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1.
Summary In perfused livers of 24 hour-fasted rats, PGE1 (prostaglandin E1) infused continuously into the perfusate, was found to cause a 45% increase in the incorporation of 1-14C acetate into liver fatty acids. PGE1 was found to have no effect, however, on the activity of the key lipogenic enzymes. 相似文献
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In perfused livers of 24 hour-fasted rats, PGE1 (prostaglandin E1) infused continuously into the perfusate, was found to cause a 45% increase in the incorporation of 1-14C acetate into liver fatty acids. PGE1 was found to have no effect, however, on the activity of the key lipogenic enzymes. 相似文献
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Résumé Les microsomes isolés du foic continuent à relâcher le prothrombin pendant l'incubation de façon désavantageuse pour la synthèse totale des protéines. L'accumulation est plus rapide quand les rats, soumis à un jeûne bref, étaient nourris de glucose avant le sacrifice. 相似文献
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W. H. Rotsztejn S. V. Drouva J. Epelbaum C. Kordon 《Cellular and molecular life sciences : CMLS》1982,38(8):974-975
Summary Somatostatin, in concentrations ranging from 10–10 M to 10–7 M, induces a dose-dependent inhibition of LHRH release from mediobasal hypothalamic slices incubated in vitro. In contrast, VIP, secretin, glucagon, substance P, neurotensin and arginine-vasotocin do not affect spontaneous release of LHRH. 相似文献
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T. N. Calvey 《Cellular and molecular life sciences : CMLS》1971,27(5):543-543
Zusammenfassung Die intrazellulären pH-Werte von Rattenleber wurden mit Hilfe der DMO-Verteilungsmethode untersucht. Der intrazelluläre pH-Mittelwert der Leberzellen betrug 7,17±0,09; die intra-extrazelluläre pH-Differenz war 0,23. 相似文献
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K. Mashita K. Tajima S. Kawamura S. Tarui 《Cellular and molecular life sciences : CMLS》1984,40(12):1429-1431
Summary Using indomethacin (Ind), a prostaglandin, synthesis inhibitor, in vivo experiments in rats and in vitro experiments with perifusion systems of rat thyroids and pituitaries were conducted. After 35 days of intragastric infusion of Ind, serum TSH levels were markedly increased, the thyroid was swollen and, as a consequence, T3 and T4 levels were normal. The T3 release from perifused rat thyroids under continuous stimulation with 10 mU/ml TSH was inhibited significantly (p<0.01) by 1.0×10–6 M Ind. On the other hand, the TSH release from perifused rat pituitaries under TRH stimulation was enhanced conspicuously by Ind. It was concluded that Ind decelerated thyroid hormone release from the thyroid and accelerated TSH release from the pituitary in perifusion systems. 相似文献
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Using indomethacin (Ind), a prostaglandin synthesis inhibitor, in vivo experiments in rats and in vitro experiments with perifusion systems of rat thyroids and pituitaries were conducted. After 35 days of intragastric infusion of Ind, serum TSH levels were markedly increased, the thyroid was swollen and, as a consequence, T3 and T4 levels were normal. The T3 release from perifused rat thyroids under continuous stimulation with 10 mU/ml TSH was inhibited significantly (p less than 0.01) by 1.0 X 10(-6) M Ind. On the other hand, the TSH release from perifused rat pituitaries under TRH stimulation was enhanced conspicuously by Ind. It was concluded that Ind decelerated thyroid hormone release from the thyroid and accelerated TSH release from the pituitary in perifusion systems. 相似文献
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T. Quesada L. Garcia-Torres F. Alba C. Garcia del Rio 《Cellular and molecular life sciences : CMLS》1979,35(9):1205-1205
Summary In the isolated and perfused kidney of the rat, the stimulant effect of dopamine on renin release is blocked by propanolol and not by haloperidol. This suggests that the release of renin induced by dopamine is due to the activation of \-receptors. 相似文献
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E. Fugassa G. Gallo A. Voci R. Accomando 《Cellular and molecular life sciences : CMLS》1982,38(1):81-82
Summary The routine procedure for the isolation of rat liver induces a significant fall in RNA polymerase I and II activities which are rapidly restored to the control levels during perfusion. 相似文献
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R. P. Rubin S. D. Jaanus E. Miele 《Cellular and molecular life sciences : CMLS》1969,25(12):1327-1328
Zusammenfassung Es wird gezeigt, dass die Freisetzung von ACTH in der durchströmten Katzennebenniere nur bei Anwesenheit von Kalzium erfolgt. Strontium, nicht aber Magnesium kann Kalzium freisetzen, während Magnesium (15 mM die Freisetzung von ACTH in Gegenwart von Kalzium hemmt. Ein Vergleich zwischen Brenzkatechinamin und Kortikosteronfreisetzung wird diskutiert. 相似文献
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H. Lee S. -P. Noel E. A. Hosein David Rubinstein 《Cellular and molecular life sciences : CMLS》1982,38(8):914-915
Summary Chronic alcohol feeding of a low fat diet for 5 weeks led to a slightly raised though statistically non-significant high density liproprotein cholesterol/apoB containing lipoprotein cholesterol ratio in both the fasting rat serum as well as the secretory products of the isolated perfused liver.Acknowledgments. Human RBC was kindly supplied by the Canadian Red Cross. This work was supported by MRC, DISCUS and the Department of National Health and Welfare, Canada. H. L. is the holder of an MRC studentship. 相似文献
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M. Del Tacca C. Blandizzi M. C. Bernardini F. Martelli A. Della Longa 《Cellular and molecular life sciences : CMLS》1989,45(8):734-736
Summary In order to investigate the role of peripheral GABA-B receptors, the effects of the putative GABA-B agonist baclofen on immunoreactive gastrin release from an isolated vascularly perfused rat stomach preparation were examined. The vascular infusion of baclofen at graded concentrations induced a dose-dependent increase in gastrin release; this was unaffected by the GABA-B antagonist delta-aminovaleric acid, but was fully prevented by the selective GABA-A antagonist bicuculline as well as by atropine or tetrodotoxin. These results suggest that the stimulant effects of baclofen are mediated by nervous cholinergic structures, associated with GABA-A receptors, and indicate that this GABA-B agonist must be regarded as a partial agonist of peripheral GABA-A receptors. 相似文献
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In order to investigate the role of peripheral GABA-B receptors, the effects of the putative GABA-B agonist baclofen on immunoreactive gastrin release from an isolated vascularly perfused rat stomach preparation were examined. The vascular infusion of baclofen at graded concentrations induced a dose-dependent increase in gastrin release; this was unaffected by the GABA-B antagonist delta-aminovaleric acid, but was fully prevented by the selective GABA-A antagonist bicuculline as well as by atropine or tetrodotoxin. These results suggest that the stimulant effects of baclofen are mediated by nervous cholinergic structures associated with GABA-A receptors, and indicate that this GABA-B agonist must be regarded as a partial agonist of peripheral GABA-A receptors. 相似文献
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J. A. Palma 《Cellular and molecular life sciences : CMLS》1976,32(11):1481-1482
Thyroid Stimulating Hormone (TSH) increased the levels of plasma fibrinogen in the presence or absence of the thyroid gland. This finding suggests that this hormone produces an elevation of fibrinogen in rats by an extrathyroideal mechanism. 相似文献
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