那特真联合结膜遮盖术治疗真菌性角膜炎

目的：探讨那特真联合结膜遮盖术治疗真菌性角膜炎的疗效.方法：全部病例均先采用那特真滴眼液点眼,对重症角膜溃疡的患者联合结膜瓣遮盖术治疗.结果：21例患者角膜溃疡完全愈合.结论：那特真对真菌性角膜炎有较好的疗效,重症角膜溃疡的患者尽早联合结膜瓣遮盖术,可明显提高治愈率.     

氟康唑、伊曲康唑治疗孢子丝菌病的临床疗效及体外抗真菌药敏试验研究

目的观察氟康唑、伊曲康唑对孢子丝菌病的临床疗效,检测孢子丝菌对氟康唑、伊曲康唑的体外敏感性,探讨孢子丝菌病治疗的新方法.方法对120例孢子丝菌病患者分别给予氟康唑片和伊曲康唑胶囊口服治疗,30例患者给予碘化钾溶液口服治疗,并采用E-test法检测其中10株孢子丝菌对氟康唑和伊曲康唑的最小抑菌浓度(MIC).结果氟康唑对孢子丝菌病的总有效率95.00%,伊曲康唑对孢子丝菌病的总有效率96.66%,碘化钾溶液对孢子丝菌病的总有效率86.67%.采用Etest法检测10株孢子丝菌对氟康唑和伊曲康唑的MIC值,范围为2～256mg/L,0.012～8.0mg/L.结论申克氏孢子丝菌对伊曲康唑具有良好的敏感性,对氟康唑的体外敏感性较低,但氟康唑和伊曲康唑对孢子丝菌病均有较好的疗,副作用小.     

两性霉素B联合氟康唑滴眼液治疗真菌性角膜炎的临床疗效

研究两性霉素B联合氟康唑滴眼液治疗真菌性角膜炎的临床疗效.将98例真菌性角膜炎患者分为A、B、C组,A组39例,采用两性霉素B联合氟康唑滴眼液治疗;B组30例,采用氟康唑滴眼液治疗;C组29例,采用两性霉素B溶液治疗,治疗1月后比较3组临床疗效.治疗结束后,3组患者的各项症状与体征均得到显著改善,总有效率分别为92.3％,70.0％及65.5％,3组治疗结果相比,氟康唑滴眼液联合两性霉素B组治疗效果较单纯氟康唑组及单纯两性霉素B组明显,差异有显著性(P＜0.05).两性霉素B联合氟康唑滴眼液治疗真菌性角膜炎具有较好的临床疗效和安全性,值得临床推广应用.     

182例真菌感染性角膜炎 临床特征及致病菌分布特征分析

目的分析真菌感染性角膜炎的病因、人群及致病菌的分布特征,为真菌性角膜炎的临床诊治提供参考.方法收集182例182眼真菌感染性角膜炎患者的临床资料,回顾性分析其病因、人群特征及临床危险因素、治疗时间.结果 182例真菌感染性角膜炎患者中,经5%那他霉素滴眼液治愈119例119眼患者,另有27例27眼明显好转,其余36例36眼患者经联合伏立康唑治疗后,31例31眼明显好转,5例5眼继续恶化,最终3例3眼行穿透性角膜移植,2例2眼行眼内容物剜除术.结论真菌感染性角膜炎患者致病菌多为镰刀菌属,5%那他霉素联合伏立康唑可有效治疗真菌性角膜炎,降低患者手术率.     

伊曲康唑对K562细胞增殖及HUVEC细胞血管形成的影响

老药新用是许多药物研究者关注的焦点.伊曲康唑作为临床应用近30年的抗真菌药物,其安全性毋庸置疑.近年来研究者们陆续发现伊曲康唑还具有抗肿瘤的作用,然而对于伊曲康唑抑制人慢性髓原白血病的增殖作用却鲜有报道.为了研究伊曲康唑抑制白血病K562细胞增殖的作用及其抑制血管形成的作用,采用MTT法、Annexin VFITC/PI双染法和基质胶血管形成实验等方法研究伊曲康唑对白血病K562细胞存活率、增殖曲线、细胞形态学变化、细胞凋亡、细胞周期变化和管腔形成的影响,揭示了伊曲康唑能够抑制K562细胞增殖并能抑制血管形成,以此为进一步研究与改造伊曲康唑的抗肿瘤作用提供基础数据.     

