de Ketamina (1×10–3
M y 1×10–4
M) incrementa el consumo de oxigeno de cortes de cerebro de rata incubados en Krebs-Ringer fosfato conteniendo 5 mM ó 100 mM de potasio. La droga no modifica el consumo de oxigeno de homogeneizado de cerebro total. 相似文献
13.
Zusammenfassung Nachweis, dass Carbaryl die Konzentration von Serotonin und 5-Hydroxyindolessigsäure im Rattenhirn steigert. Der Zusammenhang mit einem Stress wird als möglich angenommen. 相似文献
14.
A Ramirez H Vial J Barailler H Pacheco 《Comptes rendus des séances de l'Académie des sciences. Série D, Sciences naturelles》1978,187(1):53-56
These drugs, except centrophenoxine, inhibit in vitro in a competitive manner, norepinephrin uptake in Rat hypothalamus and cortex, and dopamine uptake in corpus striatum and cortex, at higher concentrations than d.l. amphetamine; this alone inhibits serotonin uptake in hypothalamus. 相似文献
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Physostigmine in a dose of 0.1 mg/kg i.v. expressly stimulated the oxygen uptake in the rat cerebral cortex. This effect was blocked by propranolol and seems be mediated by catecholamines. Since atropine also antagonized the stimulant effect of physostigmine, it appears that the action of physostigmine is primarily cholinergic and that the adrenergic effect is a secondary phenomenon. The higher dose of physostigmine (0.4 mg/kg i.v.) caused a depression of rat brain oxygen uptake. 相似文献
17.
A. Klara Pfeifer E. Sz. Vizi Eva Satory Eva Galambos 《Cellular and molecular life sciences : CMLS》1963,19(9):482-483
Zusammenfassung Sieben Tage nach Adrenalektomie ist der 5-HT-Gehalt des Rattengehirns vermindert, während der NA-Gehalt unverändert bleibt. Chronische Hydrocortisonbehandlung restituiert, DOCA-Behandlung bleibt wirkungslos. Nach 5-HTP-Behandlung steigt der 5-HT-Gehalt auch im Gehirn der adrenalektomierten Tiere. 相似文献
18.
Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10(-4) M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.) inhibits only the in vitro uptake of DA but enhances the uptake of precursors. 相似文献
19.
Intracerebroventricular (i.c.v.) administration of des-Tyr1-gamma-endorphin (0.1 and 1.0 microgram) caused a decrease of the serotonin (5-HT) concentration of the hippocampus. The concentration of 5-HIAA and the pargyline-induced alterations in 5-HT and 5-HIAA were not affected. No effects were noticed in other brain regions. 相似文献
20.
Summary The present paper reports the first evidence that homocarnosine-carnosine synthetase from rat brain requires free sulfhydryl groups for activity. The activity of the synthetase can be stabilized by dithioerythritol and inhibited strongly by Cu2+, Cd2+, Hg2+, Zn2+, and to a lesser extent by Ca2+, Ni2+, Li, chlorpromazine, -methyl DOPA and norepinephrine at the concentrations tested.Acknowledgment. This work was supported by United States Public Health Service Grant No. NS-06137. 相似文献