常压微波合成L-2-邻羟苯基-噻唑烷-4-甲酸

以乙醇和水为介质,在常压微波反应条件下用L-半胱氨酸与邻-羟基苯甲醛合成L-2-邻羟苯基-噻唑烷-4-甲酸.讨论了微波功率和反应时间对产率的影响.实验表明微波技术可用于光学活性物质的合成,并显示出微波合成的简便、安全、快速、产率高的特点.     

N'-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮的合成及生物活性

以5-溴水杨酸为原料,将其与水合肼反应生成了5-溴水杨酰肼,再将硫氰酸钾与5-溴水杨酰肼反应合成了5-溴水杨酰基氨基硫脲,后者与溴代乙酸乙酯反应生成了终产物N'-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮.对化合物进行了熔点、IR、元素分析、1H NMR、13C NMR表征,并测试了其对生物体的抗炎活性和抗菌活性.结果表明:N'-(2-羟基-5-溴苯甲酰胺基)-2-亚胺基-4-噻唑烷酮具有较好的抗炎、抗菌活性.     

HPLC法测定蒙药复方述达格-4中1-苯基-7-(3-甲氧基-4-羟基)苯基-5-醇-3-庚酮的含量

建立测定蒙药复方述达格-4药材中1-苯基-7-(3-甲氧基-4-羟基)苯基-5-醇-3-庚酮含量的方法.色谱柱为InertsilODS-3(4.6mm×250mm,5μm),以乙腈(B)-0.5%磷酸水溶液(A)为流动相,梯度洗脱(0~20min,0%B→45%B;20~25min,45%B→55%B;25~40min,55%B→100%B),流速1.0ml·min-1,检测波长为210nm,柱温30℃,进样量20μL.结果表明蒙药复方述达格-4药材中1-苯基-7-(3-甲氧基-4-羟基)苯基-5-醇-3-庚酮在0.102-1.02μg(r=0.99999)质量范围内与色谱峰面积呈良好的线性关系,精密度、稳定性、重复性试验的RSD≤2%,平均加样回收率(n=6)为99.63%(RSD=1.77%).本法简便、快速、准确,可为蒙药复方述达格-4的质量控制提供依据.     

纤维素-三（苯基氨基甲酸酯）手性固定相的制备及多种手性化合物的拆分

以微晶纤维素和苯基异氰酸酯为原料,合成了纤维素-三(苯基氨基甲酸酯),并以经3-氨丙基-三乙氧基硅烷修饰的硅胶为裁体,制备了涂敷型纤维素-三(苯基氨基甲酸酯)液相色谱固定相,对该固定相进行了表征,并在正相条件下对14种对映异构体进行了拆分,其中8种得到了分离,该柱表现出良好的手性分离性能.     

N'-(2-羟基-4-甲基-苯甲酰胺基)-2-亚胺基-4-噻唑烷酮的合成及生物活性

为探讨4-噻唑烷酮衍生物的生物活性,用4-甲基水杨酸甲酯和水合肼作为原料反应得到4-甲基水杨酰肼,再将其与硫氰酸钾合成得4-甲基水杨酰氨基硫脲,最后与溴代乙酸乙酯反应合成终产物N'-(2-羟基-4-甲基苯甲酰胺基)-2-亚胺基-4-噻唑烷酮.对其进行了~(13)C NMR、IR、~1H NMR和元素分析表征,并对该化合物进行了体内抗炎活性和体外抗菌活性的测试.结果表明:该化合物具有较好的抗炎和抗菌活性.     

噻唑烷-4-酮衍生物抗HCMV和VZV的活性

利用病毒噬斑抑制法,探讨了2,3-二芳基-1,3-噻唑烷-4-酮(化合物1和2)、含糖基的1,3-噻唑烷-4-酮(化合物3和4)抗人巨细胞疱疹病毒(HCMV)和水痘带状疱疹病毒(VZV)活性.结果表明:2,3-二芳基-1,3-噻唑烷-4-酮是一类新型高效的抗HCMV化合物,而含糖基的1,3-噻唑烷-4-酮可能是一类比较...     

α-苯乙醇的高效液相色谱手性拆分研究

本文用实验室自制的纤维素三(3,5-二甲基苯基氨基)甲酸酯和纤维素三(4-甲基苯)甲酸酯涂敷于硅胶上,分别制成OD柱和OJ柱.在OD柱和OJ柱上对外消旋体α-苯乙醇进行了拆分,分别考察了流动相中异丙醇的含量对α-苯乙醇手性拆分的影响,还分别考察了流动相中1%(V/V)的正丙醇、异丙醇、正丁醇、叔丁醇对α-苯乙醇拆分的影响.我们选择了最佳的拆分方法,并将此方法应用于苯乙酮不对称催化还原产物的光学纯度的鉴定中,将苯乙酮在NaBH4为还原剂下,在自制的手性聚合物金属络合物PMA-QN-PdCl2催化剂作用下被还原,取得了满意的结果.     

1， 4-双［2-(3， 4， 5-三甲氧基苯基)乙烯基］苯异构体的分离和色谱测定

研究了 1,4 -双 [2 - ( 3,4 ,5-三甲氧基苯基 )乙烯基 ]苯合成产物中的三种异构体的柱色谱分离方法 ,用硅胶为固定相 ,乙酸乙酯和环己烷混合液为流动相 ,分离产物所达纯度分别为顺 -顺式 97% ,顺 -反式 96% ,反 -反式 99% .另外 ,还进行了HPV异构体的HTGC或HPLC的定性和定量测定法研究     

新型苄氧羰基苯丙氨酸环糊精衍生物键合硅胶手性固定相的合成与评价

在β-环糊精6位羟基上导人苄氧羰基(CBZ)保护苯丙氨酸,并将该衍生物与硅胶键合制备了高效液相色谱手性固定相.采用莫氏颜色试验、红外光谱、X射线光电子能谱等方法表征了环糊精衍生物和键合固定相.以苯和萘为测试物评价了键合固定相色谱柱的效能.使用该色谱柱实现了硝基苯酚和氨基苯酚位置异构体的分离.盐酸克伦特罗和5,6-氧-异丙叉基-3-硫-己酸-1,4-内酯的手性异构体也获得一定程度的拆分.     

痕量锰的在线萃取色谱法富集AAS法测定

以2-巯基苯骈噻唑和8-羟基喹啉为复合萃取剂,活性硅胶为载体制成色谱柱,研究了该柱对锰离子的吸附条件和洗脱条件,建立了痕量锰以60次/h分析速度的流动注射在线萃取色谱法预浓集原子吸收光谱测定的方法,用于水样分析获得满意效果.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

An affordable accurate evaluation of the binding conformations predicted by molecular docking studies in bio-system

Franck-Condon factors bridge the gap between theoretical modeling and experimental observations for molecular electronic spectroscopy and electron transfer.Under the displaced harmonic oscillator approximation,multidimensional Franck-Condon factors are decomposed into a product of many one-dimensional(1D)Franck-Condon(FC)factors,and each 1D-FC factor is associated with one Huang-Rhys factor that determines the leading contribution of     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with     

Journal of Donghua University ( English Edition) Contents of Volume 31

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