深部真菌感染治疗药物药效比较研究

深部真菌感染的各种疾病,如念珠菌病、霉菌病、隐球菌病等的治疗,由制霉菌素、灰色霉素、两性霉素B,发展到用咪唑类药物,如酮康唑、伊曲康唑、氟康唑、沃利康唑等高效、低毒、选择性好的新型抗真菌药。这些新型抗真菌解决了真菌的耐药问题,制止了盲目的用药。特别是采取联合用药的方法,使深部真菌病的治疗进入一个新时代。     

伊曲康唑胶囊联合克霉唑阴道片治疗霉菌性阴道炎临床研究

研究伊曲康唑胶囊联合克霉唑阴道片治疗霉菌性阴道炎的临床效果。选取甘肃省临潭县中医院收治的霉菌性阴道炎患者98例,依据随机数字表法将患者分为两组(观察组和对照组),每组各49例。对照组予以克霉唑阴道片治疗,观察组在对照组的基础上应用伊曲康唑胶囊治疗。观察比较两组患者的临床治疗效果、不良反应以及复发率发生情况。观察组治疗后有效率89.80%,明显高于照组67.35%(P0.05);观察组患者治疗后不良反应发生率与对照组对比,无明显差异(P0.05);观察组复发率比对照组低(P0.05)。联合应用伊曲康唑胶囊与克霉唑阴道片治疗霉菌性阴道炎起效快、疗效显著,复发率低,且安全性有可靠保证。     

伊曲康唑胶囊与联苯苄唑乳膏联合治疗念珠菌性阴道炎

１资料与方法 （１）资料：伊曲康哩胶囊为比利时西安杨森公司生产，商品名“斯皮仁诺”， １００ ｍｇ／粒；联苯苄唑乳膏为北京四环制药厂生产，商品名“孚琪”（ｗ＝ ０．０１）；随机抽取 １９９８年 １～ ６月本门诊部可随访念珠菌性阴道炎患者２００例，年龄１８～４９岁，平均２９岁，就诊时以生理盐水涂片法或革兰氏染色法及真菌培养均确诊为念珠菌感染。 （２）方法：随机将病人分为单服伊曲康唑组和伊曲康唑＋联苯苄唑合并治疗组各１００例。伊曲康唑为每日１次服用２００ｍｇ，连服３ｄ；联苯苄唑每晚阴道内给药１～２ｇ，连用２…     

伊曲康唑治疗甲真菌病52例疗效及后效应观察

目的:详细观察伊曲康唑对甲真菌病的效果及后效应。方法:用伊曲康哇间歇冲击疗法治疗甲真菌病52例。结果:治疗结束时指甲真菌病临床有效率为45.5％,趾甲真菌病临床有效率为41.5％,用药第40周指甲真菌病有效率为90.9％,趾甲真菌病有效率为90.25％,治疗结束时疗效与用药第40周疗效相比,其临床有效率在统计学上有非常显著差异。结论:伊曲康唑治疗甲真菌病有良好的“药物后效应”。     

氟康唑治疗真菌性角膜溃疡20例临床分析

目的 探讨氟康唑注射液治疗真菌性角菌溃疡的疗效.方法 用氟康唑注射液100mL静脉点滴及自配2%氟康唑眼药水滴眼治疗真菌性角膜溃疡20例.结果 20例中17例真菌性角膜溃疡愈合,前房积脓消失,角膜溃疡面积缩小.结论 氟康唑注射液治疗真菌性角膜溃疡疗效较好,不良反应少.     

Markedness and its Interpretation in Language Use

Language markedness is a common phenomenon in languages, and is reflected from hearing, vision and sense, i.e. the variation in the three aspects such as phonology, morphology and semantics. This paper focuses on the interpretation of markedness in language use following the three perspectives, i.e. pragmatic interpretation, psychological interpretation and cognitive interpretation, with an aim to define the function of markedness.     

