What's new in the field of cancer vaccines?

The observation that in some cases tumors undergo spontaneous regression concomitantly with autoimmune manifestations has been interpreted as an indication of the involvement of the immune system in tumor rejection. This raised the conceptual possibility that the immune system could be used against the tumor. However, since tumor cells are poorly immunogenic by themselves, early attempts to develop immune-based approaches for cancer therapy saw the use of tumor cells transduced with genes coding for cytokines or costimulatory molecules to enhance in vivo immunity. The identification of cytotoxic T lymphocyte (CTL)-defined tumor associated antigens has allowed the development of new strategies for cancer immunotherapy. Novel adjuvants have been identified, and different modes of antigen delivery were devised which aim at inducing efficient CTL responses in patients. This review will discuss some of what is currently considered as relevant aspects of antitumor immunization.Received 19 July 2002; received after revision 11 December 2002; accepted 13 December 2002     

The ontology of quantum field theory: Structural realism vindicated?

In this paper I elicit a prediction from structural realism and compare it, not to a historical case, but to a contemporary scientific theory. If structural realism is correct, then we should expect physics to develop theories that fail to provide an ontology of the sort sought by traditional realists. If structure alone is responsible for instrumental success, we should expect surplus ontology to be eliminated. Quantum field theory (QFT) provides the framework for some of the best confirmed theories in science, but debates over its ontology are vexed. Rather than taking a stand on these matters, the structural realist can embrace QFT as an example of just the kind of theory SR should lead us to expect. Yet, it is not clear that QFT meets the structuralist's positive expectation by providing a structure for the world. In particular, the problem of unitarily inequivalent representations threatens to undermine the possibility of QFT providing a unique structure for the world. In response to this problem, I suggest that the structuralist should endorse pluralism about structure.     

One hundred years of Weyl’s (unfinished) unified field theory

In 1918, H. Weyl proposed a unified theory of gravity and electromagnetism based on a generalization of Riemannian geometry. In spite of its elegance and beauty, a serious objection was raised by Einstein, who argued that Weyl’s theory was not suitable as a physical theory . According to Einstein, the theory led to the prediction of a “second clock effect”, which has not been observed by experiments as yet. We briefly revisit this point and argue that a preliminary discussion on the very notion of proper time is needed in order to consider Einstein’s critical point of view. We also point out that Weyl theory is basically incomplete in its original version and its completion may lead to a rich and interesting new approach to gravity.     

Naturalness,Wilsonian renormalization,and “fundamental parameters” in quantum field theory

The Higgs naturalness principle served as the basis for the so far failed prediction that signatures of physics beyond the Standard Model (SM) would be discovered at the LHC. One influential formulation of the principle, which prohibits fine tuning of bare Standard Model (SM) parameters, rests on the assumption that a particular set of values for these parameters constitute the “fundamental parameters” of the theory, and serve to mathematically define the theory. On the other hand, an old argument by Wetterich suggests that fine tuning of bare parameters merely reflects an arbitrary, inconvenient choice of expansion parameters and that the choice of parameters in an EFT is therefore arbitrary. We argue that these two interpretations of Higgs fine tuning reflect distinct ways of formulating and interpreting effective field theories (EFTs) within the Wilsonian framework: the first takes an EFT to be defined by a single set of physical, fundamental bare parameters, while the second takes a Wilsonian EFT to be defined instead by a whole Wilsonian renormalization group (RG) trajectory, associated with a one-parameter class of physically equivalent parametrizations. From this latter perspective, no single parametrization constitutes the physically correct, fundamental parametrization of the theory, and the delicate cancellation between bare Higgs mass and quantum corrections appears as an eliminable artifact of the arbitrary, unphysical reference scale with respect to which the physical amplitudes of the theory are parametrized. While the notion of fundamental parameters is well motivated in the context of condensed matter field theory, we explain why it may be superfluous in the context of high energy physics.     

State of the field: Are the results of science contingent or inevitable?

This paper presents a survey of the literature on the problem of contingency in science. The survey is structured around three challenges faced by current attempts at understanding the conflict between “contingentist” and “inevitabilist” interpretations of scientific knowledge and practice. First, the challenge of definition: it proves hard to define the positions that are at stake in a way that is both conceptually rigorous and does justice to the plethora of views on the issue. Second, the challenge of distinction: some features of the debate suggest that the contingency issue may not be sufficiently distinct from other philosophical debates to constitute a genuine, independent philosophical problem. And third, the challenge of decidability: it remains unclear whether and how the conflict could be settled on the basis of empirical evidence from the actual history of science. The paper argues that in order to make progress in the present debate, we need to distinguish more systematically between different expressions that claims about contingency and inevitability in science can take. To this end, it introduces a taxonomy of different contingency and inevitability claims. The taxonomy has the structure of an ordered quadruple. Each contingency and each inevitability claim contains an answer to the following four questions: (how) are alternatives to current science possible, what types of alternatives are we talking about, how should the alternatives be assessed, and how different are they from actual science?     

Allozyme polymorphism and linkage disequilibrium ofAdh and α-Gpdh loci in wine cellar and field populations ofDrosophila melanogaster

Summary Over three years, theAdh and -Gpdh loci have been studied in two cellar populations ofDrosophila melanogaster and in two field populations which were each near to one of the cellars. Analyses of gene frequencies indicate that the divergence among subpopulations is greater in theAdh locus than in the -Gpdh locus. Selection for or againstAdh ^S allele acting on theIn(2L)t inversion influences of the -Gpdh alleles. This phenomenon may contribute to explain the maintenance of theAdh and -Gpdh polymorphism and of theIn(2L)t inversion.     

Application of the ‘low-temperature plasma ashing method for biological tissues’ to studies in the field of virology

Summary It was found that the behavior of a virus in host plant is reflected in the pattern of crystalline inorganic components of the host plant by the technique of the low-temperature plasma ashing method for biological tissues.     

What's nu? A re-examination of Maxwell's ‘ratio-of-units’ argument,from the mechanical theory of the electromagnetic field to ‘On the elementary relations between electrical measurements’

This re-examination of the earliest version of Maxwell's most important argument for the electromagnetic theory of light—the equality between the speed of wave propagation in the electromagnetic ether and the ratio of electrostatic to electromagnetic measures of electrical quantity—establishes unforeseen connections between Maxwell's theoretical electrical metrology and his mechanical theory of the electromagnetic field. Electrical metrology was not neutral with respect to field-theoretic versus action-at-a-distance conceptions of electro-magnetic interaction. Mutual accommodation between these conceptions was reached by Maxwell on the British Association for the Advancement of Science (BAAS) Committee on Electrical Standards by exploiting the measurement of the medium parameters—electric inductive capacity and magnetic permeability—on an arbitrary scale. While he always worked within this constraint in developing the ‘ratio-of-units’ argument mathematically, I maintain that Maxwell came to conceive of the ratio ‘as a velocity’ by treating the medium parameters as physical quantities that could be measured absolutely, which was only possible via the correspondences between electrical and mechanical quantities established in the mechanical theory. I thereby correct two closely-related misconceptions of the ratio-of-units argument—the counterintuitive but widespread notion that the ratio is naturally a speed, and the supposition that Maxwell either inferred or proved this from its dimensional formula.