The challenge of new drug discovery for tuberculosis

Tuberculosis (TB) is more prevalent in the world today than at any other time in human history. Mycobacterium tuberculosis, the pathogen responsible for TB, uses diverse strategies to survive in a variety of host lesions and to evade immune surveillance. A key question is how robust are our approaches to discovering new TB drugs, and what measures could be taken to reduce the long and protracted clinical development of new drugs. The emergence of multi-drug-resistant strains of M. tuberculosis makes the discovery of new molecular scaffolds a priority, and the current situation even necessitates the re-engineering and repositioning of some old drug families to achieve effective control. Whatever the strategy used, success will depend largely on our proper understanding of the complex interactions between the pathogen and its human host. In this review, we discuss innovations in TB drug discovery and evolving strategies to bring newer agents more quickly to patients.     

Variable camber airfoil: New concept, new challenge

Aircraft morphing,especially in the case of the variable camber airfoil,has potential from the viewpoints of both fundamental aerodynamics and flight application.In the field of aerodynamics,the use of a variable camber airfoil can improve aircraft flight performance and allow effi-     

OSI协议软件的实现及迁移技术

本文从系统的设计和实现两方面讨论了ＯＳＩ协议软件的实现策略，并介绍了基于协议和基于服务等两种从ＴＣＰ／ＩＰ协议套实现向ＯＳＩ协议套实现的迁移方法以及一些实例。