Features of Women's language

Language is a means of verbal communication. People use language to communicate with each other. In the society, no two speakers are exactly alike in the way of speaking. Some differences are due to age, gender, statue and personality. Above all, gender is one of the obvious reasons. The writer of this paper tries to describe the features of women＇s language from these perspectives： pronunciation, intonation, diction, subjects, grammar and discourse. From the discussion of the features of women＇s language, more attention should be paid to language use in social context. What＇s more, the linguistic phenomena in a speaking community can be understood more thoroughly.     

低渗透非均质砂岩油藏启动压力梯度研究

理论推导与室内实验相结合,建立了低渗透非均质砂岩油藏启动压力梯度确定方法。首先借助油藏流场与电场相似的原理,推导了非均质砂岩油藏启动压力梯度计算公式。其次基于稳定流实验方法,建立了非均质砂岩油藏启动压力梯度测试方法。结果表明:低渗透非均质砂岩油藏的启动压力梯度确定遵循两个等效原则。平面非均质油藏的启动压力梯度等于各级渗透率段的启动压力梯度关于长度的加权平均;纵向非均质油藏的启动压力梯度等于各渗透率层的启动压力梯度关于渗透率与渗流面积乘积的加权平均。研究成果可用于有效指导低渗透非均质砂岩油藏的合理井距确定,促进该类油藏的高效开发。     

On Tragic Consciousness In The Works By Ernest Hemingway

As an American modern novelist who were famous in the literary world, Hemingway was not a person who always followed the trend but a sharp observer. At the same time, he was a tragedy maestro, he paid great attention on existence, fate and end-result. The dramatis personae's tragedy of his works was an extreme limit by all means tragedy on the meaning of fearless challenge that failed. The beauty of tragedy was not produced on the destruction of life, but now this kind of value was in the impact activity. They performed for the reader about the tragedy on challenging for the limit and the death.     

Achieving Unusual States of Matter Under High Pressure

正The periodicity of the elements and the non-reactivity of the inner-shell electrons are two related principles of chemistry,rooted in the atomic shell structure.Within compounds,Group I elements,for example,invariably assume the+1 oxidation state,and their chemical properties differ completely from those of the p-block elements.These general rules govern our understanding of chemical structures and reactions.Using first principles calcula-     

Exchange-Correlation and Electronic Excitation Energies from Pairing Matrix Fluctuations

We have developed an adiabatic connection to formulate the ground-state exchange-correlation energy in terms of pairing matrix linear fluctuations.This formulation of the exchange-correlation energy opens a new channel for density functional approximations based on the many-body perturbation theory.We illustrate the potential of such approaches with an approximation based on the particle-particle Random Phase Approximation(pp-RPA).This re-     

Density Functional Theory for the Response of Periodic Systems to Electric Fields Based on the Vector Potential Approach

正The electronic and nuclear(structural/vibrational)response of 1D-3D nanoscale systems to electric fields gives rise to a host of optical,mechanical,spectral,etc.properties that are of high theoretical and applied interest.Due to the computational difficulty of treating such large systems it is convenient to model them as infinite and periodic(at least,in first approximation).The fundamental theoretical/computational problem in doing so is that     

On the Thermodynamic Limit for Responses to Static Electromagnetic Fields

For molecular systems,the quantum-mechanical treatment of their responses to static electromagnetic fields usually employs a scalar-potential treatment of the electric field and a vector-potential treatment of the magnetic field.Although the potential for each field separately is associated with the choice of an(unphysical)origin,the precise choice of the origin for the electrostatic field has little consequences for the results.This is different for the     

An affordable accurate evaluation of the binding conformations predicted by molecular docking studies in bio-system

Franck-Condon factors bridge the gap between theoretical modeling and experimental observations for molecular electronic spectroscopy and electron transfer.Under the displaced harmonic oscillator approximation,multidimensional Franck-Condon factors are decomposed into a product of many one-dimensional(1D)Franck-Condon(FC)factors,and each 1D-FC factor is associated with one Huang-Rhys factor that determines the leading contribution of     

Call for Papers

<正>"The Journal of Shanghai Normal University:Mathematics"is published by Shanghai Normal University as regular issues of The Journal of Shanghai Normal University each year from 2014 in English.The editors-in-chief of the issues are professors Yuhao Cong and Maoan Han.The Journal of Shanghai Normal University was started in 1958